{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:37:28Z","timestamp":1772138248306,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Upper airway cough syndrome (UACS) is generally considered a common cause of chronic cough but remains poorly recognised in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess whether UACS was a common cause of chronic cough in Japan, as is true in other countries. Interview and examination items were evaluated for their potential use in UACS diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients with chronic cough were preliminarily diagnosed with bronchial asthma, UACS, gastroesophageal reflux disease, or postinfectious prolonged cough, based on interviews and examinations. Treatment centred on nasal steroids was administered to the UACS group and standard treatment to the other groups. The observation period lasted 4 weeks. The subjective cough score at first diagnosis was set at 10, and the final diagnosis was made based on the treatment administered at the time the cough score had decreased to \u22642. The associations between the presence or absence of UACS and interview and examination items were statistically evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 230 patients with chronic cough, 146 were diagnosed with UACS-only. Multivariate logistic regression revealed that the assessment items \u2018awareness of mucus accumulating in the back of the throat\u2019, \u2018presence of abnormal echography findings\u2019, \u2018absence of associated coughing when exercising\u2019 and \u2018presence of coughing persisting after onset\u2019 were significantly correlated with the presence or absence of UACS (p &amp;lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UACS may be the most common cause of chronic cough in Japan and may be effectively treated with nasal corticosteroids. Diagnosing UACS might be possible by selecting appropriate interview and examination items.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/fampra\/cmab046","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T15:43:36Z","timestamp":1617810216000},"source":"Crossref","is-referenced-by-count":1,"title":["Upper airway cough syndrome may be the main cause of chronic cough in Japan: a cohort study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1877-1009","authenticated-orcid":false,"given":"Kimihiko","family":"Yasuda","sequence":"first","affiliation":[{"name":"Yasuda Clinic, Internal Medicine, 2-2-20-2F, Takasago, Urawa-ku, Saitama-shi, Saitama, 330-0063, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"2021070818533499300_CIT0001","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1378\/chest.129.1_suppl.1S","article-title":"Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines","volume":"129","author":"Irwin","year":"2006","journal-title":"Chest"},{"key":"2021070818533499300_CIT0002","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thx.2006.065144","article-title":"Recommendations for the management of cough in adults","volume":"61","author":"Morice","year":"2006","journal-title":"Thorax"},{"key":"2021070818533499300_CIT0003","first-page":"S135","article-title":"The Japanese Respiratory Society guidelines for management of cough","volume":"11","author":"Committee for the Japanese Respiratory Society Guidelines for Management of Cough","year":"2006","journal-title":"Respirology"},{"issue":"1","key":"2021070818533499300_CIT0004","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.chest.2017.10.016","article-title":"Classification of cough as a symptom in adults and management algorithms: CHEST guideline and expert panel report","volume":"153","author":"Irwin","year":"2018","journal-title":"Chest"},{"key":"2021070818533499300_CIT0005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1378\/chest.114.2_Supplement.133S","article-title":"Managing cough as a defense mechanism and as a symptom. 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