{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:09:40Z","timestamp":1784077780840,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"suppl_4","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL96544 (to A.D.M.), 1R01HL105242 (to A.D.M.), 1R01HL121754 (to A.D.M.), 8P41GM103426 (to R. Amaro and A.D.M.) and P50GM094503"],"award-info":[{"award-number":["1R01HL96544 (to A.D.M.), 1R01HL105242 (to A.D.M.), 1R01HL121754 (to A.D.M.), 8P41GM103426 (to R. Amaro and A.D.M.) and P50GM094503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,1]]},"DOI":"10.1093\/europace\/euw356","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T16:05:13Z","timestamp":1477929913000},"page":"iv104-iv112","source":"Crossref","is-referenced-by-count":26,"title":["Non-invasive, model-based measures of ventricular electrical dyssynchrony for predicting CRT outcomes"],"prefix":"10.1093","volume":"18","author":[{"given":"Christopher T.","family":"Villongco","sequence":"first","affiliation":[{"name":"Department of Bioengineering, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0412, USA"},{"name":"Department of Medicine (Cardiology), University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0613, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Krummen","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology), University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0613, USA"},{"name":"US Department of Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Omens","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0412, USA"},{"name":"Department of Medicine (Cardiology), University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0613, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"McCulloch","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0412, USA"},{"name":"Department of Medicine (Cardiology), University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0613, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"issue":"259","key":"key\n\t\t\t\t20180222001227_euw356-B1","doi-asserted-by":"crossref","first-page":"H300","DOI":"10.1152\/ajpheart.1990.259.2.H300","article-title":"Redistribution of myocardial fiber strain and blood flow by asynchronous activation","volume":"1","author":"Prinzen","year":"1990","journal-title":"Am J Physiol-Heart Circ Physiol"},{"issue":"167","key":"key\n\t\t\t\t20180222001227_euw356-B2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ahj.2013.10.017","article-title":"Absolute survival after cardiac resynchronization therapy according to baseline QRS duration: a multinational 10-year experience: data from the Multicenter International CRT Study","volume":"28","author":"Gasparini","year":"2014","journal-title":"Am Heart J"},{"key":"key\n\t\t\t\t20180222001227_euw356-B3","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1161\/CIRCULATIONAHA.110.955039","article-title":"Effect of cardiac resynchronization therapy on reverse remodeling and correlation to outcome multicenter automatic defibrillator implantation trial: cardiac resynchronization therapy","volume":"122","author":"Solomon","year":"2010","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180222001227_euw356-B4","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/CIRCULATIONAHA.105.538272","article-title":"Left ventricular reverse remodeling but not clinical improvement predicts long-term survival after cardiac resynchronization therapy","volume":"112","author":"Yu","year":"2005","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180222001227_euw356-B5","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1161\/01.CIR.99.12.1567","article-title":"Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay","volume":"99","author":"Kass","year":"1999","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180222001227_euw356-B6","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1161\/01.CIR.0000035037.11968.5C","article-title":"Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block","volume":"106","author":"Leclercq","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180222001227_euw356-B7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/heart.89.1.54","article-title":"High prevalence of left ventricular systolic and diastolic asynchrony in patients with congestive heart failure and normal QRS duration","volume":"89","author":"Yu","year":"2003","journal-title":"Heart"},{"key":"key\n\t\t\t\t20180222001227_euw356-B8","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1306687","article-title":"Cardiac-resynchronization therapy in heart failure with a narrow QRS complex","volume":"369","author":"Ruschitzka","year":"2013","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180222001227_euw356-B9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1046\/j.1540-8167.2005.40777.x","article-title":"Right and left ventricular activation sequence in patients with heart failure and right bundle branch block: a detailed analysis using three\u2010dimensional non\u2010fluoroscopic electroanatomic mapping system","volume":"16","author":"Fantoni","year":"2005","journal-title":"J Cardiovasc Electrophysiol"},{"key":"key\n\t\t\t\t20180222001227_euw356-B10","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1161\/01.CIR.0000118502.91105.F6","article-title":"Characterization of left ventricular activation in patients with heart failure and left bundle-branch block","volume":"109","author":"Auricchio","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180222001227_euw356-B11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1540-8167.2003.02421.x","article-title":"Variable patterns of septal activation in patients with left bundle branch block and heart failure","volume":"14","author":"Rodriguez","year":"2003","journal-title":"J Cardiovasc Electrophysiol"},{"key":"key\n\t\t\t\t20180222001227_euw356-B12","first-page":"682","article-title":"Transseptal conduction as an important determinant for cardiac resynchronization therapy, as revealed by extensive electrical mapping in the dyssynchronous canine heart","volume":"6","author":"Strik","year":"2013","journal-title":"Circulation: Arrhythm Electrophysiol"},{"key":"key\n\t\t\t\t20180222001227_euw356-B13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/europace\/euu221","article-title":"Left ventricular lead placement in the latest activated region guided by coronary venous electroanatomic mapping","volume":"17","author":"Rad","year":"2015","journal-title":"Europace"},{"key":"key\n\t\t\t\t20180222001227_euw356-B14","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1093\/europace\/eus170","article-title":"Cardiac resynchronization therapy beyond nominal settings: who needs individual programming of the atrioventricular and interventricular delay?","volume":"14","author":"Bogaard","year":"2012","journal-title":"Europace"},{"key":"key\n\t\t\t\t20180222001227_euw356-B15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.pbiomolbio.2014.06.011","article-title":"Patient-specific