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To reduce its impact on patients\u2019 lives, improvements in stroke prevention therapy, treatment of concomitant conditions, and rhythm control therapy are actively developed: Innovations in anti-thrombotic agents, new anti-arrhythmic drugs (AADs), and novel interventional rhythm control therapies emerge alongside AF-reducing effects of general cardiometabolic therapies. Simple risk scores are slowly replaced by personalized AF risk estimation using quantifiable features. These developments were discussed by over 80 experts from academia and industry during the 10th Atrial Fibrillation NETwork \/European Heart Rhythm Association consensus conference from 5 to 7 May 2025. The emerging consensus, described here, is multi-domain therapy combining stroke prevention, rhythm control, and therapy of concomitant cardiovascular conditions. This combines anti-coagulants, AADs, and AF ablation with old and new cardiometabolic drugs that can reduce AF risk, AF burden, and AF-related complications at scale. The paper furthermore describes quantitative traits that may enable a shift towards risk-driven therapy based on AF phenotypes. These can enable adjusted therapy strategies that are safe, accessible, and patient-centred. Applying modern data science and artificial intelligence methods to quantitative phenotypic and genetic features can further improve risk estimation and personalized therapy selection. At the same time, translational and clinical research into reversing the drivers of AF and into improved stroke prevention through new drugs and through combination therapies is needed. Together, these efforts offer pathways towards personalized, patient-centred, multi-modal, and accessible AF management that integrates rhythm control, stroke prevention, and therapy of concomitant conditions to bridge today\u2019s practical needs with tomorrow\u2019s therapeutic innovation.<\/jats:p>","DOI":"10.1093\/europace\/euaf318","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:00:38Z","timestamp":1765544438000},"source":"Crossref","is-referenced-by-count":26,"title":["Transforming atrial fibrillation management by targeting comorbidities and reducing atrial fibrillation burden: the 10th AFNET\/EHRA consensus conference"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-0870","authenticated-orcid":false,"given":"Emma","family":"Svennberg","sequence":"first","affiliation":[{"name":"Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-1903","authenticated-orcid":false,"given":"Jose Luis","family":"Merino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, La Paz University Hospital, IDIPaz, Universidad Autonoma , Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8493-5123","authenticated-orcid":false,"given":"Jason","family":"Andrade","sequence":"additional","affiliation":[{"name":"Vancouver General Hospital , Vancouver ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6311-4270","authenticated-orcid":false,"given":"Matteo","family":"Anselmino","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department, Department of Medical Sciences, Citt\u00e0 della Salute e della Scienza di Torino Hospital, University of Turin, Turin ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0424-6393","authenticated-orcid":false,"given":"Elena","family":"Arbelo","sequence":"additional","affiliation":[{"name":"Arrhythmia Section, Cardiology Department, Hospital Cl\u00ednic, Universitat de Barcelona , Barcelona ,","place":["Spain"]},{"name":"Institut d\u2019Investigaci\u00f3 August Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Madrid ,","place":["Spain"]},{"name":"European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart\u2014ERN GUARD-Heart"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2559-7128","authenticated-orcid":false,"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, 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