{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:03:38Z","timestamp":1794002618935,"version":"4.8.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"departmental resources"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In France, general practitioners (GPs) prescribe benzodiazepines and Z-drugs (BZD\/ZDs) widely, and especially to older adults. Several characteristics of patients and\/or GPs linked to BZD\/ZD overprescription have been described in the general population but not among older patients in primary care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To estimate the proportion of GP consultations by patients aged 65 and over that resulted in a BZD\/ZD prescription, and determine whether any GP-related factors predicted BZD\/ZD overprescription in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed sociodemographic and practice-related GP characteristics, and aggregated data on consultations recorded prospectively by 117 GPs in a database between 2000 and 2010. Next, we used logistic regression models to look for factors potentially associated with BZD\/ZD overprescription (defined as an above-median prescription rate).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The GPs\u2019 mean age at inclusion was 47.4 (7.1), and 87.9% were male. During the study period, the median (95% confidence interval) proportion of consultations with patients aged 65 and over resulting in a BZD\/ZD prescription was 21.8% (18.1\u201326.1) (range per GP: 5\u201334.1%). In a multivariable analysis, a greater number of chronic disease (OR [95% CI] = 2.10 [1.22\u20133.64]), a greater number of drugs prescribed per consultation (5.29 [2.72\u201310.28]), and shorter study participation were independently associated with BZD\/ZD overprescription.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BZD\/ZD overprescription was associated with a greater chronic disease burden and the number of drugs prescribed per consultation but not with any sociodemographic or practice-related GP characteristics. Targeted actions are needed to help GPs limit their prescription of BZD\/ZDs to older patients with multiple comorbidities and polypharmacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/fampra\/cmac114","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T13:05:39Z","timestamp":1664543139000},"page":"419-425","source":"Crossref","is-referenced-by-count":2,"title":["Prescription of benzodiazepines and Z-drugs among older patients in primary care: a French, national, cohort study"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6730-4397","authenticated-orcid":false,"given":"Jonathan","family":"Yana","sequence":"first","affiliation":[{"name":"Univ Paris-Est Creteil, School of Medicine, Primary Care Department , F-94010 Creteil , France"},{"name":"Maison de Sant\u00e9 pluri-professionnelle Universitaire de St-Maur des Foss\u00e9s , F-94100 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Moscova","sequence":"additional","affiliation":[{"name":"Univ Paris-Est Creteil, School of Medicine, Primary Care Department , F-94010 Creteil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Le Breton","sequence":"additional","affiliation":[{"name":"Univ Paris-Est Creteil, School of Medicine, Primary Care Department , F-94010 Creteil , France"},{"name":"Univ Paris Est Creteil, INSERM, IMRB , F-94010 Creteil , France"},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de M\u00e9decine G\u00e9n\u00e9rale , Issy Les Moulineaux, F-92130 , France"},{"name":"Centre de sant\u00e9 universitaire Salvador Allende , F-93120 La Courneuve , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Boutin","sequence":"additional","affiliation":[{"name":"Univ Paris Est Creteil, INSERM, IMRB , F-94010 Creteil , France"},{"name":"APHP, Hopital Henri-Mondor, Unit\u00e9 de Recherche Clinique (URC Mondor) , F-94000 Creteil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiphaine","family":"Siess","sequence":"additional","affiliation":[{"name":"Univ Paris-Est Creteil, School of Medicine, Primary Care Department , F-94010 Creteil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Clerc","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de M\u00e9decine G\u00e9n\u00e9rale , Issy Les Moulineaux, F-92130 , France"},{"name":"Primary Care Department, Universit\u00e9 de Versailles, School of Medicine , F-78000 Versailles , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Bastuji-Garin","sequence":"additional","affiliation":[{"name":"Univ Paris Est Creteil, INSERM, IMRB , F-94010 Creteil , France"},{"name":"Department of Public Health, APHP, Hopital Henri-Mondor , F-94000 Creteil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Ferrat","sequence":"additional","affiliation":[{"name":"Univ Paris-Est Creteil, School of Medicine, Primary Care Department , F-94010 Creteil , France"},{"name":"Maison de Sant\u00e9 pluri-professionnelle Universitaire de St-Maur des Foss\u00e9s , F-94100 , France"},{"name":"Univ Paris Est Creteil, INSERM, IMRB , F-94010 Creteil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,29]]},"reference":[{"issue":"12","key":"2024081423370397000_CIT0001","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00228-011-1077-5","article-title":"Potentially inappropriate drug prescription in the elderly in France: A population-based study from the French National Insurance Healthcare system","volume":"67","author":"Bongue","year":"2011","journal-title":"Eur J Clin Pharmacol"},{"issue":"1\u20132","key":"2024081423370397000_CIT0002","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jad.2008.01.011","article-title":"Clinical factors influencing the prescription of antidepressants and benzodiazepines:. 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