{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:08:01Z","timestamp":1790932081405,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070412"],"award-info":[{"award-number":["82070412"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenzhen Science and Technology Program","award":["CJGJZD20240729143100001"],"award-info":[{"award-number":["CJGJZD20240729143100001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Nanosecond pulsed field ablation (nsPFA) has emerged as an alternative in atrial fibrillation (AF) ablation. It leverages the alleviated muscle contractions (MCs) associated with nanosecond pulses, which may reduce complications and anaesthetic requirements compared with conventional microsecond PFA (\u03bcsPFA). To pre-clinically compare the safety, efficacy, and MC effects of nsPFA and \u03bcsPFA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Typical parameters were tested for pulmonary vein isolation (PVI) in swine using a novel commercial PFA system with either nsPFA or \u03bcsPFA protocols. Procedural outcomes and histological analysis were evaluated at 3-, 30-, and 90-day follow-ups. Electrical stimulation experiments were conducted using various pulse voltages and widths (ranging from nanoseconds to microseconds) to evaluate contractions in swine. nsPFA was non-inferior to \u03bcsPFA in terms of PVI safety and efficacy in the follow-up of 18 swine ablation procedures. Both protocols achieved consistent transmural and circumferential lesion creation without damaging adjacent structures such as the oesophagus or causing phrenic nerve block or paralysis. Additionally, nsPFA induced significantly lower MCs than \u03bcsPFA did in swine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The nsPFA protocol is a demonstrated potential approach for AF ablation, demonstrating comparable safety and efficacy to \u03bcsPFA, with reduced MCs. These findings suggest that nsPFA may offer an equally effective alternative, with significantly reduced MCs, which may translate to lower anaesthesia requirements.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaf171","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:40:10Z","timestamp":1755034810000},"source":"Crossref","is-referenced-by-count":9,"title":["Comparative study of nanosecond and microsecond pulsed field ablation for pulmonary vein isolation in preclinical models"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1111-0769","authenticated-orcid":false,"given":"Hai-yang","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510000 ,","place":["China"]},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology , No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510000 ,","place":["China"]},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology , No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0968-1972","authenticated-orcid":false,"given":"Jianhua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510000 ,","place":["China"]},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology , No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-2361","authenticated-orcid":false,"given":"Yuyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510000 ,","place":["China"]},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology , No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2164-5740","authenticated-orcid":false,"given":"Yong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510000 ,","place":["China"]},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology , No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Tan","sequence":"additional","affiliation":[{"name":"PulseCare Medical Technology Co., Ltd , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510000 ,","place":["China"]},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology , No. 107, Yanjiang West Road, Yuexiu District, Guangzhou 510000 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