{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:08:44Z","timestamp":1788815324124,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:00:00Z","timestamp":1774656000000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Drug shortages are a growing public health issue, unevenly impacting therapeutic classes. Despite variations in drug consumption across populations, the consequences of these shortages on different patient groups remain insufficiently characterized. This study investigated age and sex profiles of patients consuming the therapeutic classes most commonly affected by drug shortages in France. The age and sex risk of shortage exposure were estimated in a nationwide retrospective study of French patients between 2014 and 2023, using data from the French drug shortage notification system and the national health insurance for the entire French population. Over 10 years, 17 505 drug shortage reports were recorded, 60.8% involving cardiovascular, nervous system, and anti-infective agents. Significantly higher mean percentages of consumers for drugs concerned by shortage reports per 1000 were observed in \u226560-year-old patients for 12 of the 14 therapeutic classes, compared to 20\u201359-year-old patients (P\u2009=\u2009.002). Younger population was more significantly concerned by anti-infective agents (11.2 vs 9.2, P\u2009=\u2009.002), respiratory system (1.8 vs 1.5, P\u2009=\u2009.002), and sensory organ (0.7 vs 0.6, P\u2009=\u2009.002) classes. Significantly higher mean percentages of consumers for drugs concerned by shortage reports per 1000 were observed for all Anatomical Therapeutic Chemical 1st level classes in women (P\u2009=\u2009.002), but agents acting on the renin\u2013angiotensin system were higher for men (2.32 vs 2.02; P\u2009=\u2009.002). Our exploratory results suggest that a population-level approach is essential to understand how shortages affect different groups and exacerbate health inequalities.<\/jats:p>","DOI":"10.1093\/eurpub\/ckag045","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T22:39:41Z","timestamp":1774737581000},"source":"Crossref","is-referenced-by-count":0,"title":["Age and sex disparities in drug shortage impacts: a 10-year nationwide study in France"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7408-2761","authenticated-orcid":false,"given":"La\u00ebtitia","family":"Belgod\u00e8re","sequence":"first","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) , Saint Denis,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Leleu","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) , Saint Denis,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trystan","family":"Bacon","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) , Saint Denis,","place":["France"]},{"name":"Coll\u00e8ge universitaire de m\u00e9decine g\u00e9n\u00e9rale, Universit\u00e9 Claude Bernard Lyon1 , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Daynes","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) , Saint Denis,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Decoene","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) , Saint Denis,","place":["France"]},{"name":"P\u00f4le anesth\u00e9sie-r\u00e9animation, Centre hospitalier universitaire de Lille , Lille,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Feugier","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) , Saint Denis,","place":["France"]},{"name":"Universit\u00e9 Claude Bernard Lyon 1 Service de Chirurgie Vasculaire et Endovasculaire (LYVES), , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseline","family":"Mazet","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) , Saint Denis,","place":["France"]},{"name":"Centre hospitalier universitaire de Grenoble-Alpes , Grenoble,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Vial","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) , Saint Denis,","place":["France"]},{"name":"Hospices Civils de Lyon , Lyon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Vignot","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) , Saint Denis,","place":["France"]},{"name":"EA7509 Universit\u00e9 Reims Champagne Ardenne , Reims,","place":["France"]},{"name":"Institut Godinot , Reims,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Benkebil","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) , Saint Denis,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahiba","family":"Oualikene-Gonin","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) , Saint Denis,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Maison","sequence":"additional","affiliation":[{"name":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des Produits de Sant\u00e9 (ANSM) , Saint Denis,","place":["France"]},{"name":"CHI Cr\u00e9teil , Cr\u00e9teil,","place":["France"]},{"name":"EA 7379, Epiderme, Facult\u00e9 de Sant\u00e9, Universit\u00e9 Paris-Est Cr\u00e9teil , Cr\u00e9teil,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"2026090716340168800_ckag045-B1","author":"Eleventh Annual Report on 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years of experience","volume":"11","author":"Belgod\u00e8re","year":"2023","journal-title":"Front Public Health"},{"key":"2026090716340168800_ckag045-B7","year":"2012"},{"key":"2026090716340168800_ckag045-B8","year":"2016"},{"key":"2026090716340168800_ckag045-B9","year":"2021"},{"key":"2026090716340168800_ckag045-B10","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1001\/jama.2024.5296","article-title":"Global production of active pharmaceutical ingredients for US generic drugs experiencing shortages","volume":"331","author":"Socal","year":"2024","journal-title":"JAMA"},{"key":"2026090716340168800_ckag045-B11","author":"Pierce","year":"2023."},{"key":"2026090716340168800_ckag045-B12","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1111\/bcp.15853","article-title":"Drug shortages. 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