{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:18:36Z","timestamp":1791533916304,"version":"4.3.4"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_197595"],"award-info":[{"award-number":["310030_197595"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020401","name":"Bern Center of Precision Medicine Lighthouse Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["#394630089"],"award-info":[{"award-number":["#394630089"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Electromechanical coupling and mechano-electrical feedback (MEF) are crucial for cardiac function, but their pro-arrhythmic roles in short and long QT syndromes (SQT1 and LQT2) are not fully understood. We aimed to evaluate MEF-induced electrical changes, their arrhythmic impact, and the involvement of stretch-activated channels (SACs) in transgenic rabbit models of SQT1 and LQT2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patch-clamp and fluorescence imaging were used to analyse action potential duration (APD), Ca\u00b2\u207a transients, and contractility in ventricular cardiomyocytes (VCMs) from LQT2, SQT1 and wild-type (WT) rabbits. LQT2 cells showed prolonged APD and Ca\u00b2\u207a transients, increased early afterdepolarizations, Ca\u00b2\u207a oscillations, and impaired mechanics compared to WT and SQT1. The cellular electromechanical window (Ca\u00b2\u207a-transient duration minus APD) was more negative in LQT2 and more positive in SQT1 than in WT. QTc prolonged with preload\/afterload increase and decreased with preload reduction across all genotypes, but MEF-induced QTc changes and dispersion were most pronounced in LQT2.<\/jats:p>\n                    <jats:p>Ex vivo Langendorff experiments showed that increased right ventricular (RV) pressure prolonged APD and QTc in WT hearts. This was attenuated by the SAC blocker GSMTx4, suggesting a role for SACs in MEF.<\/jats:p>\n                    <jats:p>In silico models of human VCMs including SACs confirmed higher vulnerability to stretch\/MEF-induced arrhythmias, including re-entry, in SQT1 and LQT2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Mechano-electrical feedback-induced electrical changes, partly mediated by SACs, occur in WT, SQT1, and LQT2, but MEF effects are strongest in LQT2. Mechano-electrical feedback induces pro-arrhythmic effects in silico more prominently in LQT2 and SQT1 than in WT, highlighting the potential pro-arrhythmic role of MEF in a vulnerable electrophysiological substrate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euag011","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:54:58Z","timestamp":1768481698000},"source":"Crossref","is-referenced-by-count":1,"title":["Mechano-electrical feedback in transgenic rabbit models of long QT syndrome Type 2 and short QT syndrome Type 1"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4929-3479","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Alerni","sequence":"first","affiliation":[{"name":"Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern and University of Bern , Buehlplatz 5, Bern CH-3012 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Brown University , Providence, RI ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3802-3158","authenticated-orcid":false,"given":"Ruben","family":"Lopez","sequence":"additional","affiliation":[{"name":"Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern and University of Bern , Buehlplatz 5, Bern CH-3012 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Zehender","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology I, University Heart Center Freiburg, University Medical Center Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0287-9560","authenticated-orcid":false,"given":"Michael","family":"Brunner","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology I, University Heart Center Freiburg, University Medical Center Freiburg , Freiburg ,","place":["Germany"]},{"name":"Department of Cardiology, Rhythmology and Intensive Care, St. Josef Krankenhaus Freiburg , Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-3079","authenticated-orcid":false,"given":"Bal\u00e1zs","family":"\u00d6rd\u00f6g","sequence":"additional","affiliation":[{"name":"Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern and University of Bern , Buehlplatz 5, Bern CH-3012 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1418-108X","authenticated-orcid":false,"given":"Jordi","family":"Heijman","sequence":"additional","affiliation":[{"name":"Gottfried Schatz Research Center, Division of Medical Physics & Biophysics, Medical University of Graz , Graz 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