{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:03:23Z","timestamp":1789747403166,"version":"4.0.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgrounds and Aims<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) screening may reduce adverse outcomes through early initiation of preventive treatment. However, more data are warranted to inform the yield of different screening strategies. This study aimed to evaluate how patient characteristics and screening methodologies influence screening yield.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted an individual participant data meta-analysis of 12 European and North American study cohorts, by using generalized linear mixed models with random intercept at study level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this meta-analysis of 34,165 participants screened for AF (age 73.4\u2009\u00b1\u20097.5 years and 53.5% female), the screening yield increased with more intensive approaches, ranging from 0.83% [95% confidence interval (CI): 0.24-2.87] in single-timepoint screening, to 5.06% [95% CI: 3.55-7.17] in intermittent (i.e. repeated single-timepoint) screening, 4.81% [95% CI: 3.79-6.08] in short-term continuous monitoring (\u226430 days), and up to 30.39% [95% CI: 28.06-32.84] in long-term continuous monitoring (&amp;gt;30 days). Advanced age, male sex, hypertension, and heart failure (HF) were associated with detection. Significant interactions were observed between screening approach and age, sex, HF, CHADS2, and NT-proBNP. These risk factors had a stronger influence on AF detection with single-timepoint screening, compared with more intensive methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this meta-analysis, AF screening yield varied substantially by patient characteristics and screening approach. Advanced age, male sex, and HF were independently associated with greater AF detection, particularly in those having single-timepoint screening. Our findings support tailoring the screening approach to the individual target population in clinical practice. Further studies to assess clinical outcomes following screening are needed and underway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euag256","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:18:51Z","timestamp":1789672731000},"source":"Crossref","is-referenced-by-count":0,"title":["Yield of Atrial Fibrillation Screening according to Methodology and Patient Characteristics:\n                    <i>An Individual Participant Data Meta-Analysis of 34,165 Individuals Screened for Atrial Fibrillation within the AFFECT-EU\/AF-SCREEN Collaboration<\/i>"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-3125","authenticated-orcid":false,"given":"Lucas Y","family":"Xing","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Rigshospitalet , Copenhagen ,","place":["Denmark"]},{"name":"Department of Internal Medicine, Zealand University Hospital \u2013 Nyk\u00f8bing F. , Nyk\u00f8bing Falster ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6082-7542","authenticated-orcid":false,"given":"William F","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University , Hamilton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1677-7215","authenticated-orcid":false,"given":"Johan","family":"Engdahl","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Clinical Sciences, Danderyds University Hospital , Stockholm ,","place":["Sweden"]},{"name":"Department of Cardiology, Danderyds University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3889-5386","authenticated-orcid":false,"given":"Matthias Daniel","family":"Zink","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pneumology, Angiology, Acute Geriatrics, Intensive Care Medicine & Thoracic Surgery, Ortenau Klinikum , Lahr ,","place":["Germany"]},{"name":"Department of Internal Medicine I, University Hospital Aachen , Aachen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6141-634X","authenticated-orcid":false,"given":"Nikolaus Albert Helmut","family":"Marx","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Aachen , Aachen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-0870","authenticated-orcid":false,"given":"Emma","family":"Svennberg","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Medicine Huddinge, Karolinska University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5106-749X","authenticated-orcid":false,"given":"Katrin Kemp","family":"Gudmundsdottir","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Department of Clinical Sciences, Division of Cardiovascular Medicine, Danderyd University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0430-1583","authenticated-orcid":false,"given":"Jelle C L","family":"Himmelreich","sequence":"additional","affiliation":[{"name":"Department of General Practice, Amsterdam UMC , Amsterdam ,","place":["Netherlands"]},{"name":"Amsterdam Public Health , Amsterdam ,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-4815","authenticated-orcid":false,"given":"Giuseppe","family":"Boriani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Modena University Hospital , Modena ,","place":["Italy"]},{"name":"Department of Biomedical Metabolic and Neural Sciences, University of Modena and Reggio Emilia , Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6345-3742","authenticated-orcid":false,"given":"Davide Antonio","family":"Mei","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Modena University Hospital , Modena ,","place":["Italy"]},{"name":"Department of Biomedical Metabolic and Neural Sciences, University of Modena and Reggio Emilia , Modena ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-6258","authenticated-orcid":false,"given":"Daniel","family":"Engler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) partner site Hamburg\/Kiel\/L\u00fcbeck , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9256-7914","authenticated-orcid":false,"given":"Steven R","family":"Steinhubl","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering, Purdue University , West Lafayette ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6389-5054","authenticated-orcid":false,"given":"Karl Georg","family":"Haeusler","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital and University of Ulm , Ulm ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6520-3720","authenticated-orcid":false,"given":"Matthias","family":"Endres","sequence":"additional","affiliation":[{"name":"Klinik und Hochschulambulanz f\u00fcr Neurologie, Charit\u00e9-Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"Center for Stroke Research Berlin, Charit\u00e9-Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]},{"name":"German Center for Neurodegenerative Diseases (DZNE), German Centre for Cardiovascular Research (DZHK), German Center for Mental Health (DZPG) \u2013 partner sites Berlin , Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-2279","authenticated-orcid":false,"given":"Joan","family":"Montaner","sequence":"additional","affiliation":[{"name":"Institute de Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/University of Seville , Seville ,","place":["Spain"]},{"name":"Department of Neurology, Hospital Universitario Virgen Macarena , Seville ,","place":["Spain"]},{"name":"Neurovascular Research Laboratory, Vall d\u2019Hebron Institute of Research (VHIR), Hospital Vall d\u2019Hebron , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3809-2911","authenticated-orcid":false,"given":"Ben","family":"Freedman","sequence":"additional","affiliation":[{"name":"Heart Research Institute, The University of Sydney , Sydney ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7170-9509","authenticated-orcid":false,"given":"Renate B","family":"Schnabel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) partner site Hamburg\/Kiel\/L\u00fcbeck , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1216-7580","authenticated-orcid":false,"given":"Jeff S","family":"Healey","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University , Hamilton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-8515","authenticated-orcid":false,"given":"Jesper Hastrup","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Rigshospitalet , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9687-0857","authenticated-orcid":false,"given":"S\u00f8ren Z\u00f6ga","family":"Diederichsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Rigshospitalet , Copenhagen 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