{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:08:22Z","timestamp":1788800902677,"version":"build-2803163510"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Continuous cardiac monitoring with implantable loop recorders (ILRs) is recommended after cryptogenic stroke to detect occult atrial fibrillation (AF). We aimed to develop and validate a dedicated risk score for AF detection in patients undergoing ILR monitoring after cryptogenic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This multicentre study enrolled 1002 consecutive patients (mean age 66.0 \u00b1 12.3 years, 57.9% male) who received an ILR after cryptogenic stroke. The primary outcome was a first episode of AF or atrial tachycardia (AT). A score was developed in a randomly split development cohort and validated internally, accounting for competing risks, missing data imputation, and hazard ratio-based weighting. Among the 668 patients in the development cohort, cumulative incidences of AF\/AT at 1, 2, and 3 years were 20.3%, 28.9%, and 33.0%, respectively. Four independent predictors were identified: premature atrial contractions &amp;gt; 200\/24\u2005h on Holter-ECG (2 points), age &amp;gt;58\u201378 years (3 points) or &amp;gt; 78 years (4 points), significant valvular heart disease (1 point), and left atrial dilatation (2 points), forming the PAVA (premature atrial contractions, age, significant valvular heart disease, and left atrial dilatation) score. Discrimination was good in both the development and validation cohorts (c-index 0.73 and 0.79, respectively). The 3-year areas under the curve were 0.800 and 0.905, respectively. A PAVA score \u2264 2, observed in 23.6% of patients, yielded negative predictive values of 89.2% and 100% in the development and validation cohorts. ROC-curve analysis confirmed superior clinical utility over existing scores (Brown ESUS-AF [Brown embolic stroke of undetermined source-atrial fibrillation], HAVOC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A PAVA score \u2264 2 demonstrates a high negative predictive value for AF\/AT on ILR after cryptogenic stroke, offering a practical tool to optimize patient prioritization for ILR implantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euag183","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:09:21Z","timestamp":1788520161000},"source":"Crossref","is-referenced-by-count":0,"title":["Identifying patients at low risk for atrial fibrillation after cryptogenic stroke: the PAVA score"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2639-9593","authenticated-orcid":false,"given":"Baptiste","family":"Maille","sequence":"first","affiliation":[{"name":"Rhythmology Department, CHU La Timone , 264 Rue Saint-Pierre, 13005 Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0816-4053","authenticated-orcid":false,"given":"No\u00e9mie","family":"Resseguier","sequence":"additional","affiliation":[{"name":"CEReSS-Health Service Research and Quality of Life Center, School of Medicine, Aix-Marseille University , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7227-3428","authenticated-orcid":false,"given":"Eloi","family":"Marijon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, European Georges Pompidou Hospital , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7529-8735","authenticated-orcid":false,"given":"Nathalie","family":"Behar","sequence":"additional","affiliation":[{"name":"Rennes University Hospital, Department of Cardiology , Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4199-4019","authenticated-orcid":false,"given":"Marc","family":"Badoz","sequence":"additional","affiliation":[{"name":"Cardiology Department, CHU Besan\u00e7on , Besan\u00e7on ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Vuillier","sequence":"additional","affiliation":[{"name":"Neurology Department, CHU Besan\u00e7on , Besan\u00e7on ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Malrain","sequence":"additional","affiliation":[{"name":"Rennes University Hospital, Department of Neurology , Rennes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Grygorowicz","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe, CHU Dijon Bourgogne, Service de Cardiologie , EA7460 PEC2, 21000 Dijon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5050-2354","authenticated-orcid":false,"given":"Victor","family":"Klein","sequence":"additional","affiliation":[{"name":"Rhythmology Department, CHU La Timone , 264 Rue Saint-Pierre, 13005 Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4823-1556","authenticated-orcid":false,"given":"Aymeric","family":"Menet","sequence":"additional","affiliation":[{"name":"Cardiology Department, Groupe Hospitalier Institut Catholique de Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5905-2591","authenticated-orcid":false,"given":"Maryam","family":"Dridi","sequence":"additional","affiliation":[{"name":"Cardiology Department, Groupe Hospitalier Institut Catholique de Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6289-0799","authenticated-orcid":false,"given":"Christelle","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, H\u00f4pital Cardiologique Louis Pradel, Hospices Civils de Lyon , 28 avenue du Doyen Lepine, Bron 69500 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Calvet","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Unit, GHU-Paris Psychiatrie et Neurosciences, H\u00f4pital Sainte-Anne, Universit\u00e9 de Paris Cit\u00e9, INSERM U1266, Institute of Psychiatry and Neuroscience , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Suissa","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Unit, CHU La Timone , Marseille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6425-9343","authenticated-orcid":false,"given":"Luciano A","family":"Sposato","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University , London, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-3845","authenticated-orcid":false,"given":"Jean-Claude","family":"Deharo","sequence":"additional","affiliation":[{"name":"Rhythmology Department, CHU La Timone , 264 Rue Saint-Pierre, 13005 Marseille 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