{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:54:34Z","timestamp":1791305674664,"version":"4.3.1"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["ISF 833\/23"],"award-info":[{"award-number":["ISF 833\/23"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Israel Heart Society"},{"DOI":"10.13039\/501100005005","name":"Ben-Gurion University of the Negev","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is strongly associated with adverse outcomes, particularly in patients with heart failure (HF). AF susceptibility is driven by atrial remodelling, including electrical disarray, inflammation, and fibrosis, yet current therapies do not adequately target the underlying substrate. Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, and colchicine, a broad-spectrum anti-inflammatory agent, have demonstrated cardiovascular benefits, but their effects on atrial remodelling remain unclear. We evaluated the effects of both drugs on atrial remodelling in post-myocardial infarction (MI) rats with reduced ejection fraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Male rats underwent MI together with implantation of a chronic atrial pacing and recording system. One-week post-MI, animals with left ventricular ejection fraction \u226440% were randomized to semaglutide (40\u2005\u00b5g\/kg subcutaneously every 72\u2005h), colchicine (100\u2005\u00b5g\/kg intraperitoneally daily), or vehicle for 21 days. Serial electrophysiological testing, echocardiography, histology, and molecular analyses were performed to characterize the AF substrate. Both semaglutide and colchicine reduced AF inducibility and AF duration, whereas semaglutide additionally reduced atrial signal complexity. Semaglutide attenuated atrial fibrosis, suppressed NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome expression, prevented connexin-43 (Cx43) lateralization, and reduced expression of the proarrhythmic small-conductance calcium-activated potassium channel 4 (SK4). Colchicine reduced NLRP3 and SK4 expression and inhibited p38, c-Jun N-terminal kinase (JNK), and protein kinase B (AKT) signalling, but did not prevent fibrosis or Cx43 remodelling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the post-MI HF setting, both drugs demonstrated anti-arrhythmic and anti-remodelling effects. Their differential actions suggest that multiple pathways can be targeted to limit AF substrate progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euag091","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:34:24Z","timestamp":1776432864000},"source":"Crossref","is-referenced-by-count":2,"title":["Differential effects of semaglutide and colchicine on atrial remodeling in rats with reduced ejection fraction after myocardial infarction"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8719-7721","authenticated-orcid":false,"given":"Or","family":"Levi","sequence":"first","affiliation":[{"name":"Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]},{"name":"Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1018-2299","authenticated-orcid":false,"given":"Noam","family":"Dalal","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]},{"name":"Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9912-1941","authenticated-orcid":false,"given":"Aviv","family":"Komissar","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]},{"name":"Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6121-7050","authenticated-orcid":false,"given":"Daniel","family":"Moldavsky","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]},{"name":"Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9505-140X","authenticated-orcid":false,"given":"Salma","family":"Khamaisi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]},{"name":"Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5498-2906","authenticated-orcid":false,"given":"Sigal","family":"Elyagon","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]},{"name":"Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7531-1474","authenticated-orcid":false,"given":"Michael","family":"Murninkas","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]},{"name":"Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7164-4116","authenticated-orcid":false,"given":"Adir","family":"Eliyahu","sequence":"additional","affiliation":[{"name":"Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-1435","authenticated-orcid":false,"given":"Shira","family":"Burg","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1066-7047","authenticated-orcid":false,"given":"Bernard","family":"Attali","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0932-3081","authenticated-orcid":false,"given":"Daria","family":"Makarovsky","sequence":"additional","affiliation":[{"name":"Inter-Departmental Core Facility, Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Lichtenstein","sequence":"additional","affiliation":[{"name":"Inter-Departmental Core Facility, Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2244-5508","authenticated-orcid":false,"given":"Gideon","family":"Gradwohl","sequence":"additional","affiliation":[{"name":"Medical Engineering Unit, The Jerusalem College of Technology , Jerusalem ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4234-6504","authenticated-orcid":false,"given":"Gal","family":"Tsaban","sequence":"additional","affiliation":[{"name":"Cardiology Section, Soroka University Medical Center , Beer-Sheva ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0587-3241","authenticated-orcid":false,"given":"Yana","family":"Kakzanov","sequence":"additional","affiliation":[{"name":"Cardiology Department, Samson Assuta Ashdod University Medical Center , Ashdod ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6548-0661","authenticated-orcid":false,"given":"Avishag","family":"Laish-Farkash","sequence":"additional","affiliation":[{"name":"Cardiology Department, Samson Assuta Ashdod University Medical Center , Ashdod ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Etzion","sequence":"additional","affiliation":[{"name":"Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9930-1035","authenticated-orcid":false,"given":"Yoram","family":"Etzion","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. Box 653, Beer-Sheva 8410501 ,","place":["Israel"]},{"name":"Regenerative Medicine & Stem Cell Research Center, Ben-Gurion University of the Negev , David Ben-Gurion Blvd. 1, P.O. 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