{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:21:31Z","timestamp":1772821291032,"version":"3.50.1"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate differences in clinical characteristics and outcomes based on physical activity levels in patients with atrial fibrillation (AF), comparing Europeans and Asians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Post-hoc analysis of two prospective registries from Europe and the Asia-Pacific. Patients were classified as inactive (no exercise or &amp;lt;3\u2005h\/week) or active (\u22653\u2005h\/week). The primary outcome was a composite of all-cause death and major adverse cardiovascular events (MACE). Secondary outcomes included all-cause death, MACE, major bleeding, individual MACE components. Cox model estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes. Subgroup analyses were performed by clinically relevant variables and enrolment setting. Of 13 126 participants (69 \u00b1 12 years; 39% female), 3639 (28%) were physically active and 9487 (72%) physically inactive. Across both groups, Asians had lower odds of obesity, symptomatic AF and heart failure, but higher odds of cardiovascular risk factors than Europeans. After a median follow-up of 514 days, physically active AF patients had a lower risk of composite outcome (HR 0.66, 95%CI 0.56\u20130.78), all-cause death (HR 0.52, 95%CI 0.42\u20130.65), MACE (HR 0.80, 95%CI 0.65\u20130.99), cardiovascular death (HR 0.60, 95%CI 0.42\u20130.86), with no significant differences between Europeans and Asians (pinteraction for composite outcome = 0.298). The risk of the composite outcome decreased progressively with increasing levels of physical activity, with no significant differences between Europeans and Asians (pinteraction = 0.845).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with AF, self-reported physical activity is associated with a lower risk of adverse events, consistently across Europe and Asia. Physical activity may represent a component of a lower-risk clinical profile in AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euag032","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:38:37Z","timestamp":1771591117000},"source":"Crossref","is-referenced-by-count":0,"title":["Physical activity and risk of adverse events in atrial fibrillation: evidence from European and Asian cohorts"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6454-2736","authenticated-orcid":false,"given":"Michele","family":"Rossi","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , 6 West Derby Street, Liverpool L7 8TX ,","place":["UK"]},{"name":"Department of Life, Health & Environmental Sciences, University of L\u2019Aquila , L\u2019Aquila ,","place":["Italy"]},{"name":"Internal Medicine and Nephrology Division, ASL1 Avezzano-Sulmona-L\u2019Aquila, San Salvatore Hospital , L\u2019Aquila ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2895-6234","authenticated-orcid":false,"given":"Tommaso","family":"Bucci","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , 6 West Derby Street, Liverpool L7 8TX ,","place":["UK"]},{"name":"Internal, Vascular and Emergency Medicine \u2013 Stroke Unit, University of Perugia , Perugia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7655-8651","authenticated-orcid":false,"given":"Enrico","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , 6 West Derby Street, Liverpool L7 8TX ,","place":["UK"]},{"name":"Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena , Modena ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2803-079X","authenticated-orcid":false,"given":"Amir","family":"Askarinejad","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , 6 West Derby Street, Liverpool L7 8TX ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven Ho Man","family":"Lam","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , 6 West Derby Street, Liverpool L7 8TX ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7119-1254","authenticated-orcid":false,"given":"Andrea Galeazzo","family":"Rigutini","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital , 6 West Derby Street, Liverpool L7 8TX ,","place":["UK"]},{"name":"Internal, Vascular and Emergency Medicine \u2013 Stroke Unit, University of Perugia , Perugia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Ferri","sequence":"additional","affiliation":[{"name":"Department of Life, Health & Environmental Sciences, University of L\u2019Aquila , L\u2019Aquila ,","place":["Italy"]},{"name":"Internal Medicine and Nephrology Division, ASL1 Avezzano-Sulmona-L\u2019Aquila, San Salvatore Hospital 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