{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:12:28Z","timestamp":1793812348243,"version":"4.6.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007137","name":"Northern Norway Regional Health Authority","doi-asserted-by":"publisher","award":["HNF-156321"],"award-info":[{"award-number":["HNF-156321"]}],"id":[{"id":"10.13039\/501100007137","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Adverse childhood experiences (ACEs) are highly prevalent and associated with life-long health consequences. Here, we investigated the relationship of ACEs to adult-onset health outcomes in general population. We conducted a cross-sectional analysis using the seventh survey of the Troms\u00f8 Study, including 20\u2009843 participants. Main exposure variables were exposure to at least one ACE, rumination related to adverse experiences, cumulative ACEs, and two clusters of ACEs, i.e. interpersonal and impersonal ACEs. Logistic and ordinal regression models were fitted to estimate the risk of adult-onset physical illness and poor self-rated health adjusted for birth year, sex, smoking, education, and income. We found that exposure to at least one ACE together with rumination was associated with increased risk of hypertension, heart failure, atrial fibrillation, diabetes, obesity, kidney disease, chronic obstructive pulmonary disease, asthma, rheumatoid arthritis, arthrosis, migraine, chronic pain, and poor self-rated health. We observed dose\u2013effect relationships of cumulative ACEs to the aggregated risk of 14 among 16 health outcomes. While increased risk of heart failure, kidney disease, and rheumatoid arthritis was only linked to the interpersonal ACEs, increased risk of coronary artery disease was associated only with the impersonal ACEs. Our findings demonstrate that exposure to ACEs increases the risk of adult-onset physical illness and poor self-rated health in a dose\u2013effect relationship, and rumination related to adverse experiences is associated with an aggravated risk. Inquiry into exposure to ACEs might inform about health risks. Early intervention approaches to promote positive experiences and increase resilience might alleviate life-long health burden.<\/jats:p>","DOI":"10.1093\/eurpub\/ckaf031","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T03:06:18Z","timestamp":1744081578000},"page":"498-504","source":"Crossref","is-referenced-by-count":4,"title":["Association of adverse childhood experiences with physical illness and self-rated health in the population-based Troms\u00f8 Study"],"prefix":"10.1093","volume":"35","author":[{"given":"Safak","family":"Caglayan","sequence":"first","affiliation":[{"name":"Division of Mental Health and Substance Abuse, University Hospital of North Norway , Tromso,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"H\u00f8ye","sequence":"additional","affiliation":[{"name":"Division of Mental Health and Substance Abuse, University Hospital of North Norway , Tromso,","place":["Norway"]},{"name":"Department of Clinical Medicine, UiT Arctic University of Norway , Tromso,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens C","family":"Thimm","sequence":"additional","affiliation":[{"name":"Department of Psychology, UiT Arctic University of Norway , Tromso,","place":["Norway"]},{"name":"Centre for Crisis Psychology, University of Bergen , Bergen,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina E A","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Psychology, UiT Arctic University of Norway , Tromso,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole K","family":"Gr\u00f8nli","sequence":"additional","affiliation":[{"name":"Division of Mental Health and Substance Abuse, University Hospital of North Norway , Tromso,","place":["Norway"]},{"name":"Department of Clinical Medicine, UiT Arctic University of Norway , Tromso,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"2025062516061328000_ckaf031-B1","doi-asserted-by":"crossref","first-page":"m3048","DOI":"10.1136\/bmj.m3048","article-title":"Adversity in childhood is linked to mental and physical health throughout life","volume":"371","author":"Nelson","year":"2020","journal-title":"BMJ"},{"key":"2025062516061328000_ckaf031-B2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the adverse childhood experiences (ACE) study","volume":"14","author":"Felitti","year":"1998","journal-title":"Am J Prev Med"},{"key":"2025062516061328000_ckaf031-B3","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/wps.21122","article-title":"Adverse childhood experiences: a 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