{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T19:29:18Z","timestamp":1771961358142,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union's Horizon-2020 research and innovation programme","award":["945119"],"award-info":[{"award-number":["945119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Stereotactic arrhythmia radioablation (STAR) has emerged as bail-out treatment for ventricular tachycardia (VT). Accurate, reproducible, and easy-to-use data transfer from electroanatomical mapping (EAM) systems to radiotherapy planning CT is desirable. We aim to evaluate interobserver variability, ease of use, and learning curve for EAM based target volume (CardTV-EPinv) creation and transfer using available software packages.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>In patients considered for STAR, CardTV-EPinv were created using ADAS and Slicer3D for workflow comparison. Four CardTV-EPinv (clinically targeted volume and three mock targets) were created by an experienced operator and a 2nd-year medical student, based on endocardial EAM tags indicating VT substrate location. CardTV-EPinv sizes, Hausdorff distances (HDs), and workflow duration were measured to assess interobserver variability and learning curve. Agreement between CardTV-EPinv was high using ADAS and Slicer3D workflows (HD 3.64\u2005mm [2.7\u20134.5]). ADAS workflow was faster and more robust (ADAS 26\u2005min [24\u201329] vs. Slicer3D 65\u2005min [61\u201370], P &amp;lt; 0.001; system crashes: ADAS 0 vs. Slicer3D 7). In 20 patients (80% non-ischaemic cardiomyopathy, LVEF 35 \u00b1 14%), 80 CardTV-EPinv were created using ADAS. CardTV-EPinv size was similar for both observers (11.8\u2005mL [10.1\u201313.7] vs. 10.7\u2005mL [9.6\u201311.8], P = 0.17), with high interobserver agreement (HD 1.68\u2005mm [1.45\u20131.96]; 95th percentile HD &amp;lt; 4.8\u2005mm [3.5\u20135.7]). Linear regression showed a steep learning curve for the student (P = 0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>CardTV-EPinv creation showed excellent interobserver agreement and was faster and more robust using ADAS than 3D slicer. The steep learning curve appears clinically relevant given the limited use of STAR even in high-volume VT ablation centres.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaf122","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T05:03:21Z","timestamp":1750050201000},"source":"Crossref","is-referenced-by-count":2,"title":["Excellent interobserver agreement and steep learning curve for target volume delineation for stereotactic arrhythmia radioablation using a commercial software"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-1535","authenticated-orcid":false,"given":"Robert","family":"Rademaker","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , P.O. Box 9600, Leiden 2300 RC ,","place":["The Netherlands"]},{"name":"Willem Einthoven Center of Arrhythmia Research and Management, Leiden, The Netherlands , Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Cirkel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , P.O. Box 9600, Leiden 2300 RC ,","place":["The Netherlands"]},{"name":"Willem Einthoven Center of Arrhythmia Research and Management, Leiden, The Netherlands , Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3961-8647","authenticated-orcid":false,"given":"Sharif","family":"Omara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , P.O. Box 9600, Leiden 2300 RC ,","place":["The Netherlands"]},{"name":"Willem Einthoven Center of Arrhythmia Research and Management, Leiden, The Netherlands , Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1354-3723","authenticated-orcid":false,"given":"Frank J W M","family":"Dankers","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1379-0086","authenticated-orcid":false,"given":"Marek","family":"Sramko","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute for Clinical and Experimental Medicine , Prague ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-7248","authenticated-orcid":false,"given":"J","family":"Solana Munoz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lausanne University Hospital , Lausanne ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4149-4504","authenticated-orcid":false,"given":"Yesim S","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maastricht University Medical Center+ (MUMC+), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Maastricht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-0132","authenticated-orcid":false,"given":"Rachel M A","family":"Ter Bekke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maastricht University Medical Center+ (MUMC+), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University , Maastricht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7621-1662","authenticated-orcid":false,"given":"Luis","family":"Schiappacasse","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Lausanne University Hospital , Lausanne ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8786-7976","authenticated-orcid":false,"given":"Cheryl","family":"Teres","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lausanne University Hospital , Lausanne ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolien","family":"Verhoeven","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (Maastro), GROW-Research Institute for Oncology and Reproduction, Maastricht University Medical Center+ , Maastricht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-9285","authenticated-orcid":false,"given":"Etienne","family":"Pruvot","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lausanne University Hospital , Lausanne ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6950-3376","authenticated-orcid":false,"given":"Coen R N","family":"Rasch","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Leiden University Medical Center , Leiden ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6645-082X","authenticated-orcid":false,"given":"Katja","family":"Zeppenfeld","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center , P.O. 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