{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T17:45:52Z","timestamp":1776188752276,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Andalusian Society of Cardiology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Permanent His bundle pacing (p-HBP) can correct intraventricular conduction disorders and could be an alternative to traditional cardiac resynchronization therapy (CRT) via the coronary sinus. We describe the short-term impact of HBP on left ventricular ejection fraction (LVEF) and improvement of left intraventricular synchrony.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>This prospective descriptive study, performed from January 2018 to February 2019, included patients with left bundle branch block (LBBB) and an CRT indication who were resynchronized by p-HBP. We used the Medtronic C315 His catheter or a combination of the CPS-Direct-Universal introducer, CPS-AIM\u2122-Universal subselector (Abbot), and SelectSecure\u2122 MRI-SureScan\u2122 3830 lead. Correction of the LBBB by HBP had been previously checked. At 1\u2009month of follow-up, we analysed the quantification of LVEF and measurement of the delay of the septal wall with the posterior wall as a parameter of intraventricular synchrony. We included 48 patients with LBBB and an indication for CRT. With HBP, we corrected the LBBB in 81% of patients (n\u2009=\u200939), and we achieved cardiac resynchronization through permanent HBP in 92% of these patients (n\u2009=\u200936). Left ventricular ejection fraction and intraventricular mechanical resynchronization improved in all patients, which was demonstrated by echocardiography through the improvement of the delay of the septal wall with the posterior wall from 138\u2009ms (range 131\u2013151) to 41\u2009ms (19\u201363).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>There is early improvement after p-HBP in LVEF and left ventricular electromechanical synchronization in patients with LBBB, heart failure, and an indication for CRT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euz296","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T07:36:26Z","timestamp":1570174586000},"source":"Crossref","is-referenced-by-count":8,"title":["Early improvement of left ventricular ejection fraction by cardiac resynchronization through His bundle pacing in patients with heart failure"],"prefix":"10.1093","author":[{"given":"Pablo","family":"Mori\u00f1a-V\u00e1zquez","sequence":"first","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology, Hospital Juan Ramon Jimenez (HJRJ), Ronda norte s\/n. Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7114-973X","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Moraleda-Salas","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology, Hospital Juan Ramon Jimenez (HJRJ), Ronda norte s\/n. Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Jos\u00e9","family":"Manovel-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Cardiac Imaging Unit, Department of Cardiology, Hospital Juan Ramon Jimenez (HJRJ), Ronda norte s\/n. Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Fern\u00e1ndez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology, Hospital Juan Ramon Jimenez (HJRJ), Ronda norte s\/n. Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Arce-L\u00e9on","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology, Hospital Juan Ramon Jimenez (HJRJ), Ronda norte s\/n. Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Venegas-Gamero","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology, Hospital Juan Ramon Jimenez (HJRJ), Ronda norte s\/n. Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Barba-Pichardo","sequence":"additional","affiliation":[{"name":"Arrhythmia Unit, Department of Cardiology, Hospital Juan Ramon Jimenez (HJRJ), Ronda norte s\/n. Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"2019112009202813200_euz296-B1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1161\/01.CIR.101.8.869","article-title":"Permanent, direct His-bundle pacing: a novel approach to cardiac pacing in patients with normal His-Purkinje activation","volume":"101","author":"Deshmukh","year":"2000","journal-title":"Circulation"},{"key":"2019112009202813200_euz296-B2","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/S0300-8932(01)76521-9","article-title":"Estimulaci\u00f3n permanente del haz de His tras ablaci\u00f3n mediante radiofrecuencia del nodo auriculoventricular en pacientes con trastorno de la conducci\u00f3n suprahisiano","volume":"54","author":"Mori\u00f1a-V\u00e1zquez","year":"2001","journal-title":"Rev Esp Cardiol"},{"key":"2019112009202813200_euz296-B3","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1161\/01.CIR.56.6.996","article-title":"Longitudinal dissociation in the His bundle. Bundle branch block due to asynchronous conduction within the His bundle in man","volume":"56","author":"Narula","year":"1977","journal-title":"Circulation"},{"key":"2019112009202813200_euz296-B4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.CIR.57.3.473","article-title":"Normalization of bundle branch patterns by distal His bundle pacing. Clinical and experimental evidence of longitudinal dissociation in the pathologic His bundle","volume":"57","author":"El-Sherif","year":"1978","journal-title":"Circulation"},{"key":"2019112009202813200_euz296-B5","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1540-8159.2005.00150.x","article-title":"Cardiac resynchronization through selective His bundle pacing in a patient the so-called infra His atrioventricular block","volume":"28","author":"Mori\u00f1a-V\u00e1zquez","year":"2005","journal-title":"Pacing Clin Electrophysiol"},{"key":"2019112009202813200_euz296-B6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.hrthm.2009.09.066","article-title":"Electrical resynchronization induced by direct His-bundle pacing","volume":"7","author":"Lustgarten","year":"2010","journal-title":"Heart Rhythm"},{"key":"2019112009202813200_euz296-B7","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.hlc.2011.05.617","article-title":"Electrical and mechanical cardiac resynchronization by novel direct His-bundle pacing in a heart failure patient","volume":"20","author":"Manovel","year":"2011","journal-title":"Heart Lung Circ"},{"key":"2019112009202813200_euz296-B8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/europace\/eus228","article-title":"Ventricular resynchronization therapy by direct His-bundle pacing using an internal cardioverter defibrillator","volume":"15","author":"Barba-Pichardo","year":"2013","journal-title":"Europace"},{"key":"2019112009202813200_euz296-B9","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.hrthm.2017.04.003","article-title":"Permanent His-bundle pacing for cardiac resynchronization therapy: initial feasibility study in lieu of left ventricular lead","volume":"14","author":"Ajijola","year":"2017","journal-title":"Heart 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transeptal de ventr\u00edculo izquierdo v\u00eda venosa femoral","volume":"62","author":"Mori\u00f1a-V\u00e1zquez","year":"2009","journal-title":"Rev Esp Cardiol"},{"key":"2019112009202813200_euz296-B15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/europace\/euq038","article-title":"Permanent His-bundle pacing: seeking physiological ventricular pacing","volume":"12","author":"Barba-Pichardo","year":"2010","journal-title":"Europace"},{"key":"2019112009202813200_euz296-B16","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.hrthm.2015.03.048","article-title":"His-bundle pacing versus biventricular pacing in cardiac resynchronization therapy patients: a crossover design comparison","volume":"12","author":"Lustgarten","year":"2015","journal-title":"Heart Rhythm"},{"key":"2019112009202813200_euz296-B17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/heartjnl-2018-313415","article-title":"Long-term outcomes of His bundle pacing in patients 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