{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:02:35Z","timestamp":1780513355450,"version":"3.54.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["HICF-R10-698"],"award-info":[{"award-number":["HICF-R10-698"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome\/EPSRC Centre for Medical Engineering","award":["WT 203148\/Z\/16\/Z"],"award-info":[{"award-number":["WT 203148\/Z\/16\/Z"]}]},{"DOI":"10.13039\/501100000272","name":"National Institute of Health Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010872","name":"King\u2019s College Hospital NHS Foundation Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010872","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["CRTF N001877\/1"],"award-info":[{"award-number":["CRTF N001877\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Potential advantages of real-time magnetic resonance imaging (MRI)-guided electrophysiology (MR-EP) include contemporaneous three-dimensional substrate assessment at the time of intervention, improved procedural guidance, and ablation lesion assessment. We evaluated a novel real-time MR-EP system to perform endocardial voltage mapping and assessment of delayed conduction in a porcine ischaemia\u2013reperfusion model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Sites of low voltage and slow conduction identified using the system were registered and compared to regions of late gadolinium enhancement (LGE) on MRI. The Sorensen\u2013Dice similarity coefficient (DSC) between LGE scar maps and voltage maps was computed on a nodal basis. A total of 445 electrograms were recorded in sinus rhythm (range: 30\u2013186) using the MR-EP system including 138 electrograms from LGE regions. Pacing captured at 103 sites; 47 (45.6%) sites had a stimulus-to-QRS (S-QRS) delay of \u226540\u2009ms. Using conventional (0.5\u20131.5\u2009mV) bipolar voltage thresholds, the sensitivity and specificity of voltage mapping using the MR-EP system to identify MR-derived LGE was 57% and 96%, respectively. Voltage mapping had a better predictive ability in detecting LGE compared to S-QRS measurements using this system (area under curve: 0.907 vs. 0.840). Using an electrical threshold of 1.5\u2009mV to define abnormal myocardium, the total DSC, scar DSC, and normal myocardium DSC between voltage maps and LGE scar maps was 79.0 \u00b1 6.0%, 35.0 \u00b1 10.1%, and 90.4 \u00b1 8.6%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Low-voltage zones and regions of delayed conduction determined using a real-time MR-EP system are moderately associated with LGE areas identified on MRI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euz165","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T15:30:25Z","timestamp":1558539025000},"page":"1432-1441","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of a real-time magnetic resonance imaging-guided electrophysiology system for structural and electrophysiological ventricular tachycardia substrate assessment"],"prefix":"10.1093","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6462-8740","authenticated-orcid":false,"given":"Rahul K","family":"Mukherjee","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Mendonca","family":"Costa","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhouene","family":"Neji","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"},{"name":"Siemens Healthcare, Sir William Siemens Square, Frimley, Camberley, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L","family":"Harrison","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"},{"name":"Department of Cardiology, King\u2019s College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Sim","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E","family":"Williams","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"},{"name":"Department of Cardiology, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Whitaker","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Chubb","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Schneider","sequence":"additional","affiliation":[{"name":"Siemens Healthcare GmbH, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Imricor Medical Systems, 400 Gateway Blvd, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pohl","sequence":"additional","affiliation":[{"name":"Siemens Healthcare GmbH, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Roujol","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A","family":"Niederer","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Razavi","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, King\u2019s College London, 4th Floor, North Wing, St Thomas\u2019 Hospital, London, UK"},{"name":"Department of Cardiology, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, 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