{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T17:09:22Z","timestamp":1771607362689,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cost neutral study"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Although cryoballoon pulmonary vein isolation is a well-established treatment for paroxysmal atrial fibrillation (AF), it\u2019s role in persistent AF is unclear. We examined procedural success and long-term outcomes of cryoablation in persistent and longstanding persistent AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>International multicentre registry from three UK and eight European centres. Consecutive patients undergoing cryoablation for persistent AF included. Procedural data, complications, and follow-up were prospectively recorded. Patients were followed-up at 3, 6, and 12\u2009months with an electrocardiogram with open access to arrhythmia nurses thereafter. Ambulatory monitoring was dictated by symptoms. Success was defined as freedom from AF or atrial tachycardia lasting &amp;gt;30\u2009s off antiarrhythmic drugs (AADs). Six hundred and nine consecutive cryoablation procedures. Mean procedure and fluoroscopy times were 95\u2009\u00b1\u200965 and 13\u2009\u00b1\u200910\u2009min. Single procedure success rates were 368\/602 (61%) off AADs over a median of 2.4 (1.0\u20134.0) years. Arrhythmia-free survival off AADs was 64% and 57% for persistent and longstanding persistent AF at 24\u2009months of follow-up (P\u2009=\u20090.02). Rate of repeat ablations was 20% in persistent and 32% in longstanding persistent AF (P\u2009=\u20090.006). Cox regression analyses showed a significant association between duration of AF and left atrial diameter and arrhythmia recurrence [hazard ratio (HR) 1.05, P-value 0.01 and HR 1.02, P-value 0.004].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cryoablation for persistent AF is safe, fast and has good outcomes at long-term follow-up. Cryoablation is reasonable as a first line option for these patients. Short procedure times may help increase capacity of cardiac units to meet the rising demand for AF ablation. Randomised control trials are needed to compare outcomes with different techniques.<\/jats:p><\/jats:sec>","DOI":"10.1093\/europace\/euz313","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T20:13:20Z","timestamp":1573762400000},"page":"375-381","source":"Crossref","is-referenced-by-count":36,"title":["Cryoablation for persistent and longstanding persistent atrial fibrillation: results from a multicentre European registry"],"prefix":"10.1093","volume":"22","author":[{"given":"Vinit","family":"Sawhney","sequence":"first","affiliation":[{"name":"Department of Arrhythmia Services, The Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J","family":"Schilling","sequence":"first","affiliation":[{"name":"Department of Arrhythmia Services, The Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Providencia","sequence":"first","affiliation":[{"name":"Department of Arrhythmia Services, The Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Cadd","sequence":"first","affiliation":[{"name":"Department of Arrhythmia Services, The Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhanuka","family":"Perera","sequence":"first","affiliation":[{"name":"Department of Arrhythmia Services, The Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salman","family":"Chatha","sequence":"first","affiliation":[{"name":"Department of Arrhythmia Services, The Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Mercer","sequence":"first","affiliation":[{"name":"West Yorkshire Arrhythmia Service, Leeds General Infirmary, Leeds, LS1 3EX, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Finlay","sequence":"first","affiliation":[{"name":"Department of Arrhythmia Services, The Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck","family":"Halimi","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Prive Parly 2, Le Chesnay, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Pavin","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Pontchaillou of Rennes, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Anselme","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital of Rouen, Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Cebron","sequence":"first","affiliation":[{"name":"Department of Cardiology, Nouvelles Cliniques Nantaises, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongi","family":"Chun","sequence":"first","affiliation":[{"name":"Department of Cardiology, Medizinische Klinik 3, Markuskrankenhaus, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Cardiology, Medizinische Klinik 3, Markuskrankenhaus, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Defaye","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital of Grenoble, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurpreet","family":"Dhillon","sequence":"first","affiliation":[{"name":"Department of Arrhythmia Services, The Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Boveda","sequence":"first","affiliation":[{"name":"Department of Cardiology, Clinique Pasteur, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Albenque","sequence":"first","affiliation":[{"name":"Department of Cardiology, Clinique Pasteur, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muzahir","family":"Tayebjee","sequence":"first","affiliation":[{"name":"West 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Cryoballoon or radiofrequency ablation for symptomatic paroxysmal atrial fibrillation: reintervention, rehospitalization, and quality-of-life outcomes in the FIRE AND ICE trial","volume":"37","author":"Kuck","year":"2016","journal-title":"Eur Heart J"},{"key":"2020030603532543300_euz313-B9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jjcc.2016.02.007","article-title":"Cryoballoon ablation for persistent atrial fibrillation\u2014large single-center experience","volume":"68","author":"Straube","year":"2016","journal-title":"J Cardiol"},{"key":"2020030603532543300_euz313-B10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.hrthm.2014.09.063","article-title":"Pulmonary vein isolation as index procedure for persistent atrial fibrillation: one-year clinical outcome after ablation using the second-generation cryoballoon","volume":"12","author":"Ciconte","year":"2015","journal-title":"Heart Rhythm"},{"key":"2020030603532543300_euz313-B11","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1161\/CIRCEP.114.002504","article-title":"No benefit of complex fractionated atrial electrogram ablation in addition to circumferential pulmonary vein ablation and linear ablation: benefit of complex ablation study","volume":"8","author":"Wong","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2020030603532543300_euz313-B12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/CIRCEP.113.000890","article-title":"Selective complex fractionated atrial electrograms targeting for atrial fibrillation study (SELECT AF): a multicenter, randomized trial","volume":"7","author":"Verma","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2020030603532543300_euz313-B13","doi-asserted-by":"crossref","first-page":"e005114","DOI":"10.1161\/CIRCEP.117.005114","article-title":"Stand-alone pulmonary vein isolation versus pulmonary vein isolation with additional substrate modification as index ablation procedures in patients with persistent and long-standing persistent atrial fibrillation: the Randomized Alster-Lost-AF Trial (Ablation at St. Georg Hospital for Long-Standing Persistent Atrial Fibrillation)","volume":"10","author":"Fink","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2020030603532543300_euz313-B14","doi-asserted-by":"crossref","first-page":"e005767","DOI":"10.1161\/CIRCEP.117.005767","article-title":"Laser balloon or wide-area circumferential irrigated radiofrequency ablation for persistent atrial fibrillation: a multicenter prospective randomized study","volume":"10","author":"Schmidt","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2020030603532543300_euz313-B15","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.jacc.2012.11.064","article-title":"Cryoballoon ablation of pulmonary veins for paroxysmal atrial fibrillation: first results of the North American Arctic Front (STOP AF) pivotal trial","volume":"61","author":"Packer","year":"2013","journal-title":"J Am Coll Cardiol"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/22\/3\/375\/32793649\/euz313.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/22\/3\/375\/32793649\/euz313.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T07:17:58Z","timestamp":1612336678000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/22\/3\/375\/5662413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,6]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,12,6]]},"published-print":{"date-parts":[[2020,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euz313","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,3]]},"published":{"date-parts":[[2019,12,6]]}}}