modeling of ventricular activation pattern using surface ECG-derived vectorcardiogram in bundle branch block","volume":"115","author":"Villongco","year":"2014","journal-title":"Prog Biophys Mol Biol"},{"key":"key\n\t\t\t\t20180222001227_euw356-B16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.pbiomolbio.2011.06.014","article-title":"Patient-specific modeling of dyssynchronous heart failure: a case study","volume":"107","author":"Aguado-Sierra","year":"2011","journal-title":"Prog Biophys Mol Biol"},{"key":"key\n\t\t\t\t20180222001227_euw356-B17","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/oxfordjournals.eurheartj.a059647","article-title":"Reconstruction of the Frank vectorcardiogram from standard electrocardiographic leads: diagnostic comparison of different methods","volume":"11","author":"Kors","year":"1990","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180222001227_euw356-B18","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/01.CIR.98.9.887","article-title":"Simultaneous endocardial mapping in the human left ventricle using a noncontact catheter comparison of contact and reconstructed electrograms during sinus rhythm","volume":"98","author":"Schilling","year":"1998","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180222001227_euw356-B19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/europace\/eup337","article-title":"A prospective comparison of echocardiography and device algorithms for atrioventricular and interventricular interval optimization in cardiac resynchronization therapy","volume":"12","author":"Kamdar","year":"2010","journal-title":"Europace"},{"key":"key\n\t\t\t\t20180222001227_euw356-B20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jcp.2012.09.015","article-title":"Patient-specific models of cardiac biomechanics","volume":"244","author":"Krishnamurthy","year":"2013","journal-title":"J Comput Phys"},{"key":"key\n\t\t\t\t20180222001227_euw356-B21","doi-asserted-by":"crossref","first-page":"H1365","DOI":"10.1152\/ajpheart.1991.260.4.H1365","article-title":"Mathematical model of geometry and fibrous structure of the heart","volume":"260","author":"Nielsen","year":"1991","journal-title":"Am J Physiol-Heart Circ Physiol"},{"key":"key\n\t\t\t\t20180222001227_euw356-B22","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.media.2013.03.005","article-title":"A three-dimensional finite element model of human atrial anatomy: new methods for cubic Hermite meshes with extraordinary vertices","volume":"17","author":"Gonzales","year":"2013","journal-title":"Med Image Anal"},{"issue":"2","key":"key\n\t\t\t\t20180222001227_euw356-B23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/mrm.20965","article-title":"Log\u2010Euclidean metrics for fast and simple calculus on diffusion tensors","volume":"56","author":"Arsigny","year":"2006","journal-title":"Magn Reson Med"},{"issue":"3","key":"key\n\t\t\t\t20180222001227_euw356-B24","doi-asserted-by":"crossref","first-page":"H1088","DOI":"10.1152\/ajpheart.00109.2006","article-title":"Alternans and spiral breakup in a human ventricular tissue model","volume":"291","author":"ten Tusscher","year":"2006","journal-title":"Am J Physiol-Heart Circ Physiol"},{"key":"key\n\t\t\t\t20180222001227_euw356-B25","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.RES.82.11.1206","article-title":"Simulation study of cellular electric properties in heart failure","volume":"82","author":"Priebe","year":"1998","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20180222001227_euw356-B26","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1136\/hrt.2003.024273","article-title":"Beyond the measurement of QRS complex toward mechanical dyssynchrony: cardiac resynchronisation therapy in heart failure patients with a normal QRS duration","volume":"90","author":"Auricchio","year":"2004","journal-title":"Heart"},{"key":"key\n\t\t\t\t20180222001227_euw356-B27","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.jacc.2013.08.715","article-title":"Comparative electromechanical and hemodynamic effects of left ventricular and biventricular pacing in dyssynchronous heart failure: electrical resynchronization versus left\u2013right ventricular interaction","volume":"62","author":"Lumens","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"key\n\t\t\t\t20180222001227_euw356-B28","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.hrthm.2014.12.031","article-title":"Electrical dyssynchrony induced by biventricular pacing: implications for patient selection and therapy improvement","volume":"12","author":"Ploux","year":"2015","journal-title":"Heart Rhythm"},{"key":"key\n\t\t\t\t20180222001227_euw356-B29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.hrthm.2014.11.014","article-title":"The effect of reverse remodeling on long-term survival in mildly symptomatic patients with heart failure receiving cardiac resynchronization therapy: results of the REVERSE study","volume":"12","author":"Gold","year":"2015","journal-title":"Heart Rhythm"},{"key":"key\n\t\t\t\t20180222001227_euw356-B30","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/eurjhf\/hfr094","article-title":"Baseline left ventricular dP\/dtmax rather than the acute improvement in dP\/dtmax predicts clinical outcome in patients with cardiac resynchronization therapy","volume":"13","author":"Bogaard","year":"2011","journal-title":"EurJ Heart Fail"},{"key":"key\n\t\t\t\t20180222001227_euw356-B31","doi-asserted-by":"crossref","first-page":"E18","DOI":"10.1002\/clc.20683","article-title":"Maximum derivative of left ventricular pressure predicts cardiac mortality after cardiac resynchronization therapy","volume":"33","author":"Suzuki","year":"2010","journal-title":"Clin Cardiol"},{"key":"key\n\t\t\t\t20180222001227_euw356-B32","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jelectrocard.2015.05.004","article-title":"An in-silico analysis of the effect of heart position and orientation on the ECG morphology and vectorcardiogram parameters in patients with heart failure and intraventricular conduction defects","volume":"48","author":"Nguy\u00ean","year":"2015","journal-title":"J Electrocardiol"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/18\/suppl_4\/iv104\/24119829\/euw356.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:12:41Z","timestamp":1519258361000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/18\/suppl_4\/iv104\/2737199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,1]]},"references-count":32,"journal-issue":{"issue":"suppl_4","published-online":{"date-parts":[[2016,12,23]]},"published-print":{"date-parts":[[2016,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euw356","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,12]]},"published":{"date-parts":[[2016,12,1]]}}}