{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:33:46Z","timestamp":1771472026138,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V104C-131"],"award-info":[{"award-number":["V104C-131"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V104E7-003"],"award-info":[{"award-number":["V104E7-003"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V105C-60"],"award-info":[{"award-number":["V105C-60"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V106C-114"],"award-info":[{"award-number":["V106C-114"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V107C-099"],"award-info":[{"award-number":["V107C-099"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["VGHUST107-G1-8\u20131"],"award-info":[{"award-number":["VGHUST107-G1-8\u20131"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 104-2314-B-075-065-MY2"],"award-info":[{"award-number":["MOST 104-2314-B-075-065-MY2"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 106-2314-B-010-054"],"award-info":[{"award-number":["MOST 106-2314-B-010-054"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Foundation of Cardiovascular Medicine","award":["RFCM 101-01-001"],"award-info":[{"award-number":["RFCM 101-01-001"]}]},{"name":"Research Foundation of Cardiovascular Medicine","award":["104-01-009-01"],"award-info":[{"award-number":["104-01-009-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Both obesity and heart failure (HF) are associated with sudden cardiac death. The current study aimed to investigate the effects of overweight and HF on the substrate for ventricular fibrillation (VF), and whether renal denervation (RDN) can protect the heart from sympathetic activation and cardiac remodelling in HF rabbits fed with high-fat diet (HFD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Twenty-four rabbits randomized into control group fed with regular diet (Control), HFD, HFD-HF, and HFD-HF-RDN groups. Rapid ventricular pacing of 400 b.p.m. for 4 weeks was applied in HFD-HF and HFD-HF-RDN. Surgical and chemical RDNs were approached through bilateral retroperitoneal flank incisions in HFD-HF-RDN. All rabbits received electrophysiological study and a VF inducibility test. The ventricular myocardium was harvested for trichrome stain. After 3 months, mean body weight was heavier in HFD, compared with control (3.5\u2009\u00b1\u20090.1\u2009kg vs. 2.6\u2009\u00b1\u20090.1\u2009kg, P\u2009&amp;lt;\u20090.01). No differences in body weight among the three groups fed with HFD were observed. The ventricular refractory periods were longer in HFD-HF and HFD-HF-RDN than in control. An extension of ventricular fibrosis was observed in HFD and HFD-HF compared with control, and the degree of ventricular fibrosis was suppressed in HFD-HF-RDN compared with HFD-HF. The level of tyrosine hydroxylase staining was reduced in HFD-HF-RDN compared with HFD and HFD-HF. Importantly, VF inducibility was lower in HFD-RDN-HF (10\u2009\u00b1\u20094%), when compared with those in HFD-HF (58\u2009\u00b1\u200910%, P\u2009&amp;lt;\u20090.01) and HFD (42\u2009\u00b1\u20095%, P\u2009&amp;lt;\u20090.05), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our results suggest that overweight and HF increase sympathetic activity, structural remodelling, and VF inducibility, but RDN prevents them.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euz335","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T20:43:10Z","timestamp":1575319390000},"page":"657-666","source":"Crossref","is-referenced-by-count":18,"title":["Renal denervation ameliorates the risk of ventricular fibrillation in overweight and heart failure"],"prefix":"10.1093","volume":"22","author":[{"given":"Shinya","family":"Yamada","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei 11217, Taiwan"},{"name":"Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Wei","family":"Lo","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei 11217, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Institute, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hui","family":"Chou","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei 11217, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Lun","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei 11217, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Institute, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Lin","family":"Chang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei 11217, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Institute, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yenn-Jiang","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei 11217, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Institute, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Huei","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei 11217, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Institute, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Han","family":"Cheng","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei 11217, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Institute, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Ying","family":"Tsai","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei 11217, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Institute, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Ann","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou District, Taipei 11217, Taiwan"},{"name":"Institute of Clinical Medicine, and Cardiovascular Research Institute, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"2020040604554313200_euz335-B1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jacc.2007.03.045","article-title":"Left stellate ganglion and vagal nerve activity and cardiac arrhythmia in ambulatory dogs with pacing-induced congestive heart failure","volume":"50","author":"Ogawa","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2020040604554313200_euz335-B2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1056\/NEJMoa020245","article-title":"Obesity and the risk of heart failure","volume":"347","author":"Kenchaiah","year":"2002","journal-title":"N Engl J Med"},{"key":"2020040604554313200_euz335-B3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0002-8703(95)90008-X","article-title":"Cardiac