{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:19:44Z","timestamp":1787008784477,"version":"build-2736575974"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:00:00Z","timestamp":1553040000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French Institute of Health and Medical Research"},{"name":"Toulouse Association for the Study of Rhythm Disturbances"},{"DOI":"10.13039\/501100005630","name":"French Society of Cardiology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005630","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Current guidelines do not propose any age cut-off for the primary prevention implantable cardioverter-defibrillator (ICD). However, the risk\/benefit balance in the very elderly population has not been well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In a multicentre French study assessing patients implanted with an ICD for primary prevention, outcomes among patients aged \u226580\u2009years were compared with &lt;80\u2009years old controls matched for sex and underlying heart disease (ischaemic and dilated cardiomyopathy). A total of 300 ICD recipients were enrolled in this specific analysis, including 150 patients \u226580\u2009years (mean age 81.9\u2009\u00b1\u20092.0\u2009years; 86.7% males) and 150 controls (mean age 61.8\u2009\u00b1\u200910.8\u2009years). Among older patients, 92 (75.6%) had no more than one associated comorbidity. Most subjects in the elderly group got an ICD as part of a cardiac resynchronization therapy procedure (74% vs. 46%, P\u2009&lt;\u20090.0001). After a mean follow-up of 3.0\u2009\u00b1\u20092\u2009years, 53 patients (35%) in the elderly group died, including 38.2% from non cardiovascular causes of death. Similar proportion of patients received \u22651 appropriate therapy (19.4% vs. 21.6%; P\u2009=\u20090.65) in the elderly group and controls, respectively. There was a trend towards more early perioperative events (P\u2009=\u20090.10) in the elderly, with no significant increase in late complications (P\u2009=\u20090.73).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Primary prevention ICD recipients \u226580\u2009years in the real world had relatively low associated comorbidity. Rates of appropriate therapies and device-related complications were similar, compared with younger subjects. Nevertheless, the inherent limitations in interpreting observational data on this particular competing risk situation call for randomized controlled trials to provide definitive answers. Meanwhile, a careful multidisciplinary evaluation is needed to guide patient selection for ICD implantation in the elderly population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/europace\/euz041","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T15:17:56Z","timestamp":1550848676000},"page":"1063-1069","source":"Crossref","is-referenced-by-count":18,"title":["Prophylactic implantable cardioverter-defibrillator in the very elderly"],"prefix":"10.1093","volume":"21","author":[{"given":"Cyril","family":"Zakine","sequence":"first","affiliation":[{"name":"Paris Cardiovascular Research Center, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigue","family":"Garcia","sequence":"additional","affiliation":[{"name":"University Hospital of Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Paris 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