{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:02:54Z","timestamp":1789351374513,"version":"build-2803163510"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sigrid Juselius Foundation"},{"name":"Finnish Cancer Foundation"},{"DOI":"10.13039\/501100010600","name":"Tampere University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010600","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellbeing services county of Pirkanmaa"},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>High-risk human papillomavirus (HR-HPV) screening effectively reduces cervical cancer incidence, but limited specificity leads to excessive colposcopy referrals. Extended HR-HPV genotyping improves triage by accounting for genotype-specific oncogenic risks, offering a more precise framework for patient management than traditional pooled testing. This study analysed real-world screening data from a Finnish cohort of 2368 HR-HPV-positive women (Tampere region, 2017\u20132019) with up to 6.5\u2009years of follow-up. Extended genotyping was performed using the Seegene Anyplex\u2122II HPV28 Detection assay. Genotype-specific prevalence and cumulative incidence of histology-confirmed High-grade Squamous Intraepithelial Lesions or worse (HSIL+) were assessed and stratified by reflex cytology. Among 3099 detected HR-HPV genotypes, HPV16 was most prevalent (14.3%) and carried the highest HSIL+ risk (35.7%), followed by HPV33 (24.6%) and HPV18 (20.8%). A clear risk hierarchy emerged: the lowest-risk group (HPV59\/39\/68\/51\/56\/66) had an HSIL+ incidence below 4.2%. Notably, HPV16-positive women with NILM\/ASC-US cytology faced a 23.9% HSIL+ risk, exceeding the 21.1% risk seen in the lowest-risk genotype group even when accompanied by LSIL+ cytology. For those with both NILM\/ASC-US and the lowest-risk genotypes, HSIL+ incidence was only 3.4%. A distinct hierarchy of oncogenic risk exists within this population-based cohort. Incorporating genotype-specific data into national screening algorithms is strongly supported. This allows for immediate colposcopy for high-risk groups (e.g. HPV16 with mild cytology) while justifying extended follow-up for lower-risk types, optimizing clinical resources and reducing unnecessary procedures.<\/jats:p>","DOI":"10.1093\/eurpub\/ckag139","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:54:23Z","timestamp":1784807663000},"source":"Crossref","is-referenced-by-count":0,"title":["Improving cervical screening risk stratification through extended human papillomavirus genotyping and age-specific data"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1855-9431","authenticated-orcid":false,"given":"Aarno","family":"Leino","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology, Tampere University , Tampere,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Numminen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology, Tampere University , Tampere,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Fonagy","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Fimlab Laboratories , Tampere,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna","family":"Paloniemi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Fimlab Laboratories , Tampere,","place":["Finland"]},{"name":"Faculty of Medicine and Health Technology, Tampere University , Tampere,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapio","family":"Seiskari","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Fimlab Laboratories , Tampere,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Kholov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fimlab Laboratories , Tampere,","place":["Finland"]},{"name":"Department of Pathology, Faculty of Medicine and Health Technology, Tampere University , Tampere,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Kares","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fimlab Laboratories , Tampere,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-363X","authenticated-orcid":false,"given":"Karolina","family":"Louvanto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology, Tampere University , Tampere,","place":["Finland"]},{"name":"Department of Obstetrics and Gynecology, Tampere University Hospital , Tampere,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"2026091321115391100_ckag139-B1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ygyno.2014.11.076","article-title":"Primary cervical cancer screening with human papillomavirus: end of study results from the ATHENA study using HPV as the first-line screening test","volume":"136","author":"Wright","year":"2015","journal-title":"Gynecol Oncol"},{"key":"2026091321115391100_ckag139-B2","doi-asserted-by":"publisher","first-page":"F88","DOI":"10.1016\/j.vaccine.2012.06.095","article-title":"Evidence regarding human papillomavirus testing in secondary prevention of cervical 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