{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:55:11Z","timestamp":1792155311539,"version":"4.4.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017957","name":"Guizhou Provincial Health Commission","doi-asserted-by":"publisher","award":["gzwkj2020-1-070"],"award-info":[{"award-number":["gzwkj2020-1-070"]}],"id":[{"id":"10.13039\/100017957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Conventional left atrial appendage occlusion (LAAO) procedures typically require transoesophageal echocardiography and general anaesthesia, which may limit feasibility in resource-limited settings. Simplified LAAO (sLAAO) guided exclusively by fluoroscopy offers a practical and efficient alternative. This study evaluated procedural safety, efficacy, and short-term outcomes of sLAAO using the WATCHMAN FLX device under exclusive fluoroscopic guidance in a real-world, multicentre setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The ROSE-FLX study was a prospective, multicentre, single-arm registry including 400 patients with non-valvular atrial fibrillation at high thromboembolic and bleeding risk. All underwent sLAAO under local anaesthesia and exclusive fluoroscopic guidance. Procedural data, peri-procedural complications, and follow-up outcomes were analysed. Predictors of adverse events were determined using Cox regression. Procedural success was 100%, with low major complication rates: pericardial effusion (0.5%), access-site complications (1.3%), and major bleeding (0.8%). Over median follow-up of 194.5 days [interquartile range (IQR) 129.0\u2013265.0], all-cause mortality occurred in three patients (0.8%), transient ischaemic attacks in 13 patients (3.3%), and device-related thrombosis in one patient (0.3%). In multivariable Cox regression, chronic obstructive pulmonary disease (HR 2.86, 95% CI 1.98\u20134.11, P &amp;lt; 0.001) and higher CHA2DS2-VASc scores (HR 4.69, 95% CI 1.90\u201311.57, P &amp;lt; 0.001) independently predicted adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Exclusive fluoroscopy-guided sLAAO with the WATCHMAN FLX device is feasible, safe, and resource efficient, achieving high procedural success and low complication rates, suggesting that this approach may be considered in selected centres lacking advanced echocardiographic or anaesthetic support, pending confirmation from comparative studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euag045","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:54:16Z","timestamp":1780077256000},"source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of simplified left atrial appendage occlusion using the WATCHMAN FLX device: the ROSE-FLX study"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6963-5918","authenticated-orcid":false,"given":"Wei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Guizhou Medical University , No. 9 Beijing Road, Yunyan District, Guiyang, Guizhou 550004 ,","place":["China"]},{"name":"Department of Cardiology, The Affiliated Hospital of Guizhou Medical University , No. 28 Beijing Road, Guiyang, Guizhou 550004 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Medicine, Guizhou Medical University , No. 9 Beijing Road, Yunyan District, Guiyang, Guizhou 550004 ,","place":["China"]},{"name":"Department of Cardiology, The Affiliated Hospital of Guizhou Medical University , No. 28 Beijing Road, Guiyang, Guizhou 550004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Guizhou Medical University , Kaili, Guizhou 556000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The People\u2019s Hospital of Liupanshui City , Liupanshui, Guizhou 553000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Qiannan Prefecture Hospital of 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550004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Guizhou Medical University , No. 9 Beijing Road, Yunyan District, Guiyang, Guizhou 550004 ,","place":["China"]},{"name":"Department of Cardiology, The Affiliated Hospital of Guizhou Medical University , No. 28 Beijing Road, Guiyang, Guizhou 550004 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Guizhou Medical University , No. 9 Beijing Road, Yunyan District, Guiyang, Guizhou 550004 ,","place":["China"]},{"name":"Department of Cardiology, The Affiliated Hospital of Guizhou Medical University , No. 28 Beijing Road, Guiyang, Guizhou 550004 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