{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:04:28Z","timestamp":1790078668936,"version":"4.0.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011727","name":"Stockholm County Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["DNR 2022-01466"],"award-info":[{"award-number":["DNR 2022-01466"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018713","name":"CIMED","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Atrial fibrillation is associated with increased risks of stroke, heart failure, and death. While stroke prevention is a key focus, heart failure is more frequent and a major contributor to mortality in atrial fibrillation. This study aimed to assess the incidence and timing of heart failure in screening-detected atrial fibrillation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This post hoc analysis included participants without prior heart failure from the STROKESTOP and STROKESTOP II randomized screening studies, in which individuals aged 75\u201376 years were invited to ECG-based atrial fibrillation screening. Incident heart failure diagnoses were obtained from national registries. Incidence rates were calculated per 100 person-years, and Cox regression was used to estimate hazard ratios (HRs). In STROKESTOP, 23% of participants with screening-detected atrial fibrillation developed heart failure (3.76 per 100 person-years), compared with 4.43 in patients with known atrial fibrillation and 1.08 in patients without atrial fibrillation. Screening-detected atrial fibrillation was associated with a three-fold higher heart failure risk vs. no atrial fibrillation (adjusted HR 3.19) and a risk comparable to known atrial fibrillation (adjusted HR 2.86). In STROKESTOP II, 20% developed heart failure (4.19 per 100 person-years), compared with 3.52 in known atrial fibrillation and 0.93 without atrial fibrillation. Screening-detected atrial fibrillation was associated with a four-fold higher heart failure risk vs. no atrial fibrillation (adjusted HR 4.73) and a higher risk than known atrial fibrillation (adjusted HR 2.59).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Screening-detected atrial fibrillation is associated with a high risk of heart failure, comparable to known atrial fibrillation, and is not a benign condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euag250","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T19:57:51Z","timestamp":1788465471000},"source":"Crossref","is-referenced-by-count":0,"title":["Incident heart failure in patients with screening-detected atrial fibrillation: a\n                    <i>post hoc<\/i>\n                    analysis of the STROKESTOP and STROKESTOP II studies"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6012-8430","authenticated-orcid":false,"given":"Gina","family":"Sado","sequence":"first","affiliation":[{"name":"Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge , SE-141 83 Huddinge ,","place":["Sweden"]},{"name":"Department of Cardiology, Danderyd University Hospital , SE-182 88 Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1189-9950","authenticated-orcid":false,"given":"Carl","family":"Bonander","sequence":"additional","affiliation":[{"name":"School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Box 453, SE-405 30 Gothenburg ,","place":["Sweden"]},{"name":"Karlstad Business School, Karlstad University , SE-651 88 Karlstad ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5106-749X","authenticated-orcid":false,"given":"Katrin","family":"Kemp Gudmundsdottir","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet , SE-182 88 Stockholm ,","place":["Sweden"]},{"name":"Division of Cardiac, Oncology and Ophthalmic Diseases, Department of Cardiology, Landspitali University Hospital , Hringbraut, 101 Reykjavik ,","place":["Iceland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Djupsj\u00f6","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge , SE-141 83 Huddinge ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0376-8133","authenticated-orcid":false,"given":"Viveka","family":"Frykman 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