{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:06:38Z","timestamp":1790384798636,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:00:00Z","timestamp":1749859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF21SA0069370"],"award-info":[{"award-number":["NNF21SA0069370"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Up to 70% of sudden cardiac death (SCD) cases in younger individuals are potentially caused by an inherited heart disease. However, long-term diagnostic yield and risk of cardiac events in SCD relatives remain unclear. This study aimed to determine the 10-year diagnostic yield of inherited heart diseases and frequency of cardiac events in SCD relatives.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This retrospective study included SCD probands and their relatives referred to the Unit for Inherited Heart Diseases at Rigshospitalet, Denmark, from 2005 to 2018. Relatives underwent guideline-recommended screening and follow-up. Diagnoses and cardiac events, such as new-onset reduced left ventricular ejection fraction \u226445%, sustained ventricular tachycardia, appropriate implantable cardioverter-defibrillator therapy, cardiac death, and (aborted) SCD, were registered. A total of 686 relatives (47% males, median baseline age 35 years) to 299 probands (75% males, median death age 41 years) were followed for a median of 10.6 years. At 10-year follow-up, 12% of relatives (n = 82) were diagnosed with an inherited heart disease, with 93% (n = 76) diagnosed within 5 years. Cardiac events occurred in 18 (3%) and 24 (4%) relatives after 5- and 10-year follow-up, respectively. Five (0.7%) relatives of probands with no established diagnosis, who had no diagnosis nor cardiac event within 5 years of follow-up, were diagnosed between &amp;gt;5 and 10 years of follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Long-term follow-up identified an inherited heart disease in 12% of SCD relatives, primarily diagnosed within 5 years. Cardiac events were rare (4%). These findings suggest that follow-up may be considered limited to 5 years for specific adult SCD relatives.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaf119","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T08:53:04Z","timestamp":1749891184000},"source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic yield in families to sudden cardiac death victims: a 10-year follow-up study"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5428-7360","authenticated-orcid":false,"given":"Christine Louise","family":"Gr\u00f8nholdt","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]},{"name":"EMS Research Center, Emergency Medical Services Capital Region of Denmark\u2014University of Copenhagen , Telegrafvej 5A, 2750 Ballerup ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4877-5484","authenticated-orcid":false,"given":"Benjamin Lautrup","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2284-7857","authenticated-orcid":false,"given":"Fredrik","family":"Folke","sequence":"additional","affiliation":[{"name":"EMS Research Center, Emergency Medical Services Capital Region of Denmark\u2014University of Copenhagen , Telegrafvej 5A, 2750 Ballerup ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Herlev-Gentofte, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9394-0752","authenticated-orcid":false,"given":"Trine Kiilerich","family":"Lauridsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev-Gentofte, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8665-3309","authenticated-orcid":false,"given":"Anna","family":"Axelsson Raja","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-4712","authenticated-orcid":false,"given":"Bo Gregers","family":"Winkel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-7049","authenticated-orcid":false,"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3895-9316","authenticated-orcid":false,"given":"Jacob","family":"Tfelt-Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]},{"name":"Department of Forensic Medicine, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6855-1496","authenticated-orcid":false,"given":"Alex H\u00f8rby","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Herlev-Gentofte, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8074-7731","authenticated-orcid":false,"given":"Carolina","family":"Malta Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]},{"name":"EMS Research Center, Emergency Medical Services Capital Region of Denmark\u2014University of Copenhagen , Telegrafvej 5A, 2750 Ballerup ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Herlev-Gentofte, Copenhagen University Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,14]]},"reference":[{"key":"2025071605462304300_euaf119-B1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.hrthm.2022.08.036","article-title":"Causes of sudden cardiac death according to age and sex in persons aged 1\u201349 years","volume":"20","author":"Lynge","year":"2023","journal-title":"Heart 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