{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:20:37Z","timestamp":1791354037994,"version":"4.3.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There are limited prospective randomized studies comparing left bundle branch area pacing (LBBAP) and biventricular (BiV) pacing for cardiac resynchronization therapy (CRT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>The study tested whether LBBAP is noninferior to BiV pacing in patients with Class I indication for CRT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The CSP-SYNC study is an investigator-initiated, randomized, single-center study. Sixty-two patients were randomized 1:1 to LBBAP or BiV. The primary study endpoint was change in left ventricular ejection fraction (LVEF) at 6 months. Secondary endpoints included changes in echo and clinical parameters after 6 months and 12 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thirty-one patients were randomized to each arm. Most patients were males (71%), and 32 % had ischemic cardiomyopathy. At 6 months, similar improvement of LVEF was observed in the LBBAP group compared to the BiV group (14.0% (95% CI: 11.2-16.8) in LBBAP vs. 8.5% (95% CI: 5.6-11.2) in BiV) with mean intergroup difference of 5.6% (95% CI: 1.6-9.5; P&amp;lt;0.001 for noninferiority). Both groups showed comparable decrease in LVESV (-64 ml (95% CI: -78 to -50) vs -40 ml (95% CI: -54 to -25) respectively, mean difference -24 ml (CI 95%: -44 to -4); P&amp;lt;0.001 for noninferiority), changes in 6-minute walk test (P&amp;lt;0.001 for noninferiority) and NYHA class (P=0.011 for noninferiority). Temporal trends of LV remodelling and heart failure hospitalization rates were also comparable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In patients with a Class I indication for CRT, LBBAP was noninferior to BiV pacing in improving LVEF and provided similar structural and electrical remodelling.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaf192","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T16:52:07Z","timestamp":1755967927000},"source":"Crossref","is-referenced-by-count":23,"title":["Conduction system pacing versus biventricular pacing for cardiac resynchronization: the CSP-SYNC randomized single center study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-3989","authenticated-orcid":false,"given":"David","family":"\u017di\u017eek","sequence":"first","affiliation":[{"name":"Cardiology Department, University Medical Centre Ljubljana , Ljubljana ,","place":["Slovenia"]},{"name":"University of Ljubljana, Faculty of Medicine , Ljubljana ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4014-5680","authenticated-orcid":false,"given":"Tadej","family":"\u017dlahti\u010d","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Medical Centre Ljubljana , Ljubljana ,","place":["Slovenia"]},{"name":"University of Ljubljana, Faculty of Medicine , Ljubljana ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-6401","authenticated-orcid":false,"given":"Miha","family":"Mrak","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Medical Centre Ljubljana , Ljubljana ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0189-099X","authenticated-orcid":false,"given":"Maja","family":"Ivanovski","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Medical Centre Ljubljana , Ljubljana ,","place":["Slovenia"]},{"name":"University of Ljubljana, Faculty of Medicine , Ljubljana ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jernej","family":"\u0160tublar","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Medical Centre Ljubljana , Ljubljana ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-5575","authenticated-orcid":false,"given":"Dinko Zavrl","family":"D\u017eananovi\u0107","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Medical Centre Ljubljana , Ljubljana ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0437-946X","authenticated-orcid":false,"given":"Jakob","family":"Peterlin","sequence":"additional","affiliation":[{"name":"University of Ljubljana, Faculty of Medicine , Ljubljana ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-7720","authenticated-orcid":false,"given":"Marta","family":"Cviji\u0107","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Medical Centre Ljubljana , Ljubljana ,","place":["Slovenia"]},{"name":"University of Ljubljana, Faculty of Medicine , Ljubljana ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3650-5986","authenticated-orcid":false,"given":"Anja Zupan","family":"Me\u017enar","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Medical Centre Ljubljana , Ljubljana ,","place":["Slovenia"]},{"name":"University of Ljubljana, Faculty of Medicine , Ljubljana ,","place":["Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,23]]},"container-title":["Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/advance-article-pdf\/doi\/10.1093\/europace\/euaf192\/64114658\/euaf192.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/advance-article-pdf\/doi\/10.1093\/europace\/euaf192\/64114658\/euaf192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T16:52:08Z","timestamp":1755967928000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/advance-article\/doi\/10.1093\/europace\/euaf192\/8240303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/europace\/euaf192","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,23]]},"article-number":"euaf192"}}