{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T18:20:22Z","timestamp":1772907622231,"version":"3.50.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"5-6","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Regional Cancer Centre Stockholm Gotland, Sweden"},{"name":"Einar Belv\u00e9n foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Early detection of colorectal cancer (CRC) is crucial for survival. Primary care, the first point of contact in most cases, needs supportive risk assessment tools. We aimed to replicate the Swedish Colorectal Cancer Risk Assessment Tool (SCCRAT) for non-metastatic CRC in primary care and examine if risk factor patterns depend on sex and age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>2,920 adults diagnosed with non-metastatic CRC during the years 2015\u20132019 after having visited a general practitioner the year before the diagnosis were selected from the Swedish Cancer Register and matched with 11,628 controls, using the same inclusion criteria except for the CRC diagnosis. Diagnostic codes from primary care consultations were collected from a regional health care database. Positive predictive values (PPVs) were estimated for the same 5 symptoms and combinations thereof as in the baseline study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The results for patients aged \u226550 years old in the present study were consistent with the results of the SCCRAT study. All symptoms and combinations thereof with a PPV &amp;gt;5% in the present study had a PPV &amp;gt;5% in the baseline study. The combination of bleeding with abdominal pain (PPV 9.9%) and bleeding with change in bowel habit (PPV 7.8%) were the highest observed PPVs in both studies. Similar risk patterns were seen for all ages and when men and women were studied separately.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This external validation of the SCCRAT for non-metastatic CRC in primary care replicated the baseline study successfully and identified patients at high risk for CRC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/fampra\/cmac147","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T03:53:46Z","timestamp":1673150026000},"page":"844-851","source":"Crossref","is-referenced-by-count":2,"title":["Validation of a diagnostic prediction tool for colorectal cancer: a case\u2013control replication study"],"prefix":"10.1093","volume":"40","author":[{"given":"Elinor","family":"Nemlander","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet , Solna , Sweden"},{"name":"Academic Primary Health Care Centre , Region Stockholm, Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Rosenblad","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet , Solna , Sweden"},{"name":"Regional Cancer Centre Stockholm-Gotland , Region Stockholm, Stockholm , Sweden"},{"name":"Department of Medical Sciences, Division of Clinical Diabetology and Metabolism, Uppsala University , Uppsala , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliya","family":"Abedi","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet , Solna , Sweden"},{"name":"Academic Primary Health Care Centre , Region Stockholm, Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Hasselstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet , Solna , Sweden"},{"name":"Academic Primary Health Care Centre , Region Stockholm, Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Sj\u00f6vall","sequence":"additional","affiliation":[{"name":"Division of Coloproctology, Department of Pelvic Cancer, Karolinska University Hospital, Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6113-0472","authenticated-orcid":false,"given":"Axel C","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Division of Family 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