{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:36:36Z","timestamp":1789133796934,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"German Cardiac Society Otto Hess Scholarship 2017"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\u2003<\/jats:title><jats:p>Arrhythmia recurrences after catheter ablation of atrial fibrillation (AF) still remain an important management issue. Recently, the APPLE score had been introduced to predict rhythm outcomes within 12\u2009months after catheter ablation, while the simple MB-LATER score was developed for the prediction of very late recurrence of AF (VLRAF) occurring after 12\u2009months. The aim of this study was to compare APPLE and MB-LATER scores in predicting VLRAF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results\u2003<\/jats:title><jats:p>The study population included arrhythmia-free patients within first 12\u2009months after first radiofrequency catheter ablation from The Heart Center Leipzig AF Ablation Registry. The APPLE [one point for Age &gt;65\u2009years, Persistent AF, imPaired eGFR &lt;60\u2009mL\/min\/1.73 m2, Left atrial (LA) diameter \u226543\u2009mm, EF &lt;50%] and MB-LATER scores [one point for Male gender, Bundle branch block or QRS &gt;120 ms, LA diameter \u226547\u2009mm, AF Type (persistent AF), Early Recurrence &lt;3\u2009months] were calculated before and 3\u2009months after ablation, respectively. We followed 482 patients {age 61 [interquartile range (IQR) 54\u201368] years, 66% males, 32% persistent AF} for median 40 (IQR 35\u201350) months. There were 184 patients (38.3%) with arrhythmia recurrences within 13\u201360\u2009months after ablation. On multivariate analysis, APPLE [odds ratio (OR) 1.517, 95% confidence interval (CI) 1.244\u20131.850, P\u2009&lt;\u20090.001] and MB-LATER (OR 1.437, 95% CI 1.211\u20131.705, P\u2009&lt;\u20090.001) scores and diabetes mellitus (OR 2.214, 95% CI 1.353\u20133.625, P\u2009=\u20090.002) were significantly associated with arrhythmia recurrences. Receiver operating characteristic curve analyses demonstrated moderate prediction for both scores [area under the curve (AUC) 0.607, P\u2009&lt;\u20090.001 for APPLE score, AUC 0.604, P\u2009&lt;\u20090.001 for MB-LATER].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion\u2003<\/jats:title><jats:p>Prediction of VLRAF is similar for both APPLE and MB-LATER scores. A better score remains still a clinical unmet need.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euz233","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T19:09:44Z","timestamp":1564513784000},"page":"1646-1652","source":"Crossref","is-referenced-by-count":13,"title":["Very late arrhythmia recurrences in patients with sinus rhythm within the first year after catheter ablation: The Leipzig Heart Center AF Ablation Registry"],"prefix":"10.1093","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3551-1145","authenticated-orcid":false,"given":"Jelena","family":"Kornej","sequence":"first","affiliation":[{"name":"Department of Electrophysiology, Heart Center, Struempellstrasse 39, Leipzig, Germany"},{"name":"University of Leipzig, Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-9442","authenticated-orcid":false,"given":"Katja","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center, Struempellstrasse 39, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center, Struempellstrasse 39, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Potpara","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, Clinical Center of Serbia, Vi\u0161egradska 26, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center, Struempellstrasse 39, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Dagres","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center, Struempellstrasse 39, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Bollmann","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center, Struempellstrasse 39, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Husser-Bollmann","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center, Struempellstrasse 39, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Hindricks","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Heart Center, Struempellstrasse 39, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"2019110403561677500_euz233-B1","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/europace\/euw295","article-title":"2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"18","author":"Kirchhof","year":"2016","journal-title":"Europace"},{"key":"2019110403561677500_euz233-B2","doi-asserted-by":"crossref","first-page":"e004549.","DOI":"10.1161\/JAHA.112.004549","article-title":"Long-term outcomes of catheter ablation of atrial fibrillation: a systematic review and meta-analysis","volume":"2","author":"Ganesan","year":"2013","journal-title":"J Am Heart 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