{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:14:44Z","timestamp":1756901684534,"version":"3.44.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016242","name":"Boston Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016242","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007497","name":"Biosense Webster","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Horizon IMPACT","award":["#101115536"],"award-info":[{"award-number":["#101115536"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The task force criteria (TFC) for arrhythmogenic right ventricular cardiomyopathy (ARVC) are highly sensitive but lack specificity. Atypical RV involvement (aRVi) may indicate different underlying aetiologies and prognosis, requiring specific therapeutic interventions. We aimed to evaluate the role of the baseline 12-lead ECG for initial suspicion of aRVi.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From the Netherlands Heart Institute Arrhythmogenic Cardiomyopathy (NHI-ACM) registry, patients were selected who (i) fulfilled TFC for definite ARVC, (ii) presented with sustained ventricular tachycardia (VT), and (iii) underwent genetic testing. The first available ECG after VT was evaluated. PR prolongation \u2265220\u2005ms and\/or a surface area of the maximum R\u2032-wave in V1\u2013V3 of \u22651.65\u2005mm2 was defined as an aRVi-ECG. Patients with an ARVC-related pathogenic\/likely pathogenic variant (P\/LP+) were classified as \u2018ARVC\u2019. Data of P\/LP\u2212 were reviewed by an expert panel and classified as either \u2018ARVC\u2019 or \u2018different aetiology\u2019 based on consensus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 159 patients were included (122 P\/LP+ and 37 P\/LP\u2212 patients). Nineteen patients had an aRVi-ECG [11 (9%) P\/LP+ vs. 8 (22%) P\/LP\u2212, P = 0.038]. Of the P\/LP\u2212 patients, 17 (46%) were classified as \u2018different aetiology\u2019 (e.g. myocarditis, ischaemia, sarcoidosis), including all 8 patients with an aRVi-ECG. Among the P\/LP+ patients with an aRVi-ECG, 46% carried the p.Arg14del phospholamban pathogenic variant, and 64% died compared to 15 and 19% of P\/LP+ patients without an aRVi-ECG, respectively (both P &amp;lt; 0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In P\/LP\u2212 patients presenting with VT and fulfilling TFC, an aRVi-ECG should raise suspicion for a different underlying aetiology. In P\/LP+ patients, an aRVi-ECG may identify those with poor outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaf136","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T10:52:53Z","timestamp":1755687173000},"source":"Crossref","is-referenced-by-count":0,"title":["Different underlying aetiologies in patients presenting with ventricular tachycardia fulfilling task force criteria for arrhythmogenic right ventricular cardiomyopathy: initial suspicion based on the 12-lead electrocardiogram"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8090-2447","authenticated-orcid":false,"given":"Jarieke C","family":"Hoogendoorn","sequence":"first","affiliation":[{"name":"Department of Cardiology, Willem Einthoven Center for Cardiac Arrhythmia Research and Management (WECAM), Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden ,","place":["The 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Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-5354","authenticated-orcid":false,"given":"Dennis","family":"Dooijes","sequence":"additional","affiliation":[{"name":"Department of Genetics, University Medical Center Utrecht, University of Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-4790","authenticated-orcid":false,"given":"Anneline S J M","family":"Te Riele","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht , Utrecht ,","place":["The Netherlands"]},{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart 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