{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T11:41:01Z","timestamp":1760614861612,"version":"build-2065373602"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Value-Based Healthcare for Outcomes in Breast and Lung Cancer in Europe"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Improvements in breast cancer survival rate have been achieved through a variety of multimodal therapeutic approaches, which play a key role in the patients\u2019 healthcare pathway and their Patient-Reported Outcomes (PROs) from a Value-Based Healthcare (VBHC) perspective. This paper analyses differences in PROs of patients diagnosed with breast cancer according to their healthcare pathway. A cohort of 690 patients diagnosed with breast cancer between 2018 and 2020 at six European sites was used. PROs were assessed at baseline and 6\u2009months using the International Consortium for Health Outcome Measures standard set. Archetypes defined by patient characteristics and treatment trajectories served as the basis for comparison. Multivariate linear regression models were used to analyse differences in PROs across archetypes. Functional scores generally worsened over 6\u2009months, particularly in physical functioning, whereas emotional functioning improved. Archetypes undergoing mastectomy, with or without reconstruction, showed significant decreases in body image perception and satisfaction with breasts. Pain, fatigue, and peripheral symptoms were prevalent in most archetypes, with those receiving chemotherapy reporting the greatest symptom burden. Patients with in situ carcinoma and patients undergoing conservative surgery plus radiotherapy showed minimal deterioration. The use of PROs in a real-world setting enables the identification of differences across patient archetypes based on their therapeutic pathways. This information provides valuable insights for refining patient-centred care guiding VBHC strategies in oncology, developing of personalized care solutions, and facilitating Shared-Decision Making.<\/jats:p>","DOI":"10.1093\/eurpub\/ckaf064","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T18:00:16Z","timestamp":1751652016000},"page":"835-843","source":"Crossref","is-referenced-by-count":0,"title":["Basing healthcare decisions on value: patient-reported outcomes for patients diagnosed with breast cancer in a European cohort"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9747-5816","authenticated-orcid":false,"given":"Ania","family":"Gorostiza","sequence":"first","affiliation":[{"name":"Biosistemak Institute for Health Systems Research, B Accelerator Tower (BAT) , Bilbao, Bizkaia,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Cacicedo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Cruces University Hospital\/Biobizkaia Health Research Institute , Barakaldo, Bizkaia,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itxaso","family":"Alayo","sequence":"additional","affiliation":[{"name":"Biosistemak Institute for Health Systems Research, B Accelerator Tower (BAT) , Bilbao, Bizkaia,","place":["Spain"]},{"name":"Red de Investigaci\u00f3n en Cronicidad, Atenci\u00f3n Primaria y Promoci\u00f3n de la Salud RICAPPS-(RICORS). Instituto de Salud Carlos III (ISCIII) , Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andere","family":"Frias","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Cruces University Hospital\/Biobizkaia Health Research Institute , Barakaldo, Bizkaia,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Cobos Baena","sequence":"additional","affiliation":[{"name":"Osakidetza Basque Health Service, Ezkerraldea Enkarterri Cruces Integrated Health Organisation, Mammary Pathology Service , Barakaldo, Bizkaia,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e9s","family":"Gallego Cami\u00f1a","sequence":"additional","affiliation":[{"name":"Innovation and Quality Deputy Direction, Osakidetza Basque Health Service, Ezkerraldea Enkarterri Cruces Integrated Health Organisation , Barakaldo, Bizkaia,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"\u00c1lvarez L\u00f3pez","sequence":"additional","affiliation":[{"name":"Osakidetza Basque Health Service, Donostialdea Integrated Health Organisation, Medical Oncology , Donostia, Gipuzkoa,","place":["Spain"]},{"name":"Biogipuzkoa, Begiristain Doktorea Pasealekua , Donostia, Gipuzkoa,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Fern\u00e1ndez Calleja","sequence":"additional","affiliation":[{"name":"Osakidetza Basque Health Service, Donostialdea Integrated Health Organisation, Mammary Pathology Service, Begiristain Doktorea Pasealekua , Donostia, Gipuzkoa,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Rigabert","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Andaluza Beturia para la Investigaci\u00f3n en Salud (FABIS) , Huelva,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Victoria","family":"Alonso Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Andaluza Beturia para la Investigaci\u00f3n en Salud (FABIS) , Huelva,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Varela Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre , Madrid,","place":["Spain"]},{"name":"Instituto de investigaci\u00f3n biom\u00e9dica del Hospital Universitario 12 de Octubre (I+12) , Madrid,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Danesi","sequence":"additional","affiliation":[{"name":"Outcome Research, Healthcare Administration, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , Meldola,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Roncadori","sequence":"additional","affiliation":[{"name":"Outcome Research, Healthcare Administration, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d , Meldola,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5196-5908","authenticated-orcid":false,"given":"Mario","family":"Campone","sequence":"additional","affiliation":[{"name":"Institut de Canc\u00e9rologie de l\u2019Ouest Angers-Nantes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ane","family":"Fullaondo","sequence":"additional","affiliation":[{"name":"Biosistemak Institute for Health Systems Research, B Accelerator Tower (BAT) , Bilbao, Bizkaia,","place":["Spain"]},{"name":"Red de Investigaci\u00f3n en Cronicidad, Atenci\u00f3n Primaria y Promoci\u00f3n de la Salud RICAPPS-(RICORS). 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