{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:37:48Z","timestamp":1788327468576,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["32003B_165802"],"award-info":[{"award-number":["32003B_165802"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004362","name":"Swiss Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biologic Delivery Systems, Division of Biosense Webster a Johnson & Johnson Company"},{"DOI":"10.13039\/100007771","name":"Medical University of Silesia","doi-asserted-by":"publisher","award":["KNW-1-135\/N\/6\/K"],"award-info":[{"award-number":["KNW-1-135\/N\/6\/K"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007771","name":"Medical University of Silesia","doi-asserted-by":"publisher","award":["POIG.01.01.02-00-109\/09"],"award-info":[{"award-number":["POIG.01.01.02-00-109\/09"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The aim of this study was to determine the relationship between electrical and mechanical activation in heart failure (HF) patients and whether electromechanical coupling is affected by scar.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Seventy HF patients referred for cardiac resynchronization therapy or biological therapy underwent endocardial anatomo-electromechanical mapping (AEMM) and delayed-enhancement magnetic resonance (CMR) scans. Area strain and activation times were derived from AEMM data, allowing to correlate mechanical and electrical activation in time and space with unprecedented accuracy. Special attention was paid to the effect of presence of CMR-evidenced scar. Patients were divided into a scar (n\u2009=\u200943) and a non-scar group (n\u201327). Correlation between time of electrical and mechanical activation was stronger in the non-scar compared to the scar group [R\u2009=\u20090.84 (0.72\u20130.89) vs. 0.74 (0.52\u20130.88), respectively; P\u2009=\u20090.01]. The overlap between latest electrical and mechanical activation areas was larger in the absence than in presence of scar [72% (54\u201381) vs. 56% (36\u201373), respectively; P\u2009=\u20090.02], with smaller distance between the centroids of the two regions [10.7 (4.9\u201317.4) vs. 20.3 (6.9\u201329.4) % of left ventricular radius, P\u2009=\u20090.02].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Scar decreases the association between electrical and mechanical activation, even when scar is remote from late activated regions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/europace\/euz346","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T20:11:01Z","timestamp":1575576661000},"page":"777-786","source":"Crossref","is-referenced-by-count":15,"title":["The influence of scar on the spatio-temporal relationship between electrical and mechanical activation in heart failure patients"],"prefix":"10.1093","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7364-3734","authenticated-orcid":false,"given":"Francesco","family":"Maffessanti","sequence":"first","affiliation":[{"name":"Center for Computational Medicine in Cardiology, Universit\u00e0 della Svizzera italiana, Via G. Buffi 13, CH-6900 Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Jadczyk","sequence":"first","affiliation":[{"name":"Division of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland"},{"name":"Interventional Cardiac Electrophysiology Group, International Clinical Research Center, St. Anne\u2019s University Hospital Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rados\u0142aw","family":"Kurzelowski","sequence":"first","affiliation":[{"name":"Division of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Regoli","sequence":"first","affiliation":[{"name":"Division of Cardiology, Fondazione Cardiocentro Ticino, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luce","family":"Caputo","sequence":"first","affiliation":[{"name":"Division of Cardiology, Fondazione Cardiocentro Ticino, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Conte","sequence":"first","affiliation":[{"name":"Division of Cardiology, Fondazione Cardiocentro Ticino, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof S","family":"Go\u0142ba","sequence":"first","affiliation":[{"name":"Department of Electrocardiology and Heart Failure, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Biernat","sequence":"first","affiliation":[{"name":"Department of Electrocardiology and Heart Failure, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Wilczek","sequence":"first","affiliation":[{"name":"Department of Electrocardiology and Heart Failure, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"D\u0105browska","sequence":"first","affiliation":[{"name":"Department of Electrocardiology and Heart Failure, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Pezzuto","sequence":"first","affiliation":[{"name":"Center for Computational Medicine in Cardiology, Universit\u00e0 della Svizzera italiana, Via G. Buffi 13, CH-6900 Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziano","family":"Moccetti","sequence":"first","affiliation":[{"name":"Division of Cardiology, Fondazione Cardiocentro Ticino, Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Krause","sequence":"first","affiliation":[{"name":"Center for Computational Medicine in Cardiology, Universit\u00e0 della Svizzera italiana, Via G. Buffi 13, CH-6900 Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Wojakowski","sequence":"first","affiliation":[{"name":"Division of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits W","family":"Prinzen","sequence":"first","affiliation":[{"name":"Department of Physiology, CARIM, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Auricchio","sequence":"first","affiliation":[{"name":"Center for Computational Medicine in Cardiology, Universit\u00e0 della Svizzera italiana, Via G. 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