{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:43:22Z","timestamp":1780998202213,"version":"3.54.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T00:00:00Z","timestamp":1547337600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministry of Science, Innovation and Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pro CNIC Foundation"},{"DOI":"10.13039\/501100005884","name":"CNIC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"BSC","doi-asserted-by":"publisher","award":["SEV-2015-0505"],"award-info":[{"award-number":["SEV-2015-0505"]}],"id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"BSC","doi-asserted-by":"publisher","award":["SEV-2011-0067"],"award-info":[{"award-number":["SEV-2011-0067"]}],"id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"publisher","award":["RD12\/0042\/0036"],"award-info":[{"award-number":["RD12\/0042\/0036"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"publisher","award":["CB16\/11\/00458"],"award-info":[{"award-number":["CB16\/11\/00458"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Science, Innovation and Universities","award":["SAF2016-80324-R"],"award-info":[{"award-number":["SAF2016-80324-R"]}]},{"name":"Spanish Ministry of Science, Innovation and Universities","award":["PI16\/02110"],"award-info":[{"award-number":["PI16\/02110"]}]},{"name":"Spanish Ministry of Science, Innovation and Universities","award":["DTS17\/00136"],"award-info":[{"award-number":["DTS17\/00136"]}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["AC16\/00021"],"award-info":[{"award-number":["AC16\/00021"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundaci\u00f3n Interhospitalaria para la Investigaci\u00f3n Cardiovascular"},{"DOI":"10.13039\/100000061","name":"FIC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009664","name":"Spanish Society of Cardiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009664","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heart Rhythm section of the Spanish Society of Cardiology"},{"name":"DFR","award":["HL122352"],"award-info":[{"award-number":["HL122352"]}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"USA National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CompBioMed project"},{"name":"European Union\u2019s Horizon 2020","award":["675451"],"award-info":[{"award-number":["675451"]}]},{"name":"\u2018la Caixa\u2019 Fellowship"},{"name":"\u2018la Caixa\u2019 Banking Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"DOI":"10.1093\/europace\/euy306","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T07:14:10Z","timestamp":1543821250000},"page":"822-832","source":"Crossref","is-referenced-by-count":19,"title":["Three-dimensional cardiac fibre disorganization as a novel parameter for ventricular arrhythmia stratification after myocardial infarction"],"prefix":"10.1093","volume":"21","author":[{"given":"Daniel G","family":"Le\u00f3n","sequence":"first","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Melchor Fern\u00e1ndez Almagro 3, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00f1a","family":"L\u00f3pez-Yunta","sequence":"additional","affiliation":[{"name":"Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Center (BSC), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Alfonso-Almaz\u00e1n","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Melchor Fern\u00e1ndez Almagro 3, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Marina-Breysse","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Melchor Fern\u00e1ndez Almagro 3, Madrid, Spain"},{"name":"Agencia Espa\u00f1ola de Protecci\u00f3n de la Salud en el Deporte (AEPSAD), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge G","family":"Quintanilla","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Melchor Fern\u00e1ndez Almagro 3, Madrid, Spain"},{"name":"Department of Cardiology, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Cardiovascular Institute, Madrid, Spain"},{"name":"CIBER de Enfermedades Cardiovasculares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Philips Healthcare Iberia, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gal\u00e1n-Arriola","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Melchor Fern\u00e1ndez Almagro 3, Madrid, Spain"},{"name":"CIBER de Enfermedades Cardiovasculares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Castro-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Melchor Fern\u00e1ndez Almagro 3, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Gonz\u00e1lez-Ferrer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Cardiovascular Institute, Madrid, Spain"},{"name":"CIBER de Enfermedades Cardiovasculares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Melchor Fern\u00e1ndez Almagro 3, Madrid, Spain"},{"name":"CIBER de Enfermedades Cardiovasculares, Madrid, Spain"},{"name":"IIS-University Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"P\u00e9rez-Villacast\u00edn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Cardiovascular Institute, Madrid, Spain"},{"name":"CIBER de Enfermedades Cardiovasculares, Madrid, Spain"},{"name":"Fundaci\u00f3n Interhospitalaria para la Investigaci\u00f3n Cardiovascular (FIC), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicasio","family":"P\u00e9rez-Castellano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Cardiovascular Institute, Madrid, Spain"},{"name":"CIBER de Enfermedades Cardiovasculares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valent\u00edn","family":"Fuster","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Melchor Fern\u00e1ndez Almagro 3, Madrid, Spain"},{"name":"The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Jalife","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Melchor Fern\u00e1ndez Almagro 3, Madrid, Spain"},{"name":"CIBER de Enfermedades Cardiovasculares, Madrid, Spain"},{"name":"Department of Internal Medicine, Center for Arrhythmia Research, Cardiovascular Research Center, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Center (BSC), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jazm\u00edn","family":"Aguado-Sierra","sequence":"additional","affiliation":[{"name":"Department of Computer Applications in Science and Engineering, Barcelona Supercomputing Center (BSC), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Filgueiras-Rama","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Myocardial Pathophysiology Area, Melchor Fern\u00e1ndez Almagro 3, Madrid, Spain"},{"name":"Department of Cardiology, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC), Cardiovascular Institute, Madrid, Spain"},{"name":"CIBER de Enfermedades Cardiovasculares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,12]]},"reference":[{"key":"2019042404532927100_euy306-B1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur