{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:50:54Z","timestamp":1785797454097,"version":"3.56.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Data on long-term follow-up of patients with Chagas\u2019 heart disease (ChHD) receiving a secondary prevention implantable cardioverter-defibrillator (ICD) are limited and its benefit is controversial. The aim of this study was to evaluate the long-term outcomes of ChHD patients who received a secondary prevention ICD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We assessed the outcomes of consecutive ChHD patients referred to our Institution from 2006 to 2014 for a secondary prevention ICD [89 patients; 58 men; mean age 56\u2009\u00b1\u200911\u2009years; left ventricular ejection fraction (LVEF), 42\u2009\u00b1\u200912%]. The primary outcome included a composite of death from any cause or heart transplantation. After a mean follow-up of 59\u2009\u00b1\u200927\u2009months, the primary outcome occurred in 23 patients (5.3% per year). Multivariate analysis showed that LVEF\u2009&lt;\u200935% [hazard ratio (HR) 4.64; P\u2009&lt;\u20090.01] and age\u2009\u2265\u200965\u2009years (HR 3.19; P\u2009&lt;\u20090.01) were independent predictors of the primary outcome. Using these two risk factors, a risk score was developed, and lower- (no risk factors), intermediate- (one risk factor), and higher-risk (two risk factors) groups were recognized with an annual rate of primary outcome of 1.4%, 7.4%, and 20.4%, respectively. A high burden of appropriate ICD therapies (16% per year) and electrical storms were documented, however, ICD interventions did not impact on the primary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among ChHD patients receiving a secondary prevention ICD, older age (\u226565\u2009years) and left ventricular dysfunction (LVEF\u2009&lt;\u200935%) portend a poor outcome and were associated with increased risk of death or heart transplantation. Most patients received appropriate ICD therapies, however, ICD interventions did not impact on the primary outcome.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euz012","type":"journal-article","created":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T12:09:05Z","timestamp":1547899745000},"page":"1070-1078","source":"Crossref","is-referenced-by-count":9,"title":["Predictors of mortality and heart transplantation in patients with Chagas\u2019 cardiomyopathy and ventricular tachycardia treated with implantable cardioverter-defibrillators"],"prefix":"10.1093","volume":"21","author":[{"given":"Wagner L","family":"Gali","sequence":"first","affiliation":[{"name":"Clinical Arrhythmia and Pacemaker Unit, Instituto de Cardiologia do Distrito Federal (IC-DF), Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia (FUC), SQSW 300 Bloco F apto 502, Bras\u00edlia, Brazil"},{"name":"Clinical Medicine Area, Cardiology\/Cardiovascular Laboratory, Faculty of Medicine, University of Brasilia, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro V","family":"Sarabanda","sequence":"additional","affiliation":[{"name":"Clinical Arrhythmia and Pacemaker Unit, Instituto de Cardiologia do Distrito Federal (IC-DF), Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia (FUC), SQSW 300 Bloco F apto 502, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Jos\u00e9 M","family":"Baggio","sequence":"additional","affiliation":[{"name":"Clinical Arrhythmia and Pacemaker Unit, Instituto de Cardiologia do Distrito Federal (IC-DF), Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia (FUC), SQSW 300 Bloco F apto 502, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo F","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Brasilia, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo G","family":"Gomes","sequence":"additional","affiliation":[{"name":"Clinical Arrhythmia and Pacemaker Unit, Instituto de Cardiologia do Distrito Federal (IC-DF), Funda\u00e7\u00e3o Universit\u00e1ria de Cardiologia (FUC), SQSW 300 Bloco F apto 502, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Luiz F","family":"Junqueira","sequence":"additional","affiliation":[{"name":"Clinical Medicine Area, Cardiology\/Cardiovascular Laboratory, Faculty of Medicine, University of Brasilia, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"key":"2019071004560763300_euz012-B1","volume-title":"Estimacion Cuantitativa de la Enfermedad de Chagas en L\u00e3s 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