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This narrative review explores recent developments in computer-aided techniques for characterizing the arrhythmogenic substrate, focusing on post-myocardial infarction VT. High-resolution cardiac imaging now enables detailed visualization of structural abnormalities, including heterogeneous scar architecture and fatty infiltration. Sophisticated invasive mapping techniques provide insights into local electrophysiological properties, while novel non-invasive mapping approaches offer complementary views of global electrical patterns. Integration of these modalities through computational simulations allows for mechanistic insights into arrhythmia initiation and maintenance, particularly in post-myocardial infarction VT, where structural and functional substrates interact in complex ways. Emerging artificial intelligence applications enhance substrate analysis through automated feature extraction and pattern recognition, enabling more sophisticated risk stratification. These computer-aided approaches are advancing from research tools to clinical applications, with early evidence suggesting improved ablation outcomes and better risk prediction. However, significant challenges remain in validation, standardization, and clinical implementation of these innovations. This narrative review highlights recent methodological advances and clinical applications of computer-aided substrate characterization, and conceptualizes future directions towards personalized arrhythmia management, also beyond post-infarction VTs.<\/jats:p>","DOI":"10.1093\/europace\/euag003","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:41:20Z","timestamp":1767876080000},"source":"Crossref","is-referenced-by-count":3,"title":["Computer-aided characterization of the arrhythmogenic substrate after myocardial infarction"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-7829","authenticated-orcid":false,"given":"Manon","family":"Kloosterman","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht , Utrecht ,","place":["The 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Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2358-0170","authenticated-orcid":false,"given":"Veronique M F","family":"Meijborg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]},{"name":"Department of Medical Physiology, University Medical Center Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Bhagirath","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam , Amsterdam ,","place":["The 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