{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:08:40Z","timestamp":1788815320570,"version":"build-2803163510"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006544","name":"Israeli Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Psychologically Informed Reminder Messages (PIRMs) may promote health-behavior change, but their impact on preventive genetic screening is unclear. Due to low adherence to a screening program, Clalit Health Services initiated an intervention to encourage BRCA1\/2 carrier screening in July 2022. This observational study assesses the effectiveness of the intervention in encouraging screening and its spillover effect on related healthcare utilization, focusing on Ashkenazi Jewish females aged 25\u201350 with no relevant cancer history. Patients were randomly assigned to receive one of five PIRMs. Four PIRMs utilized different psychological strategies, while the fifth served as a control. The effectiveness of the intervention on screening adherence was assessed using a regression discontinuity analysis. A Cox regression assessed the effectiveness of the four PIRMs compared to the control. Spillover effects on healthcare utilization were evaluated using logistic regressions. The intervention showed a positive correlation with increased adherence to screening (\u03b2 = 0.37, 95% CI: 0.01\u20130.72). The \u201cBarrier Remover\u201d PIRM emphasized ease (hazards ratio\u2009=\u20091.09, 95% CI: 1.02\u20131.16), while the \u201cHealth Control\u201d PIRM focused on autonomy (hazards ratio\u2009=\u20091.07, 95% CI: 1.01\u20131.14), both indicating greater effectiveness than the control. The findings suggest a positive short-term spillover effect of the \u201cHealth Control\u201d PIRM on healthcare utilization compared to the control (odds ratio\u2009=\u20091.16, 95% CI: 1.04\u20131.29). PIRMs effectively increased BRCA1\/2 carrier screening adherence, demonstrating a scalable, low-cost intervention to improve preventive healthcare uptake. The effect varied by the psychological strategies, highlighting the potential of tailored behavioral interventions to enhance public health.<\/jats:p>","DOI":"10.1093\/eurpub\/ckag044","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:31:11Z","timestamp":1775086271000},"source":"Crossref","is-referenced-by-count":0,"title":["Psychologically informed reminder messages for promoting\n                    <i>BRCA1\/2<\/i>\n                    carrier screening: evidence from a large-scale population-based study"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4505-8704","authenticated-orcid":false,"given":"Tom","family":"Mushkat","sequence":"first","affiliation":[{"name":"Clalit Research Institute, Innovation Division, Clalit Health Services, Ramat Gan,","place":["Israel"]},{"name":"Department of Psychology, Faculty of Social Sciences, The Hebrew University of Jerusalem , Jerusalem,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1315-6835","authenticated-orcid":false,"given":"Rotem","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Clalit Research Institute, Innovation Division, Clalit Health Services, Ramat Gan,","place":["Israel"]},{"name":"The Ivan and Francesca Berkowitz Family Living Laboratory Collaboration, Harvard Medical School and Clalit Research Institute , Boston, MA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0955-0802","authenticated-orcid":false,"given":"Ofer","family":"Isakov","sequence":"additional","affiliation":[{"name":"Clalit Research Institute, Innovation Division, Clalit Health Services, Ramat Gan,","place":["Israel"]},{"name":"The Ivan and Francesca Berkowitz Family Living Laboratory Collaboration, Harvard Medical School and Clalit Research Institute , Boston, MA,","place":["United States"]},{"name":"Gray Faculty of Medicine and Health Sciences, Tel Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah","family":"Hayek","sequence":"additional","affiliation":[{"name":"Clalit Research Institute, Innovation Division, Clalit Health Services, Ramat Gan,","place":["Israel"]},{"name":"Department of Epidemiology and Preventive Medicine, School of Public Health, Gray Faculty of Medicine and Health Sciences, Tel Aviv, Israel\u00a0"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadassah","family":"Raskas","sequence":"additional","affiliation":[{"name":"Clalit Research Institute, Innovation Division, Clalit Health Services, Ramat 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