{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:00:38Z","timestamp":1789646438728,"version":"4.0.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>As long-term use of benzodiazepines increases, adverse effects also become more frequent, especially in elderly adults. Due the potential of causing dependence, poor patient adherence and a lack of awareness of side effects, deprescription is challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to identify what are the effective approaches to motivate and promote deprescription of benzodiazepines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used MeSH terms to search in five databases that were MEDLINE, Cochrane CENTRAL, LILACS, SCIELO and Science Direct. Then, we selected articles accordingly to inclusion and exclusion criteria. Risk of bias assessment for randomized controlled trials and prospective interventional studies was made using RoB 2.0 and ROBINS-I tools, respectively. For cohort studies, we used the clarity group by McMaster University tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Database search retrieved 412 results, and 11 studies were selected for analysis. Interventions focusing on patient education to improve community awareness about deprescription presented better discontinuation rates and more potential on motivating discussions about deprescribing with physicians. Interventions based on counselling by different health professionals were not well evaluated as they presented four of six studies as high, serious or critical risk of bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the comparison of different strategies was impaired by the high risk of bias in some studies, patient education focused interventions presented good results. Future studies should consider doing a follow-up of 6 months or longer with evaluation of withdrawal symptoms and sleep patterns, inclusion of young adults on the sample and some form of cognitive evaluation that might influence the results of the intervention.<\/jats:p><\/jats:sec>","DOI":"10.1093\/fampra\/cmab017","type":"journal-article","created":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T14:36:44Z","timestamp":1613486204000},"page":"684-693","source":"Crossref","is-referenced-by-count":25,"title":["Benzodiazepine deprescription strategies in chronic users: a systematic review"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6334-3794","authenticated-orcid":false,"given":"P\u00e9ricles Ricardo de Souza","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Public Health School of Florian\u00f3polis, Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0996-6242","authenticated-orcid":false,"given":"Aline Daiane","family":"Schlindwein","sequence":"additional","affiliation":[{"name":"Science and Technology Division, Directorate of Permanent Health Education, State Secretariat of Health of Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"issue":"1","key":"2021092506421061900_CIT0001","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1590\/1980-5497201700010005","article-title":"Uso de psicof\u00e1rmacos entre idosos residentes em comunidade: preval\u00eancia e fatores associados","volume":"20","author":"Abi-Ackel","year":"2017","journal-title":"Rev Bras Epidemiol"},{"issue":"1","key":"2021092506421061900_CIT0002","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/0004867412466595","article-title":"Trends in the utilisation of psychotropic medications in Australia from 2000 to 2011","volume":"47","author":"Stephenson","year":"2013","journal-title":"Aust N Z J Psychiatry"},{"issue":"5","key":"2021092506421061900_CIT0003","first-page":"339","article-title":"Deprescribing benzodiazepine receptor agonists: Evidence-based clinical practice guideline","volume":"64","author":"Pottie","year":"2018","journal-title":"Can Fam Physician"},{"issue":"1","key":"2021092506421061900_CIT0004","doi-asserted-by":"crossref","first-page":"E52","DOI":"10.9778\/cmajo.20160056","article-title":"Long-term sedative use among community-dwelling adults: a population-based analysis","volume":"5","author":"Weymann","year":"2017","journal-title":"CMAJ Open"},{"issue":"1","key":"2021092506421061900_CIT0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2165\/0023210-200923010-00002","article-title":"Withdrawing benzodiazepines in primary care","volume":"23","author":"Lader","year":"2009","journal-title":"CNS Drugs"},{"issue":"15","key":"2021092506421061900_CIT0006","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1056\/NEJMcp1412740","article-title":"Clinical practice. 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