{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:24:42Z","timestamp":1768310682594,"version":"3.49.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1093\/europace\/eut012","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T12:46:06Z","timestamp":1361277966000},"page":"754-760","source":"Crossref","is-referenced-by-count":40,"title":["Role of nitric oxide and oxidative stress in a sheep model of persistent atrial fibrillation"],"prefix":"10.1093","volume":"15","author":[{"given":"Ilse","family":"Lenaerts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald B.","family":"Driesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerea Hermida","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Holemans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hein","family":"Heidb\u00fcchel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Janssens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Luc","family":"Balligand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin R.","family":"Sipido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rik","family":"Willems","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,2,17]]},"reference":[{"key":"key\n\t\t\t\t20170624064137_EUT012C1","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1161\/01.CIR.0000140263.20897.42","article-title":"Lifetime risk for development of atrial fibrillation: the Framingham Heart Study","volume":"110","author":"Lloyd-Jones","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624064137_EUT012C2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijcard.2006.04.026","article-title":"The role of oxidative stress in the pathogenesis and perpetuation of atrial fibrillation","volume":"115","author":"Korantzopoulos","year":"2007","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20170624064137_EUT012C3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ijcard.2009.04.043","article-title":"Use of vitamins C and E as a prophylactic therapy to prevent postoperative atrial fibrillation","volume":"138","author":"Rodrigo","year":"2010","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20170624064137_EUT012C4","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1161\/01.CIR.104.2.174","article-title":"Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation","volume":"104","author":"Mihm","year":"2001","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624064137_EUT012C5","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1161\/hh1801.097644","article-title":"Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation","volume":"89","author":"Carnes","year":"2001","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170624064137_EUT012C6","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1161\/01.CIR.0000145163.56529.D1","article-title":"Effect of simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrial-tachycardia remodeling in dogs","volume":"110","author":"Shiroshita-Takeshita","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624064137_EUT012C7","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1161\/01.CIR.0000039327.11661.16","article-title":"Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke","volume":"106","author":"Cai","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624064137_EUT012C8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ijcard.2010.09.004","article-title":"The impact of rapid atrial pacing on ADMA and endothelial NOS","volume":"154","author":"Goette","year":"2010","journal-title":"Int J Cardiol"},{"key":"key\n\t\t\t\t20170624064137_EUT012C9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.cardiores.2005.11.028","article-title":"Prednisone prevents atrial fibrillation promotion by atrial tachycardia remodeling in dogs","volume":"69","author":"Shiroshita-Takeshita","year":"2006","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170624064137_EUT012C10","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.carpath.2008.12.014","article-title":"Atrial expression of endothelial nitric oxide synthase in patients with and without atrial fibrillation","volume":"19","author":"Bukowska","year":"2010","journal-title":"Cardiovasc Pathol"},{"key":"key\n\t\t\t\t20170624064137_EUT012C11","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/CIRCULATIONAHA.111.029223","article-title":"Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins","volume":"124","author":"Reilly","year":"2011","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624064137_EUT012C12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1020841906241","article-title":"Plasma levels of nitrites\/nitrates in patients with chronic atrial fibrillation are increased after electrical restoration of sinus rhythm","volume":"7","author":"Nikitovic","year":"2002","journal-title":"J Interv Card Electrophysiol"},{"key":"key\n\t\t\t\t20170624064137_EUT012C13","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1161\/01.ATV.17.11.3191","article-title":"Plasma levels of nitrite\/nitrate and platelet CGMP levels are decreased in patients with atrial fibrillation","volume":"17","author":"Minamino","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20170624064137_EUT012C14","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1093\/nar\/gng073","article-title":"Experimental validation of novel and conventional approaches to quantitative real-time pcr data analysis","volume":"31","author":"Peirson","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170624064137_EUT012C15","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1006\/meth.2001.1261","article-title":"An overview of real-time quantitative PCR: applications to quantify cytokine gene expression","volume":"25","author":"Giulietti","year":"2001","journal-title":"Methods"},{"key":"key\n\t\t\t\t20170624064137_EUT012C16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.HYP.0000032031.30374.32","article-title":"Activation of NADPH oxidase during progression of cardiac hypertrophy to failure","volume":"40","author":"Li","year":"2002","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170624064137_EUT012C17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1161\/01.RES.0000183735.09871.61","article-title":"A myocardial NOX2 containing NAD(P)H oxidase contributes to oxidative stress in human atrial fibrillation","volume":"97","author":"Kim","year":"2005","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170624064137_EUT012C18","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/CIRCULATIONAHA.105.538108","article-title":"Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases","volume":"112","author":"Dudley","year":"2005","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624064137_EUT012C19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.yjmcc.2009.04.004","article-title":"Nadph oxidase signaling and cardiac myocyte function","volume":"47","author":"Akki","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170624064137_EUT012C20","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1161\/01.CIR.0000091084.46500.BB","article-title":"Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-gtpase and represents a target for statin treatment","volume":"108","author":"Maack","year":"2003","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20170624064137_EUT012C21","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1046\/j.1540-8167.2001.01387.x","article-title":"Different patterns of angiotensin II and atrial natriuretic peptide secretion in a sheep model of atrial fibrillation","volume":"12","author":"Willems","year":"2001","journal-title":"J Cardiovasc Electrophysiol"},{"key":"key\n\t\t\t\t20170624064137_EUT012C22","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yjmcc.2007.05.010","article-title":"Self-terminating AF depends on electrical remodeling while persistent AF depends on additional structural changes in a rapid atrially paced sheep model","volume":"43","author":"Anne","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"key\n\t\t\t\t20170624064137_EUT012C23","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1136\/hrt.2003.023069","article-title":"Atrial fibrillation after radiofrequency ablation of atrial flutter: preventive effect of angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, and diuretics","volume":"90","author":"Anne","year":"2004","journal-title":"Heart"},{"key":"key\n\t\t\t\t20170624064137_EUT012C24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/1071576021000040655","article-title":"The role of tetrahydrobiopterin in superoxide generation from enos: enzymology and physiological implications","volume":"37","author":"Vasquez-Vivar","year":"2003","journal-title":"Free Radic Res"},{"key":"key\n\t\t\t\t20170624064137_EUT012C25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/cvr\/cvr087","article-title":"Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology","volume":"91","author":"Nishijima","year":"2011","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t20170624064137_EUT012C26","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/01.RES.79.3.363","article-title":"Nitric oxide and cardiac function","volume":"79","author":"Kelly","year":"1996","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170624064137_EUT012C27","doi-asserted-by":"crossref","first-page":"14692","DOI":"10.1074\/jbc.274.21.14692","article-title":"Autoinhibition of endothelial nitric-oxide synthase","volume":"274","author":"Nishida","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170624064137_EUT012C28","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1161\/CIRCRESAHA.109.206276","article-title":"Ultrastructural and functional remodeling of the coupling between Ca2+ influx and sarcoplasmic reticulum Ca2+ release in right atrial myocytes from experimental persistent atrial fibrillation","volume":"105","author":"Lenaerts","year":"2009","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170624064137_EUT012C29","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/01.RES.0000126497.38281.23","article-title":"Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction","volume":"94","author":"Janssens","year":"2004","journal-title":"Circ Res"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/15\/5\/754\/17859335\/eut012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T05:00:37Z","timestamp":1503464437000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article-lookup\/doi\/10.1093\/europace\/eut012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,17]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,2,17]]},"published-print":{"date-parts":[[2013,5]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/eut012","relation":{},"ISSN":["1532-2092","1099-5129"],"issn-type":[{"value":"1532-2092","type":"electronic"},{"value":"1099-5129","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2,17]]}}}