{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:08:38Z","timestamp":1788952118727,"version":"build-2803163510"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016242","name":"Boston Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) ablation by pulmonary vein isolation (PVI) and left atrial appendage closure (LAAC) are increasingly performed as standalone procedures. Given that PVI and LAAC share the same access route, a combined approach of pulsed field ablation (PFA)-based PVI and LAAC might be beneficial. The COCONUT study focused on safety, efficacy, and outcomes combining PVI by PFA with LAAC in one procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective, multinational registry study. The primary endpoints were the following: (1) primary safety endpoint: serious adverse events; and (2) primary efficacy endpoint: success of PVI and LAA closure defined as the ability to isolate all pulmonary veins and the successful closure of the LAA. For secondary endpoints, peri-procedural data and follow-up data were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 155 patients from 22 centres of nine European countries were treated by concomitant pentaspline catheter PFA-based PVI and LAAC. The mean CHA2DS2-VA score was 3.1 \u00b1 1.4. The primary efficacy endpoint was achieved at 97.4% with successful PVI at 100% and successful LAAC in 151\/155 patients (97.4%). The primary safety endpoint was observed in 3\/155 patients (1.9%). Transoesophageal echocardiography and\/or CCTA 67 \u00b1 26 days after the procedure showed no device embolization and no device-related thrombus, 24\/151 (15.9%) patients showed peri-device gaps of &amp;lt;5\u2005mm while gaps of &amp;gt;5\u2005mm have been observed in 3\/151 (2.0%). Among 137\/155 patients with available arrhythmia, a follow-up &amp;gt;6 months at 78.1% showed sinus rhythm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large multicentre study, concomitant PFA-based AF ablation and LAA closure proved to be feasible, effective, and safe and overall procedure duration was short.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euag198","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:52:34Z","timestamp":1785498754000},"source":"Crossref","is-referenced-by-count":0,"title":["COnCOmitaNt pulsed field ablation-based pUlmonary vein isolation and lefT atrial appendage closure: the COCONUT study"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-8097","authenticated-orcid":false,"given":"Christian-Hendrik","family":"Heeger","sequence":"first","affiliation":[{"name":"Department of Cardiology, Asklepios Klinik Hamburg Altona , Germany, Paul Ehrlich Stra\u00dfe 1, 22763 Hamburg ,","place":["Germany"]},{"name":"Department of Rhythmology, University Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein , Ratzeburger Allee 160, L\u00fcbeck, Germany"},{"name":"German Center for Cardiovascular Research, Partner Site Hamburg\/Kiel\/Luebeck , Potsdamer Str. 58, 10785 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-1329","authenticated-orcid":false,"given":"Laurent","family":"Roten","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern , Bern 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