{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:47:32Z","timestamp":1782906452940,"version":"3.54.5"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon Europe research and innovation programme","award":["101137129"],"award-info":[{"award-number":["101137129"]}]},{"name":"French Government","award":["ANR-10-IAHU-04"],"award-info":[{"award-number":["ANR-10-IAHU-04"]}]},{"name":"Tr\u00e8s Grand Centre de Calcul du CEA"},{"DOI":"10.13039\/501100010190","name":"Grand \u00c9quipement National de Calcul Intensif","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["900008"],"award-info":[{"award-number":["900008"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Interatrial connections (IACs) may act as pathways sustaining atrial fibrillation (AF), yet their role as ablation targets remains uncertain due to challenges in identifying IAC-dependent re-entrant circuits. This study tracks re-entrant activity along IACs, characterizes IAC-dependent re-entries, and assesses the impact of in silico IAC ablation on re-entry maintenance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Six patient-specific biatrial bilayer models were reconstructed from CT and MRI-derived geometries, each incorporating four IACs: Bachmann\u2019s bundle, fossa ovalis, upper posterior, and coronary sinus. The Courtemanche ionic model was used to simulate mild (M) and severe (S) AF-related electrical remodelling, with fibrosis burden ranging from 9.0% (M) to 27.6% (S). Across the 12 models, 110 sustained re-entries were induced, followed by circumferential pulmonary vein isolation. Fifteen IAC ablation strategies were tested at three different timings. Critical pathways along the six possible interatrial loops were quantified. Tachycardia cycle length (TCL) and phase singularity (PS) clusters were analysed before and after IAC ablation. Overall, 11.8% of re-entries were IAC-dependent. Larger interatrial loops were the major contributors to critical pathway formation. IAC-dependent re-entries exhibited more critical pathways, shorter TCL (194.2 vs. 201.9\u2005ms; \u0394TCL = 7.65\u2005ms, P = 0.006), and more PS clusters in the RA body [8 (5\u201310) vs. 4 (2\u20136), P = 0.006]. Ablation timing did not influence termination rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We present the first framework to track re-entrant activity along IACs. We identified IAC-dependent re-entry characteristics that may guide patient stratification and targeted ablation strategies in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euag145","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:57:22Z","timestamp":1781513842000},"source":"Crossref","is-referenced-by-count":0,"title":["Role of interatrial connection ablation in re-entry dynamics: an in silico evaluation"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9762-2982","authenticated-orcid":false,"given":"Patricia","family":"Mart\u00ednez D\u00edaz","sequence":"first","affiliation":[{"name":"IHU-LIRYC, L\u2019Institut de RYthmologie et Mod\u00e9lisation Cardiaque, Fondation University of Bordeaux , Talence ,","place":["France"]},{"name":"Institute of Mathematics of Bordeaux, UMR 5251, University of Bordeaux , Talence 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