{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:21:38Z","timestamp":1792524098394,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Ventricular fibrillation (VF) initiation is influenced by the underlying arrhythmia mechanism. Long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT), Brugada syndrome (BS), and idiopathic ventricular fibrillation (IVF) share overlapping clinical features that often hamper their diagnosis. This study aims to identify distinctive features of VF pattern that may provide additional diagnostic tools to discriminate them.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>We included consecutive patients affected by LQTS, CPVT, BS, or IVF with recurrent VF episodes. The evaluation of VF episodes documented on electrocardiogram or implantable cardioverter-defibrillator recordings allowed us to assess different features of VF episodes including sinus rhythm preceding VF, the trigger\u2019s coupling interval (CI) initiating VF, and the mean cycle length of VF (VFCL) of the 10 first VF beats. Among 2399 patients with LQTS (n = 1587), CPVT (n = 155), BS (n = 584), or IVF (n = 62), 76 episodes of VF were identified in 30 patients. Catecholaminergic polymorphic ventricular tachycardia patients presented higher heart rate preceding VF (CL = 359 \u00b1 26\u2005ms; P &amp;lt; 0.001) and shorter trigger\u2019s CI initiating VF (256 \u00b1 21\u2005ms; P &amp;lt; 0.001). Short-long-short sequence and very long CI (&amp;gt;450\u2005ms) of trigger initiating VF were mostly observed in LQTS (54%; P &amp;lt; 0.001 and 68%, respectively). The VFCL was shorter in CPVT patients (168 \u00b1 15\u2005ms; P &amp;lt; 0.001). Based on these results, we created a discrimination algorithm to support the diagnostic process in clinical practice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Primary electrical diseases display distinct VF patterns. The comprehensive analysis of VF pattern, rather than of isolated VF features, holds then a major potential to support diagnostic accuracy and consequently refine therapeutic strategies in patients and in their relatives.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euaf209","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T05:31:37Z","timestamp":1759210297000},"source":"Crossref","is-referenced-by-count":1,"title":["Distinct patterns of ventricular fibrillation onset in primary electrical diseases: insights from a retrospective multicentre registry"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-6351","authenticated-orcid":false,"given":"Elodie","family":"Surget","sequence":"first","affiliation":[{"name":"Centre hospitalier universitaire Robert Debr\u00e9, Universit\u00e9 Paris Cit\u00e9 , 48 bvd S\u00e9rurier, 75019 Paris ,","place":["France"]},{"name":"Reference Center for Inherited Arrhythmic Syndromes, Centre hospitalier universitaire Bichat, APHP, Universit\u00e9 Paris Cit\u00e9 , 46 rue Henri Huchard, Paris 75018 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wally","family":"Mansogo Ada","sequence":"additional","affiliation":[{"name":"Centre hospitalier universitaire Robert Debr\u00e9, Universit\u00e9 Paris Cit\u00e9 , 48 bvd S\u00e9rurier, 75019 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7950-8090","authenticated-orcid":false,"given":"Alessandra Pia","family":"Porretta","sequence":"additional","affiliation":[{"name":"Centre hospitalier universitaire Robert Debr\u00e9, Universit\u00e9 Paris Cit\u00e9 , 48 bvd S\u00e9rurier, 75019 Paris ,","place":["France"]},{"name":"Service of Cardiology, Heart and Vessel Department, Centre Hospitalier Universitaire Vaudois , Lausanne 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