{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T01:14:08Z","timestamp":1772932448582,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T00:00:00Z","timestamp":1556236800000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Patients with heart failure and severe mitral regurgitation (MR) have a poor prognosis and carry an increased risk for ventricular arrhythmias. The present study evaluates the impact of transcatheter mitral valve repair using the MitraClip on the potential reduction of ventricular arrhythmias.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Patients undergoing MitraClip implantation were prospectively enrolled into the present study and received 24\u2009h Holter ECG assessment prior to and 6\u2009months after the procedure. In addition, left ventricular dimensions and function were assessed at baseline and follow-up. A total of 50 patients with mainly functional MR (82%) were included. Non-sustained or sustained ventricular tachycardia (nsVT and\/or sVT) occurred in 32% of patients and was reduced to 14% at follow-up (P\u2009=\u20090.01). Also, premature ventricular complex (PVC) burden \u22655% decreased from 16% to 4% (P\u2009=\u20090.04). Patients with persistent (n\u2009=\u20096) or new (n\u2009=\u20091) nsVT and\/or sVT at follow-up showed a significant decrease in left ventricular ejection fraction from 38% (interquartile range 26\u201345%) to 33% (interquartile range 22\u201344%; P\u2009=\u20090.03).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this prospective study, transcatheter mitral valve repair using MitraClip was associated with a reduced prevalence of ventricular arrhythmias. The subset of patients with persistent or new ventricular arrhythmias after MitraClip implantation showed progression of left ventricular dysfunction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euz061","type":"journal-article","created":{"date-parts":[[2019,3,16]],"date-time":"2019-03-16T02:24:32Z","timestamp":1552703072000},"page":"1385-1391","source":"Crossref","is-referenced-by-count":11,"title":["Impact of transcatheter mitral valve repair on ventricular arrhythmias"],"prefix":"10.1093","volume":"21","author":[{"given":"Jakob","family":"Ledwoch","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, L\u00fcbeck, Germany"},{"name":"German Center for Cardiovascular Research (DZHK)"},{"name":"Department of Cardiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Nommensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, L\u00fcbeck, Germany"},{"name":"German Center for Cardiovascular Research (DZHK)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Keelani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, L\u00fcbeck, Germany"},{"name":"German Center for Cardiovascular Research (DZHK)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roza","family":"Meyer-Saraei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, L\u00fcbeck, Germany"},{"name":"German Center for Cardiovascular Research (DZHK)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Stiermaier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, L\u00fcbeck, Germany"},{"name":"German Center for Cardiovascular Research (DZHK)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, L\u00fcbeck, Germany"},{"name":"German Center for Cardiovascular Research (DZHK)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"P\u00f6ss","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, L\u00fcbeck, Germany"},{"name":"German Center for Cardiovascular Research (DZHK)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Desch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine, University Heart Center L\u00fcbeck, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, L\u00fcbeck, Germany"},{"name":"German Center for Cardiovascular Research (DZHK)"},{"name":"Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Leipzig, 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