{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:31:33Z","timestamp":1792812693862,"version":"4.5.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With the introduction of pulsed field ablation (PFA) to treat atrial fibrillation (AF), there is interest in studying workflow and sedation strategies to optimize integration into clinical practice. This sub-analysis characterizes early real-world use of general anesthesia versus deep sedation during AF ablation using the pentaspline PFA catheter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EU-PORIA is an all-comer AF registry enrolling consecutive patients at seven high-volume centers in Europe. Patients were treated based on institutional standard-of-care. During follow-up, any episode of atrial tachycardia (AT) or AF &amp;gt;30s was considered an arrhythmia recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>EU-PORIA enrolled 1233 patients, of which 250 (20%) and 983 (80%) cases were performed using general anesthesia and deep sedation, respectively. Patients treated with general anesthesia were more often male and non-paroxysmal AF. In the general anesthesia group, 72% received pulmonary vein isolation (PVI)-only versus 90% in the deep sedation group (p&amp;lt;0.01), and 3D mapping was used in 60% of general anesthesia and 27% of deep sedation cases (p&amp;lt;0.01). Procedure and fluoroscopy times were shorter with deep sedation (51[36-84] vs 75[60-90] min; 13[8-19] vs 19[15-26] min; p&amp;lt;0.01). There were no differences in the incidence of serious adverse events. At 1-year follow-up, 74.8% and 73.8% of patients in the general anesthesia and deep sedation groups, respectively, were free from recurrent AF\/AT (p=0.87).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AF ablation using deep sedation with the pentaspline PFA catheter demonstrated a safety and efficacy profile consistent with procedures performed under general anesthesia. This characterization of real-world use warrants further evaluation to understand optimal sedation strategies with PFA technologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euaf287","type":"journal-article","created":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T12:56:40Z","timestamp":1763297800000},"source":"Crossref","is-referenced-by-count":15,"title":["Characterization of sedation strategies in real-world use of pulsed field ablation Sub-analysis of the EU-PORIA registry"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-6015","authenticated-orcid":false,"given":"Kyoung Ryul Julian","family":"Chun","sequence":"first","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien, Wilhelm-Epstein Str. 4 , 60431 Frankfurt ,","place":["Germany"]},{"name":"Universit\u00e4tsklinikum L\u00fcbeck, Klinik f\u00fcr Rhythmologie , L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Plank","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien, Wilhelm-Epstein Str. 4 , 60431 Frankfurt ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2075-8113","authenticated-orcid":false,"given":"Kars","family":"Neven","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Alfried Krupp Hospital , Essen ,","place":["Germany"]},{"name":"Department of Medicine, Witten\/Herdecke University , Witten ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-8415","authenticated-orcid":false,"given":"Tobias","family":"Reichlin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Blaauw","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen, University Medical Center Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6600-9006","authenticated-orcid":false,"given":"Jim","family":"Hansen","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology, Gentofte Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8843-9370","authenticated-orcid":false,"given":"Raquel","family":"Adelino","sequence":"additional","affiliation":[{"name":"Heart Rhythm Department, Clinique Pasteur , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7405-822X","authenticated-orcid":false,"given":"Alexandre","family":"Ouss","sequence":"additional","affiliation":[{"name":"Heart Center Catharina Hospital , Eindhoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0282-4658","authenticated-orcid":false,"given":"Stefano","family":"Bordignon","sequence":"additional","affiliation":[{"name":"Cardioangiologisches Centrum Bethanien, Wilhelm-Epstein Str. 4 , 60431 Frankfurt ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2116-1690","authenticated-orcid":false,"given":"Anna","family":"F\u00fcting","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Alfried Krupp Hospital , Essen ,","place":["Germany"]},{"name":"Department of Medicine, Witten\/Herdecke University , Witten ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-1329","authenticated-orcid":false,"given":"Laurent","family":"Roten","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4411-3918","authenticated-orcid":false,"given":"Bart A","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen, University Medical Center Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1541-309X","authenticated-orcid":false,"given":"Martin H","family":"Ruwald","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology, Gentofte Hospital , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1671-1977","authenticated-orcid":false,"given":"Roberto","family":"Men\u00e9","sequence":"additional","affiliation":[{"name":"Heart Rhythm Department, Clinique Pasteur , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0927-3406","authenticated-orcid":false,"given":"Pepijn","family":"van der Voort","sequence":"additional","affiliation":[{"name":"Heart Center Catharina Hospital , Eindhoven ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7385-2691","authenticated-orcid":false,"given":"Nico","family":"Reinsch","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Alfried Krupp Hospital , Essen ,","place":["Germany"]},{"name":"Department of Medicine, Witten\/Herdecke University , 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