Heart J"},{"key":"2019042404532927100_euy306-B2","first-page":"1601","article-title":"2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC)","volume":"17","author":"Priori","year":"2015","journal-title":"Europace"},{"key":"2019042404532927100_euy306-B3","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1172\/JCI115173","article-title":"Remodeling of ventricular conduction pathways in healed canine infarct border zones","volume":"87","author":"Luke","year":"1991","journal-title":"J Clin Invest"},{"key":"2019042404532927100_euy306-B4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.hrthm.2015.07.030","article-title":"A swine model of infarct-related reentrant ventricular tachycardia: electroanatomic, magnetic resonance, and histopathological characterization","volume":"13","author":"Tschabrunn","year":"2016","journal-title":"Heart Rhythm"},{"key":"2019042404532927100_euy306-B5","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jacc.2012.02.070","article-title":"Assessment of myocardial scarring improves risk stratification in patients evaluated for cardiac defibrillator implantation","volume":"60","author":"Klem","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2019042404532927100_euy306-B6","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1136\/heartjnl-2011-300060","article-title":"Scar size and characteristics assessed by CMR predict ventricular arrhythmias in ischaemic cardiomyopathy: comparison of previously validated models","volume":"97","author":"de Haan","year":"2011","journal-title":"Heart"},{"key":"2019042404532927100_euy306-B7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/europace\/eut289","article-title":"Scar extent as a predictive factor of ventricular tachycardia cycle length after myocardial infarction: implications for implantable cardioverter-defibrillator programming optimization","volume":"16","author":"Alexandre","year":"2014","journal-title":"Europace"},{"key":"2019042404532927100_euy306-B8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1161\/CIRCULATIONAHA.116.021955","article-title":"High-resolution mapping of postinfarction reentrant ventricular tachycardia: electrophysiological characterization of the circuit","volume":"134","author":"Anter","year":"2016","journal-title":"Circulation"},{"key":"2019042404532927100_euy306-B9","doi-asserted-by":"crossref","first-page":"pii:e007834","DOI":"10.1161\/JAHA.117.007834","article-title":"Myocardial scar delineation using diffusion tensor magnetic resonance tractography","volume":"7","author":"Mekkaoui","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2019042404532927100_euy306-B10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12968-016-0317-3","article-title":"Submillimeter diffusion tensor imaging and late gadolinium enhancement cardiovascular magnetic resonance of chronic myocardial infarction","volume":"19","author":"Pashakhanloo","year":"2017","journal-title":"J Cardiovasc Magn Reson"},{"key":"2019042404532927100_euy306-B11","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.jacc.2004.09.020","article-title":"Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model","volume":"44","author":"Amado","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2019042404532927100_euy306-B12","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.hrthm.2017.05.018","article-title":"Cardiac magnetic resonance-aided scar dechanneling: influence on acute and long-term outcomes","volume":"14","author":"Andreu","year":"2017","journal-title":"Heart Rhythm"},{"key":"2019042404532927100_euy306-B13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cmpb.2005.08.004","article-title":"DtiStudio: resource program for diffusion tensor computation and fiber bundle tracking","volume":"81","author":"Jiang","year":"2006","journal-title":"Comput Methods Programs Biomed"},{"key":"2019042404532927100_euy306-B14","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1161\/CIRCULATIONAHA.106.653568","article-title":"Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction","volume":"115","author":"Schmidt","year":"2007","journal-title":"Circulation"},{"key":"2019042404532927100_euy306-B15","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.jacc.2009.01.056","article-title":"Characterization of peri-infarct zone heterogeneity by contrast-enhanced multidetector computed tomography: a comparison with magnetic resonance imaging","volume":"53","author":"Schuleri","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2019042404532927100_euy306-B16","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/europace\/euq466","article-title":"The heart rate of ventricular tachycardia following an old myocardial infarction is inversely related to the size of scarring","volume":"13","author":"Woie","year":"2011","journal-title":"Europace"},{"key":"2019042404532927100_euy306-B17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jacep.2015.07.006","article-title":"Scar extension measured by magnetic resonance-based signal intensity mapping predicts ventricular tachycardia recurrence after substrate ablation in patients with previous myocardial infarction","volume":"1","author":"\u00c1vila","year":"2015","journal-title":"JACC Clin Electrophysiol"},{"key":"2019042404532927100_euy306-B18","doi-asserted-by":"crossref","first-page":"11437","DOI":"10.1038\/ncomms11437","article-title":"Arrhythmia risk stratification of patients after myocardial infarction using personalized heart models","volume":"7","author":"Arevalo","year":"2016","journal-title":"Nat Commun"},{"key":"2019042404532927100_euy306-B19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1152\/physrev.00025.2003","article-title":"Basic mechanisms of cardiac impulse propagation and associated arrhythmias","volume":"84","author":"Kleber","year":"2004","journal-title":"Physiol Rev"},{"key":"2019042404532927100_euy306-B20","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1161\/01.RES.63.1.182","article-title":"Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts","volume":"63","author":"Dillon","year":"1988","journal-title":"Circ Res"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/21\/5\/822\/28504620\/euy306.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T05:35:08Z","timestamp":1556084108000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/21\/5\/822\/5288690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,12]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,1,12]]},"published-print":{"date-parts":[[2019,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euy306","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,5]]},"published":{"date-parts":[[2019,1,12]]}}}