{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:46:14Z","timestamp":1789145174853,"version":"build-2803163510"},"reference-count":130,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T00:00:00Z","timestamp":1556323200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Progressive cardiac conduction disease (PCCD) is often a primarily genetic disorder, with clinical and genetic overlaps with other inherited cardiac and metabolic diseases. A number of genes have been implicated in PCCD pathogenesis with or without structural heart disease or systemic manifestations. Precise genetic diagnosis contributes to risk stratification, better selection of specific therapy and allows familiar cascade screening. Cardiologists should be aware of the different phenotypes emerging from different gene-mutations and the potential risk of sudden cardiac death. Genetic forms of PCCD often overlap or coexist with other inherited heart diseases or manifest in the context of multisystem syndromes. Despite the significant advances in the knowledge of the genetic architecture of PCCD and overlapping diseases, in a measurable fraction of PCCD cases, including in familial clustering of disease, investigations of known cardiac disease-associated genes fail to reveal the underlying substrate, suggesting that new causal genes are yet to be discovered. Here, we provide insight into genetics and molecular mechanisms of PCCD and related diseases. We also highlight the phenotypic overlaps of PCCD with other inherited cardiac and metabolic diseases, present unmet challenges in clinical practice, and summarize the available therapeutic options for affected patients.<\/jats:p>","DOI":"10.1093\/europace\/euz109","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T18:07:24Z","timestamp":1553710044000},"page":"1145-1158","source":"Crossref","is-referenced-by-count":56,"title":["Molecular and genetic insights into progressive cardiac conduction disease"],"prefix":"10.1093","volume":"21","author":[{"given":"Babken","family":"Asatryan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital, Freiburgstrasse 8, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argelia","family":"Medeiros-Domingo","sequence":"additional","affiliation":[{"name":"Swiss DNAlysis, Adlerstrasse 1, D\u00fcbendorf, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,26]]},"reference":[{"key":"2019080504543915900_euz109-B1","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1001\/jama.1973.03220400011003","article-title":"Hereditary progressive atrioventricular conduction defect: a new syndrome?","volume":"225","author":"Lynch","year":"1973","journal-title":"JAMA"},{"key":"2019080504543915900_euz109-B2","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1540-8167.2007.01006.x","article-title":"Association of congenital, diffuse electrical disease in children with normal heart: sick sinus syndrome, intraventricular conduction block, and monomorphic ventricular tachycardia","volume":"19","author":"Iturralde-Torres","year":"2008","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2019080504543915900_euz109-B3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jpeds.2007.05.044","article-title":"Cardiac conduction disturbance detected in a pediatric population","volume":"152","author":"Chiu","year":"2008","journal-title":"J Pediatr"},{"key":"2019080504543915900_euz109-B4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0033-0620(64)80001-3","article-title":"Etiology and pathology of bilateral bundle branch block in relation to complete heart block","volume":"6","author":"Lenegre","year":"1964","journal-title":"Progr Cardiovasc Dis"},{"key":"2019080504543915900_euz109-B5","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/0002-9343(64)90022-1","article-title":"Anatomic basis for atrioventricular block","volume":"37","author":"Lev","year":"1964","journal-title":"Am J Med"},{"key":"2019080504543915900_euz109-B6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/jmg.2008.061002","article-title":"20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits","volume":"46","author":"Lalani","year":"2008","journal-title":"J Med Genet"},{"key":"2019080504543915900_euz109-B7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cell.2004.09.011","article-title":"Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism","volume":"119","author":"Splawski","year":"2004","journal-title":"Cell"},{"key":"2019080504543915900_euz109-B8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/CIRCEP.111.967604","article-title":"A connexin40 mutation associated with a malignant variant of progressive familial heart block type I","volume":"5","author":"Makita","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2019080504543915900_euz109-B9","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.recesp.2015.07.010","article-title":"Phenotypic patterns of cardiomyopathy caused by mutations in the desmin gene. 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