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Here, we focus on this system in nature, where natural selection can counter CN\/gene product escalation. Our model is house mouse subspecies hybridizing in Europe. In some regions, Y chromosomes of the Eastern subspecies have introgressed onto Western genomic backgrounds, accompanied by sex ratio distortion in favor of males, consistent with the inbred lines suggested mechanism: Overabundance of SLY protein expressed by invading Y chromosomes. We take Slx as representative of the X side of this arms race and measure Slx|Sly CN and expression across an \u201cInvasion\u201d transect where Ys introgress and a \u201cControl\u201d transect with negligible introgression. Since we found similar Slx|Sly ratios in both transects, SLY overabundance is unlikely to explain the introgression. However, Slx CN is relatively low in the introgression area, suggesting that Slx is less able to combat Sly effects here. Furthermore, deterministic changes in Slx;Sly expression proportions versus CN proportions suggest standing variation for trans regulation of Slx|Sly is being co-opted in nature where their arms race reduces population fitness.<\/jats:p>","DOI":"10.1093\/evolut\/qpad051","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T05:25:55Z","timestamp":1679635555000},"page":"1330-1340","source":"Crossref","is-referenced-by-count":9,"title":["A gene copy number arms race in action: X,Y-chromosome transmission distortion across a species barrier"],"prefix":"10.1093","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7144-9919","authenticated-orcid":false,"given":"Stuart J E","family":"Baird","sequence":"first","affiliation":[{"name":"Institute of Vertebrate Biology, Czech Academy of Sciences, Research Facility in Studenec , Brno , Czech 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