{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:48:32Z","timestamp":1781106512177,"version":"3.54.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010653","name":"Masaryk University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dental and periodontal infections can lead to serious systemic complications through bacterial dissemination. While global awareness of these risks is increasing, data on the incidence and outcomes of such complications remain limited. This study aims to quantify the incidence of serious extraoral infectious complications associated with dental infectious foci, using dental procedures as markers of active oral infection, in the Czech Republic between 2010 and 2022. A retrospective analysis was conducted using data from the National Register of Reimbursed Health Services. Patients who underwent invasive dental procedures indicating active dental\/periodontal infection and were hospitalized for severe infectious conditions within 7 days were identified. This temporal criterion captured both cases where dental procedures preceded systemic spread and cases where dental foci were identified during workup for serious infections. Descriptive statistics and linear regression analysed incidence rates and temporal trends. Among 15\u00a0098\u00a0093 dental procedures over 13\u2009years, annual hospitalizations for associated infectious complications ranged from 855 to 1252 cases. Overall incidence was 12.82 per 100\u00a0000 population annually. Oral region complications (cellulitis, abscesses, osteomyelitis) were most common (9.48 per 100\u00a0000), followed by systemic complications (sepsis and endocarditis) (2.89 per 100\u00a0000). Significant increasing trends were observed for jaw periostitis (P\u2009=\u2009.006), endocarditis (P\u2009&amp;lt;\u2009.001), and central nervous system abscesses (P\u2009=\u2009.027), while acute sinusitis declined (P\u2009&amp;lt;\u2009.001). This population-based analysis reveals a substantial incidence of serious infectious complications associated with dental infectious foci, with concerning increasing trends in potentially life-threatening conditions. These findings emphasize the importance of preventive dental care and early intervention strategies.<\/jats:p>","DOI":"10.1093\/eurpub\/ckaf175","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T11:56:40Z","timestamp":1757505400000},"page":"208-213","source":"Crossref","is-referenced-by-count":2,"title":["The surge in infectious complications of dental and periodontal infections in the Czech Republic between 2010 and 2022"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2946-658X","authenticated-orcid":false,"given":"Mat\u00fa\u0161","family":"Mihal\u010din","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine, Masaryk University , Brno,","place":["Czech Republic"]},{"name":"Department of Infectious Diseases, University Hospital Brno , Brno,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4572-745X","authenticated-orcid":false,"given":"Ale\u0161","family":"Chrdle","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ceske Budejovice Hospital , Ceske Budejovice,","place":["Czech Republic"]},{"name":"Faculty of Health and Social Sciences, University of South Bohemia in Ceske Budejovice , Ceske Budejovice,","place":["Czech Republic"]},{"name":"Tropical and Infectious Disease Unit, Royal Liverpool University Hospital , Liverpool,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2563-7310","authenticated-orcid":false,"given":"Lenka","family":"Fa\u0161anekov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine, Masaryk University , Brno,","place":["Czech Republic"]},{"name":"Department of Infectious Diseases, University Hospital Brno , Brno,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9165-8323","authenticated-orcid":false,"given":"Vojt\u011bch","family":"Pe\u0159ina","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty Hospital Brno and Faculty of Medicine, Masaryk University Brno , Brno,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-9219","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"M\u00e1jek","sequence":"additional","affiliation":[{"name":"Institute of Health Information and Statistics of the Czech Republic , Prague,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1409-1671","authenticated-orcid":false,"given":"Barbora","family":"Mackov\u00e1","sequence":"additional","affiliation":[{"name":"The National Institute of Public Health , Prague,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"2026021717520841900_ckaf175-B1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-0757.2012.00453.x","article-title":"Composition and development of oral bacterial communities","volume":"64","author":"Palmer","year":"2014","journal-title":"Periodontol 2000"},{"key":"2026021717520841900_ckaf175-B2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1128\/CMR.00028-08","article-title":"Microbiology of odontogenic bacteremia: beyond endocarditis","volume":"22","author":"Parahitiyawa","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"2026021717520841900_ckaf175-B3","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1001\/jama.1997.03540460058033","article-title":"Prevention of bacterial endocarditis. Recommendations by the American Heart Association","volume":"277","author":"Dajani","year":"1997","journal-title":"JAMA"},{"key":"2026021717520841900_ckaf175-B4","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/iej.12506","article-title":"Apical periodontitis and cardiovascular diseases: previous findings and ongoing research","volume":"48","author":"Cotti","year":"2015","journal-title":"Int Endod J"},{"key":"2026021717520841900_ckaf175-B5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1600-051X.2006.00924.x","article-title":"Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation","volume":"33","author":"Forner","year":"2006","journal-title":"J Clin Periodontol"},{"key":"2026021717520841900_ckaf175-B6","first-page":"1784","article-title":"Complications of severe odontogenic infections: a review","volume":"11","author":"Neal","year":"2022","journal-title":"Biology (Basel)"},{"key":"2026021717520841900_ckaf175-B7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/0975-5950.183867","article-title":"A review of complications of odontogenic infections","volume":"6","author":"Bali","year":"2015","journal-title":"Natl J Maxillofac Surg"},{"key":"2026021717520841900_ckaf175-B8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.recesp.2021.09.010","article-title":"Incidence and mortality of infective endocarditis caused by oral streptococci in the last three decades at a referral center in Spain","volume":"75","author":"Anguita","year":"2022","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"2026021717520841900_ckaf175-B9","author":"\u00dastav zdravotnick\u00fdch informac\u00ed a statistiky \u010cR. N\u00e1rodn\u00ed registr hrazen\u00fdch zdravotn\u00edch slu\u017eeb [Internet]. Praha: \u00daZIS \u010cR"},{"key":"2026021717520841900_ckaf175-B10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ijcard.2015.04.123","article-title":"Clinical epidemiology in Italian registry of infective endocarditis (RIEI): focus on age, intravascular devices and enterococci","volume":"190","author":"Cecchi","year":"2015","journal-title":"Int J Cardiol"},{"key":"2026021717520841900_ckaf175-B11","author":"\u010cesk\u00fd statistick\u00fd \u00fa\u0159ad. V\u011bkov\u00e1 struktura [dataset]. 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