{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:02:43Z","timestamp":1789696963006,"version":"4.0.1"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012651","name":"Montreal Heart Institute Foundation","doi-asserted-by":"publisher","award":["4800"],"award-info":[{"award-number":["4800"]}],"id":[{"id":"10.13039\/501100012651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012651","name":"Montreal Heart Institute Foundation","doi-asserted-by":"publisher","award":["4805"],"award-info":[{"award-number":["4805"]}],"id":[{"id":"10.13039\/501100012651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013228","name":"Quebec Network for Research in Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013228","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020951","name":"Fonds de recherche du Qu\u00e9bec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020951","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001805","name":"Canadian Foundation for Innovation","doi-asserted-by":"publisher","award":["42228"],"award-info":[{"award-number":["42228"]}],"id":[{"id":"10.13039\/501100001805","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FRQ Early-career establishment","award":["376546"],"award-info":[{"award-number":["376546"]}]},{"name":"FRQ Early-career establishment","award":["368815"],"award-info":[{"award-number":["368815"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is the most frequently diagnosed cardiac arrhythmia. Catheter ablation using radiofrequency cauterization (CA-RFC) performed in the left atrium (LA) aims to isolate electrical sources of AF. This intervention is accompanied by frequent AF recurrences affecting 10% of patients at 30 days and 50% at one-year post-procedure. It has been suggested that inflammation could contribute to AF-recurrence post-CA-RFC. Given its anti-inflammatory and cardioprotective properties, colchicine has been proposed as a potential treatment to prevent AF recurrence post-CA-RFC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>RFC can lead to atrial fibrosis, inflammation, and new-onset AF, which may be mitigated by colchicine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Male and female Wistar rats (225\u2013275\u2005g) were divided into four groups: Sham or RFC, with or without colchicine (0.25\u2005mg\/kg\/8\u2005h, intraperitoneally) starting 8\u2005h before surgery until D1 post-procedure. Sham animals underwent surgery without RFC. Electrophysiology and echocardiography assessments were performed on days 1 (D1) and 3 (D3) post-RFC. Colchicine significantly lowered RFC-induced AF vulnerability, improved LA conduction velocity, reduced LA fibrosis, and attenuated LA inflammation post-procedure. Colchicine also prevented RFC-induced CD11c+ macrophages while promoting CD206+ recruitment in the LA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Colchicine started before RFC may be an innovative strategy to prevent the development of LA arrhythmogenic substrate post-procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euag242","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:27:39Z","timestamp":1788521259000},"source":"Crossref","is-referenced-by-count":0,"title":["Colchicine initiated before radiofrequency-induced injury attenuates left atrial inflammation, fibrosis, and susceptibility to atrial fibrillation"],"prefix":"10.1093","volume":"28","author":[{"given":"Abir","family":"Attia","sequence":"first","affiliation":[{"name":"Montreal Heart Institute, Faculty of Medicine , 5000 Belanger Street Montreal 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H1T 1C8","place":["Canada"]},{"name":"Department of Pharmacology and Physiology, Universit\u00e9 de Montreal , Montreal ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1057-0528","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"Tanguay","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Faculty of Medicine , 5000 Belanger Street Montreal , , Montreal , H1T 1C8","place":["Canada"]},{"name":"Universit\u00e9 de Montreal , 5000 Belanger Street Montreal , , Montreal , H1T 1C8","place":["Canada"]},{"name":"Department of Medicine, Faculty of Medicine, Universit\u00e9 de Montreal , Montreal ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-8983","authenticated-orcid":false,"given":"Jean-Claude","family":"Tardif","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute, Faculty of Medicine , 5000 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