{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:02:18Z","timestamp":1740178938750,"version":"3.37.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["NSF DEB-1750553"],"award-info":[{"award-number":["NSF DEB-1750553"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Biparental sex is widespread in nature, yet costly relative to uniparental reproduction. It is generally unclear why self-fertilizing or asexual lineages do not readily invade outcrossing populations. The Red Queen hypothesis predicts that coevolving parasites can prevent self-fertilizing or asexual lineages from invading outcrossing host populations. However, only highly virulent parasites are predicted to maintain outcrossing, which may limit the general applicability of the Red Queen hypothesis. Here, we tested whether the ability of coevolving parasites to prevent invasion of self-fertilization within outcrossing host populations was dependent on parasite virulence. We introduced wild-type Caenorhabditis elegans hermaphrodites, capable of both self-fertilization and outcrossing, into C. elegans populations fixed for a mutant allele conferring obligate outcrossing. Replicate C. elegans populations were exposed for 24 host generations to one of four strains of Serratia marcescens parasites that varied in virulence, under three treatments: a heat-killed (control, noninfectious) parasite treatment, a fixed-genotype (nonevolving) parasite treatment, and a copassaged (potentially coevolving) parasite treatment. As predicted, self-fertilization invaded C. elegans host populations in the control and fixed-parasite treatments, regardless of parasite virulence. In the copassaged treatment, selfing invaded host populations coevolving with low- to mid-virulence strains, but remained rare in hosts coevolving with highly virulent bacterial strains. Therefore, we found that only highly virulent coevolving parasites can impede the invasion of selfing.<\/jats:p>","DOI":"10.1093\/evlett\/qrad036","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T15:26:12Z","timestamp":1693927572000},"page":"371-378","source":"Crossref","is-referenced-by-count":3,"title":["High parasite virulence necessary for the maintenance of host outcrossing via parasite-mediated selection"],"prefix":"10.1093","volume":"7","author":[{"given":"Samuel P","family":"Slowinski","sequence":"first","affiliation":[{"name":"Department of Biology, University of Maryland , College Park, MD , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JaeHoon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Biology, Emory University , Atlanta GA , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"McKenna J","family":"Penley","sequence":"additional","affiliation":[{"name":"Department of Biology, Emory University , Atlanta GA , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura W","family":"Alexander","sequence":"additional","affiliation":[{"name":"Department of Integrative Biology, University of California , Berkeley, CA , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arielle B","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Biology, Emory University , Atlanta GA , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sathvik R","family":"Namburar","sequence":"additional","affiliation":[{"name":"Department of Biology, Emory University , Atlanta GA , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levi T","family":"Morran","sequence":"additional","affiliation":[{"name":"Department of Biology, Emory University , Atlanta GA , United 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A pluralist approach revisited","volume":"32","author":"Neiman","year":"2017","journal-title":"Trends in Ecology & Evolution"},{"key":"2023120211300488000_CIT0039","first-page":"1018","article-title":"Species interactions and the evolution of sex","volume-title":"Science","author":"Otto","year":"2004"},{"key":"2023120211300488000_CIT0040","first-page":"e0181913","article-title":"Evolution of Caenorhabditis elegans host defense under selection by the bacterial parasite Serratia marcescens","volume-title":"PLoS One","author":"Penley","year":"2017"},{"key":"2023120211300488000_CIT0041","first-page":"724","article-title":"Host mating system and coevolutionary dynamics shape the evolution of parasite avoidance in Caenorhabditis elegans host populations","volume-title":"Parasitology","author":"Penley","year":"2018"},{"key":"2023120211300488000_CIT0042","first-page":"377","article-title":"Multiparasite communities in animals and humans: Frequency, structure and pathogenic significance","volume-title":"International Journal for Parasitology","author":"Petney","year":"1998"},{"key":"2023120211300488000_CIT0043","first-page":"2295","article-title":"Detection and avoidance of a natural product from the pathogenic bacterium Serratia marcescens by Caenorhabditis elegans","volume-title":"Proceedings of the National Academy of Sciences of the United States of America","author":"Pradel","year":"2007"},{"key":"2023120211300488000_CIT0044","first-page":"43","article-title":"Fog-2, a germ-line-specific sex determination gene required for hermaphrodite spermatogenesis in Caenorhabditis elegans","volume-title":"Genetics","author":"Schedl","year":"1988"},{"key":"2023120211300488000_CIT0045","first-page":"2632","article-title":"Coevolutionary interactions with parasites constrain the spread of self-fertilization into outcrossing host populations","volume-title":"Evolution","author":"Slowinski","year":"2016"},{"key":"2023120211300488000_CIT0046","first-page":"975","article-title":"Selection and maintenance of androdioecy in Caenorhabditis elegans","volume-title":"Genetics","author":"Stewart","year":"2002"},{"key":"2023120211300488000_CIT0047","first-page":"212","article-title":"Prevalence, host specificity and impact on host fecundity of microparasites and epibionts in three sympatric Daphnia species","volume-title":"Journal of Animal Ecology","author":"Stirnadel","year":"1997"},{"key":"2023120211300488000_CIT0048","first-page":"484","article-title":"The geographic mosaic of sex and infection in lake populations of a New Zealand snail at multiple spatial scales","volume-title":"American Naturalist","author":"Vergara","year":"2013"},{"key":"2023120211300488000_CIT0049","first-page":"304","article-title":"Fertilization and sperm competition in the nematode Caenorhabditis elegans","volume-title":"Developmental Biology","author":"Ward","year":"1979"},{"key":"2023120211300488000_CIT0050","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1420-9101.1999.00119.x","article-title":"A pluralist approach to sex and recombination","volume":"12","author":"West","year":"1999","journal-title":"Journal of Evolutionary Biology"},{"volume-title":"Sex and evolution","year":"1975","author":"Williams","key":"2023120211300488000_CIT0051"}],"container-title":["Evolution Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/evlett\/article-pdf\/7\/6\/371\/53974720\/qrad036.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/evlett\/article-pdf\/7\/6\/371\/53974720\/qrad036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T11:30:37Z","timestamp":1701516637000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/evlett\/article\/7\/6\/371\/7260562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,5]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,9,5]]},"published-print":{"date-parts":[[2023,12,2]]}},"URL":"https:\/\/doi.org\/10.1093\/evlett\/qrad036","relation":{},"ISSN":["2056-3744"],"issn-type":[{"type":"electronic","value":"2056-3744"}],"subject":[],"published-other":{"date-parts":[[2023,12,1]]},"published":{"date-parts":[[2023,9,5]]}}}