conduction system involvement in sudden death of obese young people","volume":"129","author":"Bharatti","year":"1995","journal-title":"Am Heart J"},{"key":"2020040604554313200_euz335-B4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1056\/NEJM198809153191101","article-title":"Use of the automatic external defibrillator in the management of out-of-hospital cardiac arrest","volume":"319","author":"Weaver","year":"1988","journal-title":"N Engl J Med"},{"key":"2020040604554313200_euz335-B5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1540-8167.2006.00680.x","article-title":"Obesity as a risk factor for sustained ventricular tachyarrhythmias in MADIT II patients","volume":"18","author":"Pietrasik","year":"2007","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2020040604554313200_euz335-B6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.hrthm.2012.08.043","article-title":"Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation","volume":"10","author":"Abed","year":"2013","journal-title":"Heart Rhythm"},{"key":"2020040604554313200_euz335-B7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/apha.12185","article-title":"Ventricular remodelling in rabbits with sustained high-fat diet","volume":"211","author":"Zarzoso","year":"2014","journal-title":"Acta Physiol"},{"key":"2020040604554313200_euz335-B8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.lfs.2009.04.020","article-title":"Cardiac impairment in rabbits fed a high-fat diet is counteracted by dehydroepiandrosterone supplementation","volume":"85","author":"Aragno","year":"2009","journal-title":"Life Sci"},{"key":"2020040604554313200_euz335-B9","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/ejhf.83","article-title":"Renal denervation and heart failure","volume":"16","author":"B\u00f6hm","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"2020040604554313200_euz335-B10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ijcard.2017.02.085","article-title":"Renal denervation regulates the atrial arrhythmogenic substrates through reverse structural remodeling in heart failure rabbit model","volume":"235","author":"Yamada","year":"2017","journal-title":"Int J Cardiol"},{"key":"2020040604554313200_euz335-B11","doi-asserted-by":"crossref","first-page":"e004479","DOI":"10.1161\/JAHA.116.004479","article-title":"Beneficial effect of renal denervation on ventricular premature complex induced cardiomyopathy","volume":"6","author":"Yamada","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2020040604554313200_euz335-B12","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.hrthm.2013.07.015","article-title":"Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs","volume":"10","author":"Linz","year":"2013","journal-title":"Heart Rhythm"},{"key":"2020040604554313200_euz335-B13","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.cardiores.2006.12.001","article-title":"Autonomic modulation of electrical restitution, alternans and ventricular fibrillation initiation in the isolated heart","volume":"73","author":"Ng","year":"2007","journal-title":"Cardiovasc Res"},{"key":"2020040604554313200_euz335-B14","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/0735-1097(92)90503-F","article-title":"Electrophysiologic substrate associated with pacing-induced heart failure in dogs: potential value of programmed stimulation in predicting sudden death","volume":"19","author":"Li","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"2020040604554313200_euz335-B15","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/hy0202.104398","article-title":"Chronic cardiovascular and renal actions of leptin: role of adrenergic activity","volume":"39","author":"Carlyle","year":"2002","journal-title":"Hypertension"},{"key":"2020040604554313200_euz335-B16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.hrthm.2016.10.003","article-title":"Effects of renal sympathetic denervation on the stellate ganglion and brain stem in dogs","volume":"14","author":"Tsai","year":"2017","journal-title":"Heart Rhythm"},{"key":"2020040604554313200_euz335-B17","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.jacc.2009.05.015","article-title":"The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications","volume":"54","author":"Triposkiadis","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2020040604554313200_euz335-B18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1113\/EP086472","article-title":"Antifibrillatory effects of renal denervation on ventricular fibrillation in a canine model of pacing-induced heart failure","volume":"103","author":"Luo","year":"2018","journal-title":"Exp Physiol"},{"key":"2020040604554313200_euz335-B19","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1113\/expphysiol.2014.082057","article-title":"Renal sympathetic denervation modulates ventricular electrophysiology and has a protective effect on ischemia-induced ventricular arrhythmia","volume":"99","author":"Huang","year":"2014","journal-title":"Exp Physiol"},{"key":"2020040604554313200_euz335-B20","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1159\/000452561","article-title":"Renal denervation attenuates multi-organ fibrosis and improves vascular remodeling in rats with transverse aortic constriction induced cardiomyopathy","volume":"40","author":"Wang","year":"2016","journal-title":"Cell Physiol Biochem"}],"container-title":["EP Europace"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/22\/4\/657\/32991507\/euz335.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/europace\/article-pdf\/22\/4\/657\/32991507\/euz335.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T08:56:58Z","timestamp":1586163418000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/europace\/article\/22\/4\/657\/5717443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,29]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,1,29]]},"published-print":{"date-parts":[[2020,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/europace\/euz335","relation":{},"ISSN":["1099-5129","1532-2092"],"issn-type":[{"value":"1099-5129","type":"print"},{"value":"1532-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2020,1,29]]}}}