{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:10:13Z","timestamp":1788779413384,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_192786"],"award-info":[{"award-number":["310030_192786"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["CRSII5_198543"],"award-info":[{"award-number":["CRSII5_198543"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Multidisciplinary Center for Infectious Diseases","award":["SA_11"],"award-info":[{"award-number":["SA_11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There is currently no theory which mechanistically links parasite virulence and host senescence. One driver of senescence is energy metabolism. We expect parasites to contribute to senescence because infection increases energy allocation to the immune system, which elevates oxidative stress and damages macromolecules. Additionally, parasites deplete their host\u2019s energy, which can increase the host\u2019s rate of mortality. While these within-host processes can contribute to mortality, they also determine the risk of parasite infection through epidemiological dynamics. To understand quantitatively the impact of these interactions on infection dynamics and on the evolution of within-host parasite growth (virulence), we developed a multiscale model that describes within-host and among-host dynamics. We found that infection prevalence is maximized at intermediate levels of resource acquisition only when energy depletion contributes to senescence. Furthermore, for a single resource level, there are 2 evolutionary equilibria for the parasite growth rate. This is the first time the molecular mechanisms determining senescence have been considered in the context of parasite infection, allowing us to link virulence and senescence. Our mechanistic framework provides an alternative to the virulence\u2013transmission trade-off and reconciles conflicting empirical findings on the impact of resources on epidemiological dynamics and virulence.<\/jats:p>","DOI":"10.1093\/evolut\/qpag084","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:35:58Z","timestamp":1780400158000},"page":"1905-1916","source":"Crossref","is-referenced-by-count":0,"title":["Parasitic infection and resource acquisition shape senescence through oxidative stress and energy depletion"],"prefix":"10.1093","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5755-2867","authenticated-orcid":false,"given":"Jonathan I D","family":"Hamley","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern , Bern ,","place":["Switzerland"]},{"name":"Multidisciplinary Center for Infectious Diseases, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sanchez-Taltavull","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob C","family":"Koella","sequence":"additional","affiliation":[{"name":"Institute of Biology, University of Neuch\u00e2tel , Neuch\u00e2tel ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Stroka","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern , Bern ,","place":["Switzerland"]},{"name":"Multidisciplinary Center for Infectious Diseases, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"issue":"9","key":"2026090706222726400_bib1","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1890\/13-2007.1","article-title":"No uniform associations between parasite prevalence and environmental nutrients","volume":"95","author":"Aalto","year":"2014","journal-title":"Ecology"},{"issue":"6","key":"2026090706222726400_bib2","doi-asserted-by":"publisher","first-page":"E155","DOI":"10.1086\/430053","article-title":"Emergence of a convex trade-off between transmission and virulence","volume":"165","author":"Alizon","year":"2005","journal-title":"The American Naturalist"},{"issue":"(1)","key":"2026090706222726400_bib3","doi-asserted-by":"publisher","first-page":"219","DOI":"10.2307\/3933","article-title":"Regulation and Stability of Host-Parasite Population Interactions: I. 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