{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:21:32Z","timestamp":1785450092391,"version":"3.56.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Evaluate the prognostic significance of arrhythmias and conduction disorders on ambulatory ECG in recently diagnosed genetic vs. non-genetic dilated cardiomyopathy (DCM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the prevalence of abnormalities on ambulatory ECG monitoring between genetic and non-genetic DCM patients and evaluate the predictive value for malignant ventricular adverse events (MVAEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Clinical and ambulatory ECG data were collected from 354 genotyped DCM probands, with a median follow-up of 8 years (IQR: 5\u20139 years). The malignant ventricular adverse event was defined as ventricular fibrillation, sustained ventricular tachycardia, anti-tachy pacing, appropriate device therapy, or sudden cardiac death. C-statistics assessed the predictive performance of the regression models. In total, 123 (35%) patients carried a (likely) pathogenic variant. Abnormalities on ambulatory ECG were more frequent in genetic DCM patients (80%) compared to non-genetic DCM (67%; P = 0.013). Permanent atrial fibrillation (perAF), paroxysmal supraventricular tachycardia (parox-SVT), and non-sustained ventricular tachycardia (NSVT) were more frequent in genetic DCM patients (P = 0.041, &amp;lt;0.001, and &amp;lt;0.001). Structural cardiac parameters showed minimal group differences. Using Cox proportional hazard analyses to predict MVAE, ambulatory ECG variables (perAF, AV-block, NSVT, &amp;gt;500 premature ventricular complexes (PVCs)\/24\u2005h) had an area under the curve (AUC) of 0.768 in genetic and 0.628 in non-genetic DCM patients (P = 0.044). The premature ventricular complex burden was only predictive for MVAE in genetic DCM. Adding clinical variables provided little incremental predictive value for genetic vs. non-genetic DCM (AUC \u0394+0.004 vs. \u0394+0.150, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ambulatory ECG monitoring abnormalities are prevalent in genetic DCM patients. In contrast to non-genetic DCM patients, ambulatory ECG parameters have an important predictive value to determine the risk of MVAE in genetic DCM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euaf279","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T13:17:41Z","timestamp":1762435061000},"source":"Crossref","is-referenced-by-count":1,"title":["Predictive value of ambulatory ECG monitoring for malignant arrhythmic events in genetic dilated cardiomyopathy"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2574-6672","authenticated-orcid":false,"given":"Max F G H M","family":"Venner","sequence":"first","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Universiteitssingel 50 , 6229ER Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0030-6444","authenticated-orcid":false,"given":"Astrid B M","family":"Heymans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Universiteitssingel 50 , 6229ER Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0605-4604","authenticated-orcid":false,"given":"Nina J","family":"Beelen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Universiteitssingel 50 , 6229ER Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0965-6359","authenticated-orcid":false,"given":"Sophie L V M","family":"Stroeks","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Universiteitssingel 50 , 6229ER Maastricht ,","place":["The Netherlands"]},{"name":"Department of Clinical Genetics, Maastricht University Medical Centre+ , Universiteitssingel 40, 6229ER Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4784-6189","authenticated-orcid":false,"given":"Isa M E","family":"Faassen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Universiteitssingel 50 , 6229ER Maastricht ,","place":["The Netherlands"]},{"name":"Department of Clinical Genetics, Maastricht University Medical Centre+ , Universiteitssingel 40, 6229ER Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8165-6631","authenticated-orcid":false,"given":"Maurits A","family":"Sikking","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Universiteitssingel 50 , 6229ER Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-071X","authenticated-orcid":false,"given":"Michiel T H M","family":"Henkens","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Universiteitssingel 50 , 6229ER Maastricht ,","place":["The Netherlands"]},{"name":"Department of Pathology, Maastricht University Medical Centre+ , Maastricht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8619-1511","authenticated-orcid":false,"given":"Saskia N","family":"van der Crabben","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Maastricht University Medical Centre+ , Universiteitssingel 40, 6229ER Maastricht ,","place":["The Netherlands"]},{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Meibergdreef 9, 1105 AZ Amsterdam, The \u00a0","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9228-8045","authenticated-orcid":false,"given":"Anne G","family":"Raafs","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Universiteitssingel 50 , 6229ER Maastricht ,","place":["The Netherlands"]},{"name":"Department of Cardiology, Catharina Hospital , Eindhoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-7803","authenticated-orcid":false,"given":"Stephane R B","family":"Heymans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Universiteitssingel 50 , 6229ER Maastricht ,","place":["The Netherlands"]},{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart (ERN GUARD-Heart), Meibergdreef 9, 1105 AZ Amsterdam, The \u00a0","place":["Netherlands"]},{"name":"Centre of Cardiovascular Research, Centre for Molecular and Vascular Biology, University of Leuven , Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-1298","authenticated-orcid":false,"given":"Job A J","family":"Verdonschot","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Universiteitssingel 50 , 6229ER Maastricht ,","place":["The Netherlands"]},{"name":"Department of Clinical Genetics, Maastricht University Medical Centre+ , Universiteitssingel 40, 6229ER Maastricht ,","place":["The Netherlands"]},{"name":"European Reference Network for 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