{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:09:18Z","timestamp":1792642158600,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to assess the risk of haemolysis and the extent of myocardial and neural injury after monopolar, biphasic pulsed field ablation (PFA) using a lattice-tip catheter in comparison to single-shot PF ablation platforms employing bipolar, biphasic waveforms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This prospective study included consecutive patients undergoing PFA for atrial fibrillation (AF) using the Affera\u2122 mapping and ablation system (n = 40). Biomarkers for haemolysis (haptoglobin, lactate dehydrogenase, bilirubin), myocardial injury [high-sensitive troponin T, creatine kinase (CK), creatine kinase MB (CK-MB)], neurocardiac injury (S100), and renal function (creatinine) were assessed pre- and within 24\u2005h post-ablation. A subgroup analysis of first-time pulmonary vein isolation-only procedures compared biomarker changes across Affera\u2122, Farapulse\u2122 (PFA-F), and PulseSelect\u2122 (PFA-P). Post-procedural haemolysis occurred across all PFA platforms. The decrease in \u0394haptoglobin was most pronounced in PFA-F [AfferaTM: (\u2212) 13.8 \u00b1 18.5 vs. PFA-P: (\u2212) 36.8 \u00b1 35.9 vs. PFA-F: (\u2212) 60.7 \u00b1 26.3\u2005mg\/dL, P = &amp;lt;0.001], without haemolysis-related complications. AfferaTM shows a trend towards a higher increase in myocardial injury markers (\u0394troponin, 1537 [580] vs. 970 [1023] vs. 1051 [592] pg\/mL, P = 0.180; \u0394CK, 232 [168] vs. 153 [132] vs. 102 [144] U\/L, P = 0.006; \u0394CK-MB, 28.5 [15.3] vs. 14.6 [12.4] vs. 13.6 [10.5] U\/L, P = 0.055, for Affera TM, PFA-P, and PFA-F, respectively). After ablation, S100 increased in PFA-P and PFA-F, but not in AfferaTM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post-procedural haemolysis after PFA for AF treatment is common and occurs across all PFA platforms. Pulsed field ablation using AfferaTM results in more myocardial injury than bipolar PFA systems with no indication of neural damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euaf210","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:28:21Z","timestamp":1757417301000},"source":"Crossref","is-referenced-by-count":10,"title":["Haemolysis and myocardial and neural injury after monopolar pulsed field ablation using a novel lattice-tip catheter to treat atrial fibrillation"],"prefix":"10.1093","volume":"27","author":[{"given":"Christian","family":"Gold","sequence":"first","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, University Heart and Vascular Center Frankfurt, Goethe University Frankfurt , Theodor-Stern Kai 7, Frankfurt am Main 60590 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Pratz","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, University Heart and Vascular Center Frankfurt, Goethe University Frankfurt , Theodor-Stern Kai 7, Frankfurt am Main 60590 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Falagkari","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, University Heart and Vascular Center Frankfurt, Goethe University Frankfurt , Theodor-Stern Kai 7, Frankfurt am Main 60590 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8614-6857","authenticated-orcid":false,"given":"Victoria","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, University Heart and Vascular Center Frankfurt, Goethe University Frankfurt , Theodor-Stern Kai 7, Frankfurt am Main 60590 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, University Heart and Vascular Center Frankfurt, Goethe University Frankfurt , Theodor-Stern Kai 7, Frankfurt am Main 60590 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine, University Heart and Vascular Center Frankfurt, Goethe University Frankfurt , Theodor-Stern Kai 7, Frankfurt am Main 60590 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7661-4565","authenticated-orcid":false,"given":"Jana","family":"Kupusovic","sequence":"additional","affiliation":[{"name":"Department 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