{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:53:01Z","timestamp":1781005981429,"version":"3.54.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Danish Parliament"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Relying on medication for musculoskeletal and mental disorders are common, but may have long-term consequences. This study investigates whether use of analgesics and anxiolytic\/sedative\/hypnotic (ASH) medication increases the risk of disability pension and mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>After completing a survey in 2005, 7773 female eldercare workers were followed for 11\u2009years in a national register. We estimated hazard ratios (HRs) for disability pension and mortality from using analgesics and ASH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During follow-up, 10.3% obtained disability pension and 2.4% died. For use of analgesics, a frequency-response association for the risk of disability pension existed with HR\u2019s (95% confidence interval) of 1.30 (1.07\u20131.57), 2.00 (1.62\u20132.46) and 3.47 (2.69\u20134.47) for monthly, weekly and daily use, respectively. For ASH, an increased risk of disability pension also existed (HR\u2019s between 1.51 and 1.64). For mortality risk, only daily use of analgesics and ASH remained significant. Population attributable fractions of analgesics and ASH, respectively, were 30% and 3% for disability pension and 5% and 3% for mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Frequent use of analgesics and ASH medication in workers increase the risk of disability pension and early death. Better management of musculoskeletal and mental health conditions, without excessive medication use, is necessary.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/eurpub\/ckad064","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T13:52:35Z","timestamp":1686318755000},"page":"601-605","source":"Crossref","is-referenced-by-count":7,"title":["Analgesics and ASH medications in workers increase the risk of disability pension and mortality: prospective cohort"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2777-8085","authenticated-orcid":false,"given":"Lars Louis","family":"Andersen","sequence":"first","affiliation":[{"name":"National Research Centre for the Working Environment , Copenhagen, Denmark"},{"name":"Department of Health Science and Technology, Aalborg University , Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Vinstrup","sequence":"additional","affiliation":[{"name":"National Research Centre for the Working Environment , Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Calatayud","sequence":"additional","affiliation":[{"name":"National Research Centre for the Working Environment , Copenhagen, Denmark"},{"name":"Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia , Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7865-3429","authenticated-orcid":false,"given":"Rub\u00e9n","family":"L\u00f3pez-Bueno","sequence":"additional","affiliation":[{"name":"National Research Centre for the Working Environment , Copenhagen, Denmark"},{"name":"Department of Physical Medicine and Nursing, University of Zaragoza, C. de Pedro Cerbuna , 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