{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:16:54Z","timestamp":1788009414468,"version":"build-2784847793"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Pulsed field (PF) ablation is increasingly used to treat paroxysmal atrial fibrillation (PAF). FlexPulse (NCT06676072) was conducted to evaluate safety and effectiveness of a novel dual-energy, flexible-tip focal ablation catheter with radiofrequency and PF for treatment of symptomatic, drug-refractory PAF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>FlexPulse was a global, prospective, single arm, multicentre study. The ablation procedures targeted pulmonary vein isolation (PVI) and adjunctive ablation at operators\u2019 discretion. The primary safety endpoint was occurrence of pre-defined safety events within 7-days of any ablation procedure. The primary effectiveness endpoint was freedom from a composite of recurrent AF\/atrial tachycardia\/atrial flutter, repeat procedure, new use or escalation of class I\/III AAD, and\/or cardioversion through 12-months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 180 subjects underwent PAF ablation. Successful PVI was achieved in all participants. Additional non-PV ablations were performed in 37.2% (67\/180) of subjects. The primary safety endpoint event rate was 1.7%. The primary effectiveness endpoint was 74.6% at 12-months, and freedom from documented AF\/AFL\/AT recurrence was 77.4% (92.6% without weekly transtelephonic monitoring). In 15 subjects who underwent repeat ablation after the blanking period, remapping indicated that 79.7% (47\/59) of the PVs were durably isolated from the index procedures. Retrospective analysis found that workflows with PFA Index (PI) \u226530 and AutoMark distance up to 6 mm target had a 12-month freedom from AF\/AFL\/AT of 84.6%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this trial, ablation with TactiFlex Duo in patients with symptomatic, drug-refractory PAF was safe and effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euag238","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:02:09Z","timestamp":1788008529000},"source":"Crossref","is-referenced-by-count":0,"title":["Safety and Effectiveness of a Novel Dual-Energy Radiofrequency\/Pulsed Field Ablation Catheter: 12 Month Results of the FlexPulse Study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-1525","authenticated-orcid":false,"given":"Ayman A","family":"Hussein","sequence":"first","affiliation":[{"name":"Cleveland Clinic , Cleveland, Ohio ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3272-4380","authenticated-orcid":false,"given":"Gediminas","family":"Rackauskas","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine, Vilnius University , Vilnius ,","place":["Lithuania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-9745","authenticated-orcid":false,"given":"Sri","family":"Sundaram","sequence":"additional","affiliation":[{"name":"South Denver Cardiology , Denver, Colorado ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-2404","authenticated-orcid":false,"given":"Jonathan P","family":"Piccini","sequence":"additional","affiliation":[{"name":"Duke University , Durham, North Carolina ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz Xaver","family":"Roithinger","sequence":"additional","affiliation":[{"name":"NO Landesgesundheitsagentur, Il. Internal Medicine Department , Wiener Neustadt ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Tung","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center , Boston, Massachusetts ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7466-123X","authenticated-orcid":false,"given":"Jose","family":"Osorio","sequence":"additional","affiliation":[{"name":"HCA Florida , Miami, Florida ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"B Judson","family":"Colley","sequence":"additional","affiliation":[{"name":"The Heart Rhythm Center of Mississippi , Gulfport, Mississippi ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman R","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Advent Health Orlando , Orlando, Florida ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1492-2693","authenticated-orcid":false,"given":"Dhanunjaya R","family":"Lakkireddy","sequence":"additional","affiliation":[{"name":"Kansas City Heart Rhythm Institute , Overland Park, Kansas ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry A","family":"Chinitz","sequence":"additional","affiliation":[{"name":"NYU Langone Health , New York, New York ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4050-6925","authenticated-orcid":false,"given":"Matthew C","family":"Hyman","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1359-9916","authenticated-orcid":false,"given":"Laura","family":"Zitella Verbick","sequence":"additional","affiliation":[{"name":"Abbott , Plymouth, Minnesota ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-6715","authenticated-orcid":false,"given":"Nick","family":"Dirckx","sequence":"additional","affiliation":[{"name":"Abbott , Plymouth, Minnesota ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-8396","authenticated-orcid":false,"given":"Virginia","family":"Woods","sequence":"additional","affiliation":[{"name":"Abbott , Plymouth, Minnesota ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-9010","authenticated-orcid":false,"given":"Monica","family":"Lo","sequence":"additional","affiliation":[{"name":"CardioVascular Health Clinic , Oklahoma City, Oklahoma ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,29]]},"container-title":["Europace"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/europace\/advance-article-pdf\/doi\/10.1093\/europace\/euag238\/70828206\/euag238.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/europace\/advance-article-pdf\/doi\/10.1093\/europace\/euag238\/70828206\/euag238.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:02:09Z","timestamp":1788008529000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/advance-article\/doi\/10.1093\/europace\/euag238\/8772350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/europace\/euag238","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,29]]},"article-number":"euag238"}}