{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:54:55Z","timestamp":1790373295911,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Lyme borreliosis (LB) is the most frequently reported tick-borne infection in Europe and North America. The aim of this study was to estimate the cost-of-illness of LB in the Netherlands. Methods: We used available incidence estimates from 2010 for tick bite consultations and three symptomatic LB outcomes: erythema migrans (EM), disseminated LB and Lyme-related persisting symptoms. The cost was estimated using these incidences and the average cost per patient as derived from a patient questionnaire. We estimated the cost from a societal perspective, including healthcare cost, patient cost and production loss, using the friction cost method and a 4% annual discount rate. Results: Tick bites and LB in 2010 led to a societal cost of \u20ac19.3 million (95% CI 15.6\u201323.4; 16.6 million population) for the Netherlands. Healthcare cost and production loss each constituted 48% of the total cost (\u20ac9.3 and \u20ac9.2 million\/year), and patient cost 4% (\u20ac0.8 million\/year). Of the total cost, 37% was related to disseminated LB, followed by 27% for persisting symptoms, 22% for tick bites and 14% for EM. Per outcome, for an individual case the mean cost of disseminated LB and Lyme-related persisting symptoms was both around \u20ac5700; for EM and GP consultations for tick bites this was \u20ac122 and \u20ac53. As an alternative to the friction cost method, the human capital method resulted in a total cost of \u20ac23.5 million\/year. Conclusion: LB leads to a substantial societal cost. Further research should therefore focus on additional preventive interventions.<\/jats:p>","DOI":"10.1093\/eurpub\/ckw269","type":"journal-article","created":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T12:06:08Z","timestamp":1483445168000},"page":"538-547","source":"Crossref","is-referenced-by-count":43,"title":["The cost of Lyme borreliosis"],"prefix":"10.1093","volume":"27","author":[{"given":"Cees. C.","family":"van den Wijngaard","sequence":"first","affiliation":[{"name":"National Institute of Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnetha","family":"Hofhuis","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Wong","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment (RIVM), Centre for Nutrition, Prevention and Health Services, Bilthoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margriet G.","family":"Harms","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Ardine","family":"de Wit","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment (RIVM), Centre for Nutrition, Prevention and Health Services, Bilthoven, The Netherlands"},{"name":"Julius Centre for Health Sciences and Primary Care, University Medical Hospital Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Lugn\u00e9r","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita W. M.","family":"Suijkerbuijk","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jos\u00e9e J.","family":"Mangen","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands"},{"name":"Julius Centre for Health Sciences and Primary Care, University Medical Hospital Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfrid","family":"van Pelt","sequence":"additional","affiliation":[{"name":"National Institute of Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"2019071816094820100_ckw269-B1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1469-0691.2010.03175.x","article-title":"Lyme borreliosis: clinical case definitions for diagnosis and management in Europe","volume":"17","author":"Stanek","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"2019071816094820100_ckw269-B2","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/508667","article-title":"The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America","volume":"43","author":"Wormser","year":"2006","journal-title":"Clin Infect Dis"},{"key":"2019071816094820100_ckw269-B3","doi-asserted-by":"crossref","first-page":"697","DOI":"10.7326\/0003-4819-138-9-200305060-00005","article-title":"Duration of antibiotic therapy for early Lyme disease